Written by world authorities, this reference explores the utilization and advancement of state-of-the-art imaging modalities for the analysis of pulmonary function-providing an up-to-date and global perspective of imaging applications with detailed contributions from experts in Europe, North America, Japan, and Australia.

Emphasizing the impact of air toxins and contaminants on human health, this Second Edition examines the latest research from the epidemiology to the cellular mechanisms underlying cardiopulmonary responses to air pollution. This guide offers chapters that address the basic biology, techniques, and clinical practices used to monitor and assess acute and chronic pollutant responses; the effects of specific air toxins and contaminants on various populations chronically exposed to these compounds; and the complex issues associated with translating science to public health policy. This Second Edition offers a current and timely review of the effects of ambient air pollution on the human cardiopulmonary system provides new chapters on particulate matter (PM) air pollution, including particulate dosimetry of the respiratory system, genetic factors in the cardiopulmonary response to PM, PM-induced airway remodeling, and combustion emissions and their relation to cancer furnishes sections by chapter contributors with in-depth expertise in various areas of indoor and outdoor air pollution research maintains a balance between traditional topics and the review of current information showcasing the growing interest in the neuronal and cardiovascular effects that result from the exposure of human populations to PM air pollution crosses several scientific disciplines including epidemiology, toxicology, physiology, and public health presents the evolution of federal legislation and standards for air pollution emissions including the scientific rationale for these regulations

The only source to describe the lung surfactant as a complex membranous system, this guide analyzes lung surfactant function from the aspects of molecular biology, biophysics, membrane science, and surface and interface analysis and reviews the latest basic and clinical issues relating to lung disease and (dys)function.

Complete Guide to Respiratory Care in Athletes introduces the respiratory system and its function during exercise. It considers the main respiratory conditions affecting athletes and delivers practical advice for the management of respiratory issues in athletic populations. With contributions from leading international experts, the book discusses fundamental scientific principles and provides pragmatic 'hands-on' clinical guidance to enable practical application. Each chapter includes useful pedagogical features such as case studies and guides for carrying out assessments. The book covers wide a range of topics, including: respiratory system function during exercise impact of the environment on the upper and lower airways asthma related issues in athletes allergic rhinitis in athletes exercise induced laryngeal obstruction exercise induced dysfunctional breathing paterns respiratory muscle training role of screening for respiratory issues in athletes assessing and dealing with respiratory infections in athletes. This text is key reading for both newly qualified and established medical, scientific and therapy practitioners who are working with athletes with respiratory issues. It is also a valuable resource for students of sports medicine, sports therapy, and sport and exercise science courses.

This text analyses the pathophysiology, diagnosis, treatment and control of respiratory disorders in the newborn infant. It explores the mechanisms, patterns and factors influencing respiratory activity and dysfunction, as well as the aetiology, management and evaluation of conditions such as respiratory distress syndrome, bronchopulmonary dysplasia, airway disorders, and congenital hypoventilation syndromes.

This easy yet comprehensive reference guide covers the mechanisms of respiratory diseases, explaining the main respiratory conditions for clinicians and postgraduate trainees. It discusses their aetiology as well as the basic concepts required to effectively evaluate and treat them. Applied Respiratory Pathophysiology is the first book to bring together detailed, clinically-relevant explanation of respiratory physiological processes and pathophysiological processes in one text. It is essential reading for anyone diagnosing and treating specific clinical conditions of the lungs.

Answering the demand for acomprehensive, all-purpose volume focusing on the challenging needs of pediatric patients, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients summarizes a wealth of knowledge on the mechanical devices, clinical management, alternative applications, and future directions in the specialized field of pediatric critical care. Condensed advice from experts on the shelf offers guidance in critical intensive care settings! Combining clinical aspects with the latest experimental results, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients -examines current modalities and the best uses of mechanical support, including step-by-step techniques for extracorporeal membrane oxygenation (ECMO), ventricular assist devices (VAD), and intra-aortic balloon pumps -highlights the use of mechanical support in nonsurgical diseases such as myocarditis and cardiomyopathy, with implanted ventricular devices and in long-term follow-up care -discusses the optimal management for perioperative support in cardiac and pulmonary transplantations in children -reviews successful cases of mechanical support, including resuscitation after cardiac arrest, pediatric patients with myocarditis, and circulatory support of patients without cardiac disease -explores anticipated improvements and uses of the Berlin Heart, the Nimbus Rotary Pump, and applications of the Medos-HIA VAD in young patients -and much more! Authored by nearly 40 internationally recognized experts and containing over 500 literature references, drawings, photographs, and tables, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients is an invaluable referencefor cardiologists and pediatric cardiologists, intensivists, cardiac surgeons, pulmonologists, anesthesiologists, general pediatricians, nursing personnel, perfusionists, and medical school students in these disciplines.

Performing a thorough and detailed study of one of the most common yet less accurately understood causes of human illness, this all-inclusive reference examines the epidemiology, pathophysiology, and future treatment options for asthma and respiratory infections.
Contains up-to-date results from clinical trials of antiviral agents that explore new avenues of therapy-including interferons, ICAM-1 receptor blockades, vaccines, and mediator antagonists!

Respiratory problems are the most common cause of acute admission to hospital. A variety of diagnostic investigations are required, both for acute and clinic assessment. Making Sense of Lung Function Tests, Second Edition familiarises both trainees and more experienced clinicians with the interpretation of a range of respiratory parameters. It places lung function in a clinical context using real-life examples and provides invaluable hands-on guidance. For this second edition Consultant Respiratory Physician Jonathan Dakin and Consultant Anaesthetist Elena Kourteli are joined by Mark Mottershaw, Chief Respiratory Physiologist from Queen Alexandra Hospital, Portsmouth, all contributing a broad range of expertise and perspectives. Together they have updated the book throughout and added new chapters including an algorithm for interpretation of pulmonary function tests, exhaled nitric oxide (FENO) and cardiopulmonary exercise testing. The text offers a clear explanation of the concepts which students find difficult, including: The basis of obstructive and restrictive defects Pattern recognition of the flow volume loop Differences between TLCO and KCO Assessment of oxygenation using PO2 and SO2 The basis of Type 1 and type 2 respiratory failure Distinguishing respiratory and metabolic acidosis The relationship between sleep and respiratory failure The information is presented in an accessible way, suitable for those seeking a basic grounding in spirometry or blood gases, but also sufficiently comprehensive for readers completing specialist training in general or respiratory medicine.

This book gives a comprehensive overview on the use of image-guided radiation therapy (IGRT) in the treatment of lung cancer, covering step-by-step guidelines for clinical implementations, fundamental principles and key technical advances. It covers benefits and limitations of techniques as well as quality and safety issues related to IGRT practice. Addresses imaging simulation, treatment planning, verification, and delivery Discusses important quality assurance issues Describes current methods using specialized machines and technologies Jing Cai, PhD, is an Associate Professor of Radiation Oncology at Duke University Medical Center. Joe Y. Chang, MD, PhD, is Professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. Fang-Fang Yin, PhD, is Chief of the Division of Radiation Physics, Professor of Radiation Oncology, and Director of the Medical Physics program at Duke University.

Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel's Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners. Offers definitive, full-color coverage of basic science, diagnosis, evaluation, and treatment of the full range of respiratory diseases. Provides detailed explanations of each disease entity and differential diagnoses with state-of-the-art, evidence-based content by global leaders in the field. Contains a newly expanded section on common presentations of respiratory disease, plus new chapters on COVID-19, asthma and obesity, airplane travel, lung cancer screening, noninvasive support of oxygenation, lung microbiome, thoracic surgery, inhaled substances, treatment of lung cancer, and more. Covers hot topics such as vaping; advanced ultrasound applications and procedures; interventional pulmonology; immunotherapy; lung cancer targeted therapy; outbreaks, pandemics and bioterrorism; point-of-care ultrasound; use of high-flow oxygen, and more. Includes extensively reorganized sections on basic science, pleural disease, and sleep, with new chapters and approaches to the topics. Features more than 1,450 anatomic, algorithmic, and radiologic images (400 are new!) including CT, PET, MR, and HRCT, plus extensive online-only content: 200 procedural and conceptual videos plus audio clips of lung sounds. Brings you up to date with the latest respiratory drugs, mechanisms of action, indications, precautions, adverse effects, and recommendations, with increased emphasis on algorithms to illustrate decision making. Enhanced eBook version included with purchase. Your enhanced eBook allows you access to all of the text, figures, reporting templates, and references from the book on a variety of devices.

Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches
This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies.
Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma.
Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma
explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system
examines the role of monoclonal antibodies in allergy and asthma
describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids
investigates the controversy of different types of asthma
illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation
assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties
reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics
evaluates the relationship between improvements in laboratory results and clinical effectiveness
and more
Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical school students in these disciplines.

An up-to-the-minute reference guide for health professionals confronting pulmonary disorders in children, Pediatric Asthma offers the latest findings on this classification-defying disease and related conditions. Written by more than 20 international experts in the field, the book focuses on drug administration-issues of compliance, aerosol delivery, and pharmacokinetic differences among children-with a view toward developing new and more efficacious therapies.
Provides cutting-edge analysis for more effective diagnosis of children with asthma and improved monitoring and treatment for chronic patients
With a firm theoretical grounding and reflecting the state of the art in pharmacological research and development, Pediatric Asthma
reviews the prevalence, causes, and demographics of childhood asthma worldwide
explores determinants of the disorder in various populations-gender, age and severity of onset, atopic status, family history, and smoking
elucidates physiological factors such as airway remodeling, airway hyperresponsiveness, and persistent inflammation
describes in vivo and in vitro testing for asthma-associated allergy and the pros and cons of allergen immunotherapy
delineates the dynamics of the lung in terms of phenomena such as peak expiratory flow (PEF), forced vital capacity (FVC), and bronchial hyperresponsiveness (BHR)
highlights the importance of patient education and self-management
investigates the role that developmental psychopathologies and neurobehavioral dysfunctions may play in pediatric asthma
discusses inflammatory mediators such as cytokines, chemokines, leukotrienes, and prostaglandins
evaluates intravenous and inhaled 2 agonists for the bronchodilating treatment of acute severe asthma
and more
Featuring over 2100 references, more than 60 user-friendly tables, and a handy Appendix on clinical monitoring of childhood asthma and recommended drug dosages for its treatment, Pediatric Asthma is an indispensable resource for pediatricians, pediatric pulmonologists, and pediatric pharmacists; clinical allergists and immunologists; general and family practitioners; and graduate and medical school students in these disciplines.

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

"Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."

Respiratory problems are the most common cause of acute admission to hospital. A variety of diagnostic investigations are required, both for acute and clinic assessment. Making Sense of Lung Function Tests, Second Edition familiarises both trainees and more experienced clinicians with the interpretation of a range of respiratory parameters. It places lung function in a clinical context using real-life examples and provides invaluable hands-on guidance. For this second edition Consultant Respiratory Physician Jonathan Dakin and Consultant Anaesthetist Elena Kourteli are joined by Mark Mottershaw, Chief Respiratory Physiologist from Queen Alexandra Hospital, Portsmouth, all contributing a broad range of expertise and perspectives. Together they have updated the book throughout and added new chapters including an algorithm for interpretation of pulmonary function tests, exhaled nitric oxide (FENO) and cardiopulmonary exercise testing. The text offers a clear explanation of the concepts which students find difficult, including: The basis of obstructive and restrictive defects Pattern recognition of the flow volume loop Differences between TLCO and KCO Assessment of oxygenation using PO2 and SO2 The basis of Type 1 and type 2 respiratory failure Distinguishing respiratory and metabolic acidosis The relationship between sleep and respiratory failure The information is presented in an accessible way, suitable for those seeking a basic grounding in spirometry or blood gases, but also sufficiently comprehensive for readers completing specialist training in general or respiratory medicine.

Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.

Contents:
An introduction to inhalation toxicology; Inhalation exposure systems; Generation and characterization of gases and vapours; Generation and characterization of test atmospheres: particles and droplets; Morphology of the respiratory tract; Lung biochemistry and intermediary metabolism; Metabolic characteristics of the respiratory tract; Deposition and clearance of inhaled particles; Pulmonary retention of particles and fibres: biokinetics and effects of exposure concentrations; Regional deposition of inhaled reactive gases; Factors modifying the disposition of inhaled organic compounds; Carcinogenic responses of the respiratory tract to inhaled toxicants; Assessment of pulmonary function and the effects of inhaled toxicants; Immunological responses of respiratory tract to inhaled materials; Biological markers in the respiratory tract; Role of cytocines in pulmonary inflammation and fibrosis; Applications of behavioural measures to inhalation toxicology; Non-carcinogenic responses of the respiratory tract to inhaled toxicants; Risk assessment for inhaled toxicants.

"This outstanding resource offers comprehensive presentations of the latest basic knowledge and the most advanced research on neuropeptides of the respiratory tract covering the structure, receptors, molecular biology, and function of each important neuropeptide and examining how they relate to disease. Demonstrates the utility of immunohistochemistry, autoradiography, molecular biology, smooth muscle contraction, and glandular secretion for the study of neural function both in vitro and in vivo "

Chronic obstructive airways disease (COAD: bronchitis, emphysema and chronic asthma) is a major medical, psychological, social and economic problem. Breathlessness is one of the most distressing and disabling symptoms of COAD, and it has long been apparent that the condition results in impaired quality of life. Drawing upon sociological and psychological sources, and his own detailed research in this area, Simon Williams sesitively portrays the meaning, experience and impact of COAD. Sufferers' and their families' own accounts are used to portray the various stages and aspects of COAD, ranging from the experience of symptoms and the management of medical regimens, to the practical problems it creates in daily life and the more diffuse and intangible ways in which it impinges on social and family life. He also provides a comprehensive review of the psychosocial literature and concludes by discussing some of the policy implications for health care professionals.

'Brilliantly funny.' - Matt Lucas 'You have to read this book.' - Tim Harford 'It's funny, touching and gobsmacking in equal measure. At its heart is a breathtaking account of life on the COVID frontline.' - Jay Rayner 'Ed's journey is funny, sad, harrowing, hilarious... I STRONGLY URGE YOU TO READ THIS.' - Colin Mochrie 'Very Funny.' - Fern Brady 'I love your book Catch your Breath, it just feels so personal and so refreshing.' - Adil Ray, Saturday Live A gut punch of a memoir by a doctor - and comedian - whose job is to keep people alive by putting them to sleep. Ed Patrick is an anaesthetist. Strong drugs for his patients, strong coffee for him. But it's not just sleep-giving for this anaesthetist, as he navigates emergencies, patients not breathing for themselves and living with a terrifying sense of responsibility. It's enough to leave anyone feeling numb. But don't worry, there's plenty of laughing gas to be had. 'Very funny, very timely, scary in places. Ed writes with wit, insight, surprise and pathos. He is cutting his teeth in anaesthetics, taking people as close to death as you can take them, and then trying to wake them up again. And makes it funny. A joy to read.' - Phil Hammond

Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.

The Respiratory System chart presents a visual overview of the structures of breathing, from nasal passages to the bronchi. Additional imagery illustrates the paranasl sinuses and views of the larynx. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

Respiratory Medicine Lecture Notes covers everything from the basics of anatomy and physiology, through to the aetiology, epidemiology, symptoms and management of a full range of respiratory diseases, providing a comprehensive yet easy-to-read overview of all the essentials of respiratory medicine. Key features of this new, full-colour edition include: Updated and expanded material on chest X-rays and radiology Self-assessment exercises for each chapter A range of clinical images and scans showing the key features of each disease Fully supported by a companion website at www.lecturenoteseries.com/respiratory featuring figures, key points, web links, and interactive self-assessment questions Ideal for learning the basics of the respiratory system, starting a placement, or as a quick-reference revision guide, Respiratory Medicine Lecture Notes is an invaluable resource for medical students, respiratory nurses and junior doctors.

This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.