Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger (e.g., micrometer) particles, are considered to behave differently when they interact with cells. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery provides a better understanding of how inhaled nanoparticles behave in the human lungs and body. Featuring contributions from renowned subject-matter experts, this authoritative text describes the sequence of events that nanoparticles encounter in the lungs when moving from the air into the bloodstream. This includes deposition, interactions with the alveolar surface and epithelium, translocation across the air-blood tissue barrier, and accumulation in the body. In addition, the book addresses practical considerations for drug delivery to the respiratory tract, drug and gene delivery in the lungs, and bio-nanocapsules. It considers the physicochemical, colloidal, and transport properties of nanoparticles, and presents cutting-edge research on special issues such as dosimetry for in vitro nanotoxicology, nanoparticle deposition in the developing lungs, and the potential for nose-to-brain delivery of drugs. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery offers the most updated and comprehensive knowledge of the risks and benefits associated with nanoparticle inhalation-to protect humans from any harmful effects and to explore the utility of nanoparticles as drug delivery carriers.

Comprehensive Tracheostomy Care is a resource developed by the UK National Tracheostomy Safety Project (NTSP) to help promote and facilitate the safe management of tracheostomies and laryngectomies. The scope includes hospital in-patient specialist areas such as critical care, head & neck units and specialist wards, but it is also applicable to more general wards, outpatient and community settings. The majority of the content is for adult patients, complemented by a dedicated paediatric chapter developed with colleagues from Great Ormond Street Hospital. The manual is a one stop shop covering all aspects of tracheostomy and laryngectomy management. It includes multidisciplinary resources from surgical, anaesthetic, nursing, intensive care and allied health backgrounds, along with guidance from key UK stakeholder organisations. Emergency guidance has been reviewed and endorsed by relevant Royal Colleges, national organisations and patient groups. It takes into account many national and international guidelines, policies and resources. It has been developed by consulting as widely as possible, across traditional professional boundaries using expertise and existing guidance from around the world, including the Global Tracheostomy Collaborative (www.globaltrach.org). Relevant existing resources are brought together coherently, with new resources presented in easy-to-follow text, illustrations, photographs and innovative linked e-learning and interactive resources.

Starting with patient assessment, the authors explain the physiological basis of all major cardiopulmonary problems before describing the physiotherapy interventions possible - this ensures the reader understands why the problems occur and not just how to treat them. The book concludes with a detailed glossary, an appendix describing all the treatment methods required, and a final section provides case studies to enhance problem-based learning. The unique combination of physiology, the latest evidence, and detailed methodologies and case studies, ensures that Cardiopulmonary Physiotherapy is an essential purchase for all undergraduates. Postgraduate students in their first years of training will also benefit from quick access to the core information they need on a daily basis.

Using a multidisciplinary approach, Human Respiratory Viral Infections is set at the level between the definitive reference work and an essential clinical manual. Exploring recent advances in human respiratory viral research, the text builds on the basic sciences of epidemiology, virology, molecular biology, and immunology to cover clinical diagnosis, mechanism of pathogenesis, manifestations of disease, impact, treatment, and management strategies. Provides a comprehensive review of all the major human respiratory viral infections Supplies a detailed description of the anatomy of the respiratory system Discusses the salient features of specific viruses Examines the latest diagnostic tools Covers risk factors associated with incidence of respiratory viral infections in children and adults in different occupational and environmental settings Presenting the latest knowledge in human respiratory viral infections, this text will be immensely valuable for pulmonologists, biomedical scientists, research scholars, virologists, vaccinologists, immunologists, clinicians, pharmacologists, and public health specialists.

This Workbook is designed to reinforce the essential concepts presented in Clinical Application of Mechanical Ventilation, and give learners practice with questions written in NRBC format. With a concise and easy-to-read approach, the new edition of this book integrates the essential concepts of respiratory physiology with the clinical application of mechanical ventilation. Extensive coverage of airway management and weaning criteria, and a concise view of pharmacotherapy for mechanical ventilation are included. This edition features new material on special procedures in mechanical ventilation, chest tubes and placement, proportional pressure support, airway management, and ventilator waveform analysis.

