Difficult to Diagnose Rare Diffuse Lung Disease presents the theoretical basis and practical aspects of differential diagnoses of rare lung diseases with the use of new method of probe-based confocal laser endomicroscopy (alveoscopy) of the distal respiratory region. Each chapter describes signs and symptoms of the disease and its typical and atypical manifestations. The book contains full color illustrations, including high-resolution histological microphotographs, CT-scans and confocal laser endomicroscopy images. In combination, these elements make this book an invaluable reference and guide for pulmonary researchers, pulmonologists, radiologists, and pathologists who wish to broaden their spectrum of knowledge in rare lung diseases.

Electronic cigarettes (E-cigarettes), also known as vape devices or by trade names such as JUUL, are handheld devices that aerosolize liquid commonly containing nicotine, humectants and flavorings. Used by 1 in 5 high school students in 2020, they are the most common tobacco product used by youth. E-cigarette use has been associated with a variety of health issues such as nicotine addiction, e-cigarette or vaping associated lung illness (EVALI), seizures, and increased risk of cardiovascular disease. This first-of-its-kind book begins with an introduction and background on the historical context of tobacco products. The next chapters provide an overview of the e-cigarette landscape and reviews the e-cigarette devices and solutions and the evolution of these products. This is followed by reviews of the health effects of e-cigarettes on users and non-users and includes recommendations for prevention and treatment of youth e-cigarette use. The last few chapters address the public health impact of e-cigarettes with a review of the evidence of e-cigarettes in smoking cessation. The book closes with policy and advocacy approaches and a resource page. E-cigarette and vape device use pose a public health crisis. This book contains succinct practical information and is a key reference for pediatricians as well as clinicians of all specialities. It also serves as a resource for health professionals, including tobacco dependence treatment providers and public health experts.

This book serves as the primary reference for precision medicine in the fields of pulmonary, critical care and sleep medicine by documenting principles written by experts in several aspects of precision medicine. It combines fundamental concepts of the field with state-of-the-art studies and how they translate into individual preventive, diagnostic and therapeutic plans. Precision medicine is focused on the integration of individual variability with disease prevention and treatment principles derived from population studies. This concept has risen to prominence in recent years in parallel with advances in genetics, molecular diagnostics and novel target-specific therapies. This fundamental shift in the approach to treatment has broad implications in how we prevent, diagnose and treat disease. Describing key concepts of precision medicine and relating these to pulmonary, critical care and sleep disorders is essential to educate relevant stakeholders and increase the impact of pulmonary precision medicine. The book is organized into seven sections: introduction; genetics; biomarkers; precise phenotyping; mobile health, wearables and telemedicine; precision therapeutics; and enabling widespread adoption of precision medicine. The chapters are organized with an introduction to the specific theme, followed by its basic concepts. They then delve into how these basic concepts relate to the larger theme of precision medicine, new precision medicine approaches to dealing with these problems, and key takeaway points. Liberally illustrated with images, figures, and tables, the text is thorough and intuitive for clinicians and researchers to learn the processes and applications of precision medicine. This is an ideal guide for clinicians to learn new precision medicine concepts in the fields of genetics, genomics, mobile health, and how they apply to their practice and their patients, as well as researchers seeking a basic understanding of precision medicine to assist in designing future research studies.

Documents both environmental and work-related causes of lung disease

Unlike other books on the subject, this new volume approaches occupational and environmental lung disease from the starting point of the patient who comes to the physician with respiratory symptoms. The authors recognize that potentially harmful exposures occur not only in the work environment, but also as a result of hobbies or other leisure activities, or from outdoor air pollution, and it is up the physician to identify whether a particular job or hobby is the cause of the patient's respiratory symptoms.
To help you arrive at a differential diagnosis, chapters in the book are arranged by job or exposure, and are divided into 5 sections: Personal environmentHome environmentOther indoor environmentsWork environmentGeneral environment

Each is written by an expert in the specific topic and provides pragmatic information for the practicing physician. This practical book is an invaluable resource that belongs close at hand for all physicians dealing with patients experiencing respiratory symptoms.

Imaging tests are integral to the management of patients with suspected lung disease. Staggering advances in radiological technology have been associated with an ever-increasing complexity, and so keeping up with terminology, understanding the significance of basic radiological signs, and appreciating the prognostic impact of findings on imaging tests, is not an easy undertaking for the physician. Until now, there has been a lack of practical, pocket-sized, but authoritative texts dealing principally with the imaging features of pulmonary disease. Covering the essential elements of pulmonary imaging in a concise and digestible format, Thoracic Imaging deals with both the key principles of thoracic imaging, including a separate section on the common radiological terms used to describe pulmonary pathology, and the principal pathological compartments that are affected in specific disease processes. It is packed with over 600 high quality illustrations to highlight the important radiological features in the different diseases, with an emphasis on chest radiography (CXR) and computed tomography (CT) to mirror routine clinical practice.

Paediatric Respiratory Medicine Second edition remains the first point of reference for those faced with treating acute or chronic respiratory problems. The handbook discusses the approach to clinical problems, specific conditions, supportive care and practical procedures, and includes vital appendices covering specific tests and statistics. Designed as a practical guide, it serves general and specialist paediatricians at both consultant and trainee level. The book is divided into five parts. Part I provides a practical approach to acute and non-acute clinical problems. Part II provides detailed information about common and more rare clinical conditions. Part III provides useful information on supportive care, including for example, use of non-invasive ventilation and the care of a child with a tracheotomy. Part IV gives details on how to perform several practical procedures, such as ciliary brush biopsy, flexible bronchoscopy, and inserting a chest drain. The appendices provide information on lung function testing and tables of age-corrected normal values for several respiratory parameters. Written by three consultants in paediatric respiratory medicine, their expertise in the subject provides all levels of paediatricians with practical guide on a subject that is increasingly relevant in paediatrics.

This book provides a comprehensive overview of how to use MRI for the imaging of lung disease. Special emphasis is placed on routine applications and the clinical impact of MRI in each setting. In addition, current technological developments are reviewed and information presented on dedicated applications of MRI in preclinical and translational research, clinical trials, and specialized institutions. During the past two decades, significant advances in the technology have enabled MRI to enter and mature in the clinical arena of chest imaging. Standard protocols are now readily available on MR scanners, and MRI is recommended as the first- or second-line imaging modality for a variety of lung diseases, not limited to cystic fibrosis, pulmonary hypertension, and lung cancer. The benefits and added value of MRI originate from its ability to both visualize lung structure and provide information on different aspects of lung function, such as perfusion, respiratory motion, ventilation, and gas exchange. On this basis, novel quantitative surrogates for lung function and therapy control (imaging biomarkers) are generated. The second edition of MRI of the Lung has been fully updated to take account of recent advances. It is written by an internationally balanced team of renowned authors representing all major groups in the field.

This book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation

Mechanical ventilation is an essential life-sustaining therapy for many critically-ill patients. As technology has evolved, clinicians have been presented with an increasing number of ventilator options as well as an ever-expanding and confusing list of terms, abbreviations, and acronyms. Unfortunately, this has made it extremely difficult for clinicians at all levels of training to truly understand mechanical ventilation and to optimally manage patients with respiratory failure. Mechanical Ventilation was written to address these problems. This handbook provides students, residents, fellows, and practicing physicians with a clear explanation of essential physiology, terms and acronyms, and ventilator modes and breath types. It describes how mechanical ventilators work and explains clearly and concisely how to write ventilator orders, how to manage patients with many different causes of respiratory failure, how to "wean" patients from the ventilator, and much more. Mechanical Ventilation is meant to be carried and used at the bedside and to allow everyone who cares for critically-ill patients to master this essential therapy.

Concise yet comprehensive, this textbook of clinical pulmonology provides pulmonologists and respiratory disease physicians with all the key information that they need to know to manage the patient through the diagnosis and treatment journeys. From the most common condition to the rarest, each disease is consistently presented and comprehensively covered giving the reader just the key facts. Building upon the basic sciences and integrating these with clinical practice, each chapter has a consistent approach, is highly designed and visually appealing. Numerous illustrations, colour photographs, scans, bullet points, tables and algorithms ensure that the key information is available at a glance. The keynote sections serve as a useful revision aid as do the multiple choice questions. With an integrated E book, many more illustrations, video clips and further helpful links and resources on line, the book has an integrated multimedia approach. A truly international and highly experienced editorship with expert contributors from around the world ensure that the book remains a trusted source of information* Concise yet thorough coverage ensures that the book is comprehensive in its approach* Each chapter is very consistent, synoptic and gives the key facts at a glance* Highly designed, well illustrated and visually appealling with numerous illustrations, boxes, red flags and clinical pearls* Truly international expert editors and contributors ensure that the book is a trusted source of information written by highly experienced teachers and clinicians* An integrated E book with many more illustrations, video clips and further resources on lineSet at the level between the definitive reference work and the clinical manual, Keynotes in Clinical Pulmonology is an invaluable cornerstone for all pulmonologists whether trainees or experienced clinicians.

Chest Imaging presents a comprehensive review of thoracic pathologies commonly encountered by practicing radiologists and residents in training. The volume covers topics including: Common Abnormalities, Emergency Radiology, Pleural Disease, Infections, Neoplasms, and Airway Disease. Each section begins with an overview chapter that orientes the reader to the concerns and issues related to imaging in the specific anatomic region or category. Part of the Rotations in Radiology series