Drs. Robert Kotloff and Francis McCormack have assembled an expert team of authors on the topic of Rare and Orphan Lung Diseases. Articles include: Lymphangioleiomyomatosis, Pulmonary Lymphangiomatosis, Langerhans Cell Histiocytosis and other Histiocytic Diseases of the Lung, Pulmonary Alveolar Proteinosis, Pulmonary Alveolar Microlithiasis, Primary Ciliary Dyskinesia, Birt-Hogg-Dube Syndrome, Hermansky-Pudlak Syndrome, Hereditary Hemorrhagic Telangiectasia, Non-CF Bronchiectasis, Eosinophilic Lung Diseases, Benign Metastasizing Leiomyomata, and more!

This issue of the Cardiology Clinics entitled "Pulmonary Hypertension" is an in-depth review on the subject edited by Dr. Ronald J. Oudiz. The topics covered will include: classification of pulmonary hypertension, epidemiology and pathophysiology, diagnosis, and management in Groups I-V. There are also sections devoted to issues faced in pediatrics and pregnancy, as well as a section on patient support, among other topics.

This issue of Clinics in Chest Medicine focuses on Sepsis. Articles include: The changing epidemiology and definition of sepsis; risk stratification and prognosis in sepsis: what have we learned from biomarkers and microarrays?; Sepsis outside the ICU: development and implementation of sepsis alert systems; The use of ultrasound in caring for the septic patient; Sepsis resuscitation: Fluid choice and dose; Beyond the golden hours: caring for the septic patient after the initial resuscitation; Vasopressors during sepsis: selection and targets; Dysglycemia and glucose control during sepsis; Cardiac function and dysfunction in sepsis;Goal Directed Resuscitation in Septic Shock; and more!

The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.

This issue of Immunology and Allergy Clinics of North America, guest edited by Dr. Rohit Katial, is devoted to Severe Asthma. Articles in this issue include: Epidemiology and Pulmonary Physiology of Severe Asthma; Linkage and Genetic Associations in Severe Asthma; Asthma COPD Overlap Syndrome (ACOS); Biomarkers in Severe Asthma; Imaging in Severe Asthma; Eosinophilic Phenotype; Neutrophilic and Pauci-immune Phenotypes; Role of Sleep Apnea and Gastroesophageal Reflux Disease in Severe Asthma; Role of Small Airways in Severe Asthma; Chronic Infection and Severe Asthma; Chronic Rhinosinusitis and Aspirin Associated Respiratory Disease; Psychosocial Factors in Severe Asthma; Traditional Therapies for Severe Asthma; and Emerging Biologics for Severe Asthma.

This issue of Immunology and Allergy Clinics of North America, guest edited by Dr. Jonathan A. Bernstein, is devoted to Rhinitis. Articles in this issue include: Rhinitis Subtypes, Endotypes, and Definitions; Allergic Rhinitis: Burden of Illness, Quality of Life and Control; Allergic Rhinitis: Mechanisms of Action; Allergic Rhinitis: Diagnosis; Allergic Rhinitis: Treatment; Non-allergic Rhinitis: Mechanism of Action; Non-allergic Rhinitis: Diagnosis; Non-allergic Rhinitis: Treatment; Localized Allergic Rhinitis; Occupational Rhinitis; Rhinitis in the Elderly; Complications of Rhinitis; Allergic Rhinitis: Environmental Determinants; Non-allergic Rhinitis: Environmental Determinants; and Novel, Alternative, and Controversial Therapies.

This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.

The third of a series of Multispecialty presentations in plastic surgery is this issue on Rhinoplasty, led by Dr. Babak Azzizadeh with plastic surgery section editor Dr. Ronald Gruber and facial plastic surgery section Editor Dr. Daniel Becker. This comprehensive publication on all aspects of Rhinoplasty and Revision Rhinoplasty presents clinical management from plastic surgeons and facial plastic surgeons on topics including: Anatomy/Analysis of the Nose in Rhinoplasty; External and Endonasal Rhinoplasty; Airway Obstruction; Surgical Treatment of Nasal Obstruction in Rhinoplasty; Cleft Lip Nose; Humpectomy/Spreader Flaps; Costal Cartilage Grafts in Rhinoplasty; Nasal Bones and Osteotomies; Dorsal Hump Osteotomies; Dorsal Augmentation; Short Nose Correction; Nasal Tip Deficiency; Projection and De-projection Techniques in Rhinoplasty; Projection and De-projection in Rhinoplasty; Use of Fillers in Rhinoplasty; Surgical Treatment of the Middle Nasal Vault; Bulbous and Broad Nasal Tip; The Crooked Nose; Surgical Treatment of the Twisted Nose; Nasal Base Deformities; Alar Rim Deformities; Rhinoplasty in the Asian Patient; Rhinoplasty in the African-American Patient; Rhinoplasty in the Latino Patient; Revision Rhinoplasty; Chin Advancement, Augmentation, and Reduction as an Adjunct to Rhinoplasty.