Concise yet comprehensive, this textbook of clinical pulmonology provides pulmonologists and respiratory disease physicians with all the key information that they need to know to manage the patient through the diagnosis and treatment journeys. From the most common condition to the rarest, each disease is consistently presented and comprehensively covered giving the reader just the key facts. Building upon the basic sciences and integrating these with clinical practice, each chapter has a consistent approach, is highly designed and visually appealing. Numerous illustrations, colour photographs, scans, bullet points, tables and algorithms ensure that the key information is available at a glance. The keynote sections serve as a useful revision aid as do the multiple choice questions. A truly international and highly experienced editorship with expert contributors from around the world ensure that the book remains a trusted source of information. Set at the level between the definitive reference work and the clinical manual, Essentials of Clinical Pulmonology is an invaluable cornerstone for all pulmonologists whether trainees or experienced clinicians.

The health-related effects of asbestos have long been mired in controversy, with industry and plaintiff attorneys playing a significant role. This comprehensive book provides a balanced and extensive evidence-based critical analysis of the literature concerning asbestos-related diseases, from a scientific and historical perspective. The book presents a carefully referenced review of the medical literature on the health effects of asbestos, and reflects the extensive experience of the author in evaluating patients with asbestos-related disorders.

The COPD chart presents a detailed overview of the symptoms and causes of Chronic Obstructive Pulmonary Disorder (COPD). Sections help explain the two related respiratory diseases that constitute COPD - emphysema and chronic bronchitis. Heavy cover stock with protective varnish for durability.

Most of us pay little attention to the workings of our lungs but the COVID-19 pandemic has sparked interest in their functioning and fear about the risks they face. Dr MeiLan K. Han, a leading pulmonologist and a national spokesperson for the American Lung Association, takes readers on a fascinating tour of this most vital organ. Han explains the wonder of breathing and reveals how the lungs serve as the body's first line of defence. She provides a timely overview of the latest scientific thinking about the leading respiratory risks-including indoor and outdoor pollution, smoking and vaping, wildfire smoke and viruses like SARS-CoV-2-and offers a practical guide to keeping lungs healthy. With authority as both practitioner and medical researcher, she argues powerfully for a social policy that makes a priority of preserving lung health nationwide.

This timely Second Edition of a landmark reference furnishes in-depth examinations of the latest developments in the physiology, pathophysiology, and clinical relevance of the respiratory muscles and chest wall-reflecting the explosion of information that has occurred since the publication of the previous edition.

Bronchitis and emphysema affect some three million people in the UK, and kill 30,000 people each year. They account for more loss of time from work than any other form of illness, and are usually caused by smoking, which leads to inflammation of the bronchi. As the lungs become increasingly damaged, shortness of breath develops even on moderate exertion, such as climbing stairs. As the condition worsens, simple tasks such as washing or shaving cause marked shortness of breath, and eventually fighting for breath occurs even at rest. The condition cannot be cured. However, further deterioration can be prevented, and this new edition brings us up to date with changes in treatment, though stopping smoking is still key. Difficulty in breathing can be eased by using inhalers or nebulisers which deliver drugs that open up the airways called bronchodilators (eg Ventolin'). Inhaled steroids (eg Becotide') are useful in reducing inflammation of the air tubes. Many people need to have oxygen several times a day, and dust, fumes and pollution should be avoided. Lifestyle changes may also help, such as losing weight and taking exercise.

This authoritative reference reviews current and emerging molecular imaging modalities that are expected to impact the detection and treatment of lung diseases in the near future-including applications in gene expression and inflammation imaging; the imaging of pulmonary cytokine regulation; the molecular imaging of angiogenesis, the airways, and lung cancer; and the imaging of cellular death and cell trafficking.

Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease specifically addresses the cardiovascular and cerebrovascular consequences of sleep apnea and is geared toward a broad readership of physicians that will ultimately aid patients suffering from sleep apnea.

The Second Edition ensures that there is a critical synthesis of existing literature and new information, linking sleep apnea to the major disease burdens faced by developed and developing nations. This synthesis includes both new basic and epidemiological data and published clinical trials linking sleep apnea to:

• inflammation
• the metabolic syndrome
• stroke
• hypertension and heart failure

Written by internationally recognized experts, Pulmonary Hypertension bridges the gap between pulmonology and cardiology to provide clinicians in both disciplines with knowledge of the signs, symptoms, diagnosis, and pharmacologic and surgical treatments for pulmonary hypertension (PH). Through the use of clinical trials, this ground-breaking text supplies a comprehensive review of both the primary and secondary clinical and investigative aspects of this condition.

Discussing controversies and concepts in PH diagnosis and management, this guide explores:

• classification and epidemiology, pathology, pathogenesis, genetics, and diagnosis of PH
• causes of the condition, such as idiopathic pulmonary arterial hypertension (IPAH)
• PAH-complicating connective tissue diseases (CTD), congenital heart diseases, human immunodeficiency virus (HIV), and other disorders
• the mechanisms, toxicities, and efficacy of therapeutic agents
• the role of combination therapies, novel agents, and future directions
• PH in specific patient populations such as pregnant and critically-ill patients in the ICU

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition. Integrates basic science into individual cancer chapters for more efficient reference Features quarterly updates that include late-breaking developments in oncology such as new drugs and clinical trials, as well as new case studies and interactive algorithms Offers balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist Provides updated content on immunotherapy and genetics throughout Includes important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues Now available in a convenient single volume, or a seven-multivolume option for portability and ease of use Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Providing a solid foundation for specialists in asthma treatment and control, this guide illustrates the importance of asthma monitoring practices for up-to-date assessments of disease levels in specific population groups; the identification of social, geographical, and environmental factors that may influence the development of asthma; and the design of improved and cost-effective prevention and management strategies for optimal patient care.

The book presents a comprehensive overview of the various disease processes affecting the chest and related abnormalities. It discusses biopsy and bronchography, as well as a variety of imaging techniques including radiography, fluoroscopy, tomography, and ultrasound.

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

Arthur McIvor and Ronald Johnston explore the experience of coal miners' lung diseases and the attempts at voluntary and legal control of dusty conditions in British mining from the late nineteenth century to the present. In this way, the book addresses the important issues of occupational health and safety within the mining industry; issues that have been severely neglected in studies of health and safety in general. The authors examine the prevalent diseases, notably pneumoconiosis, emphysema and bronchitis, and evaluate the roles of key players such as the doctors, management and employers, the state and the trade unions. Throughout the book, the integration of oral testimony helps to elucidate the attitudes of workers and victims of disease, their 'machismo' work culture and socialisation to very high levels of risk on the job, as well as how and why ideas and health mentalities changed over time. This research, taken together with extensive archive material, provides a unique perspective on the nature of work, industrial relations, the meaning of masculinity in the workplace and the wider social impact of industrial disease, disability and death. The effects of contracting dust disease are shown to result invariably in seriously prescribed lifestyles and encroaching isolation. The book will appeal to those working on the history of medicine, industrial relations, social history and business history as well as labour history.

Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source spans the latest developments in the utilization of microarray techniques, linkage and association studies, mapping strategies, comparative genetics, microarray techniques, proteomics, and pharmacogenomics.

Specifically focusing on the immediate management and diagnosis of patients in the intensive care unit, this reference contains expert reviews and practical care recommendations for patients with acute respiratory failure. Packed with detailed descriptions of treatment procedures and quality figures throughout each chapter, Practical Pulmonary and Critical Care Medicine will stand as a must-have armamentarium of protocols and guidelines for efficient and effective patient care.

Filling a gap in the literature, this reference provides concise and practical guidelines for the diagnosis and management of sinusitis and furnishes an authoritative outline of our current understanding of the pathophysiology of this condition. Addressing a wide spectrum of issues related to the identification, epidemiology, and etiology of sinusitis, this guide presents detailed illustrations and flowcharts to clarify the interactions between the pathological and physiological processes of sinusitis and illustrate current treatment practices.

Providing a solid foundation for specialists in asthma treatment and control, this guide illustrates the importance of asthma monitoring practices for up-to-date assessments of disease levels in specific population groups; the identification of social, geographical, and environmental factors that may influence the development of asthma; and the design of improved and cost-effective prevention and management strategies for optimal patient care.

Written by world authorities, this reference explores the utilization and advancement of state-of-the-art imaging modalities for the analysis of pulmonary function-providing an up-to-date and global perspective of imaging applications with detailed contributions from experts in Europe, North America, Japan, and Australia.