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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Inflammation and Lung Cancer (Hardcover, 2015 ed.)
Loot Price: R3,595
Discovery Miles 35 950
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Inflammation and Lung Cancer (Hardcover, 2015 ed.)
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In recent years there have been various discoveries connecting
inflammation and lung cancer and clearly there is growing interest
in this area of cancer research. The link between unresolved
inflammation and cancer has been well established with estimates
that 15% of cancer deaths are inflammation-related. Evidence for
this link includes the following: a) some inflammatory diseases are
associated with increased risk of cancer development; b)
inflammatory mediators are present surrounding and within most
tumors; c) overexpression of inflammatory cytokines increases
cancer development and progression in murine studies; d) inhibition
of inflammatory mediators decreases cancer development and
progression; and e) the use of non-steroidal anti-inflammatory
drugs (NSAIDs) has been found to decrease cancer incidence and
delay progression. The volume will present aspects of the
inflammatory tumor microenvironment (TME), its many roles in tumor
progression and metastasis, including creation of a hypoxic
environment, increased angiogenesis and invasion, changes in
expression of micro-RNAs (miRNAs) and an increase in a stem cell
phenotype. The book will also cover the mechanisms of inflammatory
mediators. Chronic overexpression of inflammatory mediators in the
TME, as seen in smokers and patients with non-small cell lung
cancer (NSCLC), can also lead to increased tumor initiation,
progression, invasion and metastasis. The volume will provide a
comprehensive perspective of the latest findings and summaries of
progress made regarding inflammation and its connection to lung
cancer.
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