Bronchopulmonary dysplasia (BPD) as a chronic lung disease affecting preterm infants has been recognized for more than 45 years. However, little progress has been made in the prevention and treatment of the disease. BPD continues to be a major morbidity affecting preterm infants. Studies in pre-adolescent children demonstrate that the abnormal lung function from BPD persists well into childhood. Infants with BPD also have an increased risk for adverse neurodevelopmental outcome. Thus BPD imposes a significant burden of adverse health outcomes in preterm infants. The major risk factors for BPD are prematurity, mechanical ventilation, exposure to noxious insults such as oxygen, infections. New research data both in basic science and clinical studies have shed light on the pathogenesis, and possible new treatment or management strategies for the future. In the proposed issue of the Clinics in Perinatology, we would like to comprehensively cover BPD both from a basic science and clinical perspective. Our attempt is to balance new information along with classic topics. The proposed authors for the issue are recognized experts in the topic area/s. We hope that the issue will be of interest to a broad array of readership.

This volume summarizes current techniques; ranging from protocols for virus growth, isolation, quantification and generation of recombinant RSV virus to procedures for the efficient characterization of the host immune response to RSV infection. These techniques are used in numerous laboratories around the world and are the building blocks that support the majority of RSV virus research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Humana Respiratory Syncytial Virus: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Drs. Honiden and Siner have put together a comprehensive issue on Critical Care as it relates to Chest Medicine. Articles include:Recent advances in management of Acute respiratory distress syndrome, Simulation training for critical care, Telemedicine (E-ICU issues), Adverse event reporting/quality improvement in the ICU, ICU Mobility, Hospital-acquired infections/resistant organisms/emerging pathogens, Circadian rhythm disturbance and sleep in the ICU environment, Advances in Sepsis Research, Controversies in ICU nutrition, and more!

This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation. Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.

In the last 100 years, there have been three major influenza pandemics: the Spanish Flu in 1918, the Asian Flu in 1957, and the Hong Kong Flu in 1968. These pandemics claimed the lives of approximately 50 million, 2 million, and 1 million people respectively. Added to this is the annual death toll from influenza of 250,000 to 500,000 people worldwide, with a further 3 to 4 million people suffering severe illness. These statistics make influenza an extremely important pathogen. In 1997, the alarming emergence of a new, highly pathogenic subtype, H5N1, which has a 50% mortality rate, provided a major impetus for renewed influenza research. However, the battle against influenza is difficult. Recently another subtype, H1N1, has emerged. This subtype causes a relatively mild infection in humans, however it is highly transmittable between people and a new influenza pandemic has been declared by the World Health Organization. If this virus were to acquire some of the lethal capabilities of H5N1, then the ensuing pandemic could be devastating. In this timely book, internationally renowned scientists critically review the current research and the most important discoveries in this highly topical field. Subjects covered include the NS1 protein of influenza A virus, the structure of influenza NS1, influenza B hemagglutinin, influenza A nucleoprotein, influenza A hemagglutinin glycoproteins, the M2 channel, virulence genes of the 1918 H1N1 influenza, influenza virus polymerase, gene diagnostic microarrays, and computer-assisted vaccine design. Highly informative and well referenced, Influenza: Molecular Virology is essential reading for all influenza specialists and is recommended reading for all virologists, immunologists, molecular biologists, public health scientists, and research scientists in pharmaceutical companies.

The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.

Clinics Collections: Chronic Obstructive Pulmonary Disease draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, pulmonologists, sleep specialists, radiologists,and critical care nurses, with practical clinical advice and insights on this highly prevalent condition and its comorbidities. Clinics Collections: Chronic Obstructive Pulmonary Disease guides readers on how to apply current primary research findings on lipid disorders to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. . Areas of focus include pathogenesis, COPD and secondary disorders, clinical considerations and complications, treatment and pharmacotherapy, and special considerations. . Each article begins with keywords and key points for immediate access to the most critical information. . Articles are presented in an easy-to-digest and concisely worded format. Elsevier's Clinics Collections provide concise reviews of today's most prevalent conditions and significant medical developments. Other Clinics Collections titles available include Type II Diabetes Mellitus, Asthma, Obesity, Pain Management, and Lipid Disorders.

This issue of Clinics in Chest Medicine focuses on Chest Imaging. Drs. Lynch and Chung have assembled an expert panel of authors on the topics of:Approach to chest CT, CT screening for lung cancer,The solitary pulmonary nodule, Staging of lung cancer, Imaging of infections, ICU imaging, Pulmonary vascular diseases, Occupational and environmental lung disease, Idiopathic interstitial pneumonias, Connective tissue disease-related thoracic disease and more!

The lungs are involved so frequently with rheumatologic problems. This issue will cover Radiology of lung disease in the rheumatic diseases, Histopathology of lung disease in the rheumatic diseases, Determining respiratory impairment, Lung disease in RA, Lung disease in scleroderma, and many more!

This book provides a comprehensive framework for treatment and management of bronchopulmonary dysplasia. In recent years great strides have been made toward understanding the pathogenesis and clinical aspects of BPD, which is the most common chronic lung disease affecting infants. This one-stop resource is written by leading scientists and clinicians in the field, and chapters discuss the most recent developments in the basic scientific, translational, and clinical characteristics of the disease. Topics such as hyperoxia, pre- and post-natal inflammation, and genetics and biomarkers of BPD are included, as well as non-invasive ventilation techniques, nutrition, and radiology applications from pre-term birth to adulthood. The book closes with an in-depth look at emerging therapeutic options for prevention of BPD. Bronchopulmonary Dysplasia is an essential volume for all neonatologists, pediatric pulmonologists, and scientists interested in developmental disorders of the lung.

1. Prevention and Early Detection of Lung Cancer - Clinical Aspects.- 2. Smoking Prevention and Cessation.- 3. Clinical Pharmacology of Vitamin A and Retinoids.- 4. Early Lung Cancer Detection.- 5. Molecular Abnormalities in the Sequential Development of Lung Carcinoma.- 6. Application of In Situ PCR and In Situ Hybridization to the Characterization of Lung Cancers.- 7. Tumor Stroma Formation in Lung Cancer.- 8. Tumor Angiogenesis: Basis for New Prognostic Factors and New Anticancer Therapies.- 9. Cell Cycle Regulators and Mechanisms of Growth Control Evasion in Lung Cancer.- 10. Molecular Genetics of Lung Cancer.- 11. Neuropeptides, Signal Transduction and Small Cell Lung Cancer.- 12. In Vitro Analysis of Bombesin/Gastrin-Releasing Peptide Receptor (bb2) Ligand Binding and G-Protein Coupling.- 13. DNA Methylation Changes in Lung Cancer.- 14. K-ras Mutations as Molecular Markers of Lung Cancer.- 15. Sheep Lung Adenomatosis: A Model of Virally Induced Lung Cancer.- 16. Retinoic Acid Receptor ss An Exploration of its Role in Lung Cancer Suppression and its Potential in Cancer Prevention.- 17. Cytochrome P450 Polymorphisms: Risk Factors for Lung Cancer?.- 18. Glutathione S-Transferases and Lung Cancer Risk.- 19. The p53 Tumor Suppressor Gene in Lung Cancer: From Molecular to Serological Diagnosis.- 20. Endoscopic Localization of Preneoplastic Lung Lesions.- 21. Antigen Retrieval Improves hnRNP A2/B1 Immunohisto-chemical Localization in Premalignant Lesions of the Lung.- 22. Molecular Pathological Mechanisms in NSCLC and the Assessment of Individuals with a High Risk of Developing Lung Cancer.- 23. Chemoprevention of Lung Cancer.- 24. Regional Delivery of Retinoids: A New Approach to Early Lung Cancer Intervention.- 25. Natural Inhibitors of Carcinogenesis.- 26. Gene Delivery to Airways.- 27. Lung Cancer Prevention: The Point of View of a Public Health Epidemiologist.- 28. Biomarkers as Intermediate Endpoints in Chemoprevention Trials: Biological Basis of Lung Cancer Prevention.- 29. Biological Tools for Mass Screening.- 30. Optimization of the Use of Biological Samples for the Prospective Evaluation of Preneoplastic Lesions.

Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung.

Drs. Huitt and Daley have assembled an expert panel of authors on the topic of Non-Tuberculosis Mycobacteria. Articles in this issue will include discussions in the following areas: The Pathogenesis of NTM, Epidemiology of NTM, Environmental Sources of NTM, Laboratory Diagnosis of NTM, Medications and Monitoring in NTM infections, Treatment of Rapidly Growing NTM, Treatment of Slow Growing NTM, NTM Infections in Immunocompromised Hosts, Extra Pulmonary NTM Infections, NTM Infections in Cystic Fibrosis, and Surgical Approach to NTM Infections.

Lung Transplantation is covered in detail in this important issue of the Thoracic Surgery Clinics. Articles include: Candidacy for Lung Transplant and Lung Allocation; ECMO as Bridge to Lung Transplant; Single Versus Double Lung Transplant: Do Guidelines Exist?; Extending the Donor Pool: Donation After Cardiac Death; Extending the Donor Pool: Rehabilitation of Poor Organs; Bronchial Artery Revascularization; Anastomotic Airway Complications Following Lung Transplantation: Implications and Interventions; Pleural Space Complications Associated with Lung Transplantation; Reflux and Allograft Dysfunction, Is there a Connection?; Artificial Lungs: Are We There Yet?; and more.

This issue of Clinics in Chest Medicine focuses on Acute Respiratory Distress Syndrome and covers topics such as: Epidemiology and Definitions of ARDS and Early Acute Lung Injury, Environmental Risk Factors for ARDS, Clinical and Biological Heterogeneity in ARDS: Direct vs. Indirect Lung Injury,Obesity and Nutrition, Important Immunomodulators in ARDS?, Beyond SNPs-Genetics, Genomics and Other Omic Approaches to ARDS, Clinical Approach to the Patient with ARDS, The Immunocompromised Patient with ARDS: Role of Invasive Diagnostic Strategies, Clinical Trial Design in Prevention and Treatment of ARDS, Beyond Low Tidal Volume-Ventilating the Patient with ARDS, Prone Positioning in ARDS, and more!