With cutting-edge and clinically relevant information, MECHANICAL VENTILATION, 2nd Edition takes a practical, clinical approach to the principles and practice of mechanical ventilation. This informative resource explains mechanical ventilation decisions and procedures in real-world terms so information is easy to understand and apply. This thoroughly updated edition includes one new chapter, four completely updated chapters, and a wealth of new user-friendly features. Detailed, clinically focused coverage of the application of mechanical ventilation to the most common respiratory diseases, provides practical answers to real life problems. UNIQUE! Sections of chapters on Special Techniques and Future Therapies include information on the newest techniques for treating patients in respiratory distress. A separate appendix of case studies helps you apply what you've learned to realistic situations. Well-known and respected authors, Neil MacIntyre and Rich Branson, share their vast expertise and accurate, cutting-edge information. Chapter Objectives, Key Point Summaries, and Assessment Questions reinforce basic concepts from each chapter. New chapter on Unique Patient Populations highlights the mechanical ventilation issues of traumatic brain injury, neuromuscular disease, lung transplantation, burn injury, and perioperative patient populations. Expanded glossary includes relevant terminology and key terms to help you easily find unfamiliar terminology.

This issue of Clinics in Chest Medicine, guest-edited by Dr. M. Patricia Rivera, is the first of two issues focused on Lung Cancer. Topics discussed in this issue include but are not limited to: Lung Cancer in the 21st Century; Epidemiology, Etiology, and Prevention; Lung Cancer in Women: A Modern Epidemic; Primary Prevention of Lung Cancer: Tobacco Treatment; The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment; Pathology of Lung Cancer; Lung Cancer Screening: Patient Selection and Implementation; The Approach to the Subsolid Nodule; Bronchoscopic Diagnostic Procedures Available to the Pulmonologist; Bronchoscopic Therapeutic Procedures Available to the Pulmonologist; and Biomarkers in Lung Cancer.

This issue of Clinics in Chest Medicine, edited by Dr. Charles L. Daley and Dr. David Lewinsohn, focuses on Tuberculosis. Topics include: Epidemiology of Tuberculosis (TB) in the United States; Immunology of Tuberculosis; Tuberculosis and Biologics; Laboratory Diagnosis of Tuberculosis; Supranational Tuberculosis Reference Laboratories (a global approach); Treatment of Drug Susceptible Tuberculosis; Treatment of Drug-Resistant Tuberculosis; New Drugs for the Treatment of Tuberculosis; Diagnosis of Latent Tuberculosis: the Role of Interferon Gamma Release; Treatment of Latent Tuberculosis; Management of Children with Tuberculosis; Tuberculosis and HIV; The Future of Vaccines for Tuberculosis; and Preventing Transmission of M. Tuberculosis.

This issue of Clinics in Chest Medicine, edited by Dr. Denis O'Donnell and Dr. Alberto Neder, focuses on Clinical Respiratory Physiology. Articles include: The Pathophysiology of Obstructive Sleep Apnea; The Physiology of Mechanical Ventilation; Exercise Pathophysiology in Congestive Heart Failure; Control of Breathing; Breathing at Extremes; Exercise Pathophysiology in Interstitial Lung Disease; Importance of Physiology in Clinical Decision-Making in the ICU; Pulmonary Hypertension and Exercise; Physiologic Effects of Oxygen Supplementation During Exercise in COPD; Benefits and Pitfalls of DLCO measurements in Clinical Practice; Cardio-pulmonary Interactions in COPD-CHF; Exercise Physiology in COPD; Dyspnea of Unknown Origin: The Role of Exercise Testing; Assessment of Ventilatory Limitation During Exercise; Respiratory Muscle Assessment in Clinical Practice; Exertional Periodic Breathing in Heart Failure; and Strategies to Increase Physical Activity in Chronic Respiratory Diseases.

This issue of Medical Clinics of North America, guest edited by Dr. Otto Costantini, is devoted to Cardiac Arrhythmias. Articles in this important issue include: Basic principles of cardiac electrophysiology; The electrocardiogram: Still a useful tool in the primary care office; Palpitation: Extended electrocardiogram monitoring: Which tests to use and when; Inherited cardiac arrhythmias/channelopathies; Antiarrhythmic drugs: Benefits and risks; Stroke prevention in atrial fibrillation: Anticoagulants and/or devices; Pharmacologic and non-pharmacologic management of atrial fibrillation; Supraventricular tachycardia; Ventricular tachycardia with and without structural heart disease; Cardiac Devices: Pacemakers, Defibrillators and Biventricular Devices; Brady-arrhythmias; When is syncope arrhythmic?; Sudden Cardiac Death: Who is at risk?; and Arrhythmias and Congenital Heart Disease. A CME program is also available for this title.

The Must-Have Guide for Navigating the ICU. The House Officer's Guide to ICU Care is an eminently practical handbook for junior house officers, medical students, PAs, and nurses that offers nuts-and-bolts guidelines for optimal management of medical and surgical patients in the ICU setting. Using clear, straightforward language, the authors methodically guide clinicians through the decision-making process, first by outlining the pathophysiology of abnormalities seen in the ICU and then by explaining the principles underlying today's therapeutic measures and describing how these agents and devices are used to ensure safe patient recovery. While the text focuses on the postoperative cardiothoracic surgery patient, the principles and therapies covered are broadly relevant to all medical and general surgery ICU patients. This third edition has been thoroughly updated to include the newest diagnostic and treatment technologies, procedures, and practices, and covers everything the house officer needs to know to deliver safe, effective, front-line care - especially during those times when senior staff are not there to rely on. Updated references, self-assessment tools, and an Emergency Response Sheet of essential paradigms, drugs, and doses will ensure confident decision-making when it counts the most. For the house officer, this book gives you everything you need to know, and not a word more. Especially useful for: house officers and medical students embarking on ICU responsibilities,intensive care nurses and nurses in training physicians' assistants,and respiratory therapists.

This issue of Sleep Medicine Clinics focuses on Dental Sleep Medicine and includes topics on: Clinical Evaluation for Oral Appliance Therapy; Bruxism and Obstructive Sleep Apnea; Obstructive Sleep Apnea's Connections with Clinical Dentistry; Avoiding and Managing with Oral Appliance Therapy Side Effects; Predicting outcomes with Oral Appliance Therapy; Oral Appliance Therapy and Temporomandibular Disordres; Dental Sleep Medicine in the Military; and Pediatric Considerations in Dental Sleep Medicine

Get a quick, expert overview of the many key facets of lung cancer evaluation and management with this concise, practical resource by Drs. Lynn T. Tanoue and Frank Detterbeck. This easy-to-read reference presents a summary of today's best evidence-based approaches to diagnosis and management in this critical area.

This issue of Chest Medicine Clinics focuses on Respiratory Manifestations of Neuromuscular and Chest Wall Disease, with topics including: Respiratory Pathophysiology of CW; Respiratory Pathophysiology of NMDiseases; Sleep Disordered breathing in NMDs and CW; PFT Measurements in NMD and CW disorders; Assessing diaphragm function in chest wall and neuromuscular disease; Disorders of the Diaphragm; Disorders of the CW; Muscular Dystrophies; Respiratory Issues in Amyotrophic Lateral Sclerosis; Metabolic myopathies and the Respiratory System; Respiratory complications of SCI; Obesity hypoventilation syndrome; NIV in NMD and CW; Swallowing and Secretion Management Issues in Neuromuscular Disease; Advances in Cell and Molecular Biology in NMD; and Diaphragm Pacing.

Lung cancer is the neoplastic disease with the highest mortality numbers in the world. The disease is very common in industrialized countries. This textbook synthesizes the basic science of lung cancer with state-of-the-art accounts of diagnosis and treatment. Written by a distinguished panel of experts from Europe, Asia, and North America, it covers all of the most important fields: biology, pathology, epidemiology, screening, diagnosis, therapy, supportive care, and prognosis. All physicians caring for patients with lung cancer, especially surgeons, chest physicians, radiation oncologists, and medical oncologists, will find a wealth of information that meets their needs. Whenever possible, the principles of evidence-based medicine are followed by providing data from systematic reviews, meta-analyses, methodology-based guidelines, and randomized clinical trials.

Early in 2008, doing ordinary, mundane things like tying his shoes and walking up steps literally took author Jim Uhrig's breath away. He had trouble breathing, and it seemed as though he could never catch his breath. That was the beginning of a long journey for Uhrig, who shares his story in Partners 4 Life. In this memoir, he narrates the path his life took after being diagnosed with the incurable idiopathic pulmonary fibrosis and undergoing a subsequent lung transplant in April of 2009. Uhrig not only discusses his diagnosis and treatment, but also places special emphasis on the partners-from his personal life, his business, and his sports activities-who provided him with inspiration and help and played an integral role in his survival. He includes his partners in medicine, the donor and her family, caregivers, and special angels. Uhrig's story relates how he tackled his lung disease and transplant with the same fervor he lived life. Partners 4 Life communicates the saving grace of an organ transplant as well as the power of positive thinking.

What are the different muscarinic acetylocholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in inflammatory mechanisms and in neurogenic and non-neurogenic control of the airways? How is their gene expression regulated? The importance of muscarinic acetylocholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. This book seeks to meet this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptor in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the long-acting M3 and M1 receptor-selective antagonist tiotropium bromide. The modulation of muscarinic receptor function and cholinergic vagal nerve activity by neurogenic and non-neurogenic inflammatory pathways is dealt with and emphasis laid on the potential importance of these mechanisms to the pathophysiology of asthma and COPD. This book is a reference for pulmonologists and medical, physiological and pharmacological scientists involved in airways research, to whom it offers an update of recent developments in the physiology, pathophysiology, pharmacology and therapeutics of the cholinergic system in the airways and a scientific basis for further research in this field.

This issue of Clinics in Chest Medicine focuses on Current Perspectives on the Diagnosis and Treatment of Fungal Chest Infections.Editors Andrew Limper and Eva Carmona have assembled an expert team of authors on topics such as: When to consider the possibility of a fungal infection: an overview of clinical diagnosis and laboratory approaches; Overview of treatment approaches for fungal infections; Clinical perspectives in the diagnosis and management of histoplasmosis; Presentation and management of coccidiodomycosis in immune competent and immunosuppressed patients; Clinical manifestations and treatment of blastomycosis; Update on the epidemiology, diagnosis, and treatment of cryptococcal infections; Approach to fungal infections in HIV-infected individuals: Pneumocystis and beyond; Fungal infections in immunocompromised patients with malignancies: practical approaches to prevention, diagnosis, and treatment; Candidemia in the intensive care unit; Fungal infections following lung transplantation; Noninvasive aspergillus infections and syndromes; Contemporary laboratory modalities for the diagnosis of fungal infections; Emergence of the molds other than Aspergillus in immunocompromised patients.

This book reviews stem cell behavior in the lung as it relates to regenerative medicine and stem cell therapeutics. Topics ranging from basic developmental mechanisms of various types of lung stem cells through the identification and properties of stem cell behavior and their potential applications in lung repair and regeneration, are discussed by an expert in the field. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding of developmental lung stem cell biology and behavior and their potential applications. Lung Stem Cell Behavior is essential reading for researchers in stem cell biology and regenerative medicine, patient advocates, undergraduate students, graduate students, and clinicians interested in cellular therapy and tissue engineering therapies.

Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung's innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.

This issue of Clinics in Chest Medicine focuses on Viral and Atypical Pneumonia. Editors Charles Dela Cruz and Richard Wunderlink have assembled an expert team of authors on topics such as: Epidemiology of Viral Pneumonia; Diagnostic Testing for Viral and Atypical Infections;Lung Microbiome: Atypical Infections and Viruses; RSV Pneumonia in the Young and Old;Viral infections in Chronic Lung Diseases; Viral Pneumonia and ARDS;Viruses in the Immunocompromised; Atypical Bacterial Pneumonia; Other Community Respiratory Viruses; Pandemic Viruses; Epidemic and Emerging Coronaviruses; Post-Viral Complications; Antiviral Treatments; and Vaccines in the Prevention of Viral Pneumonia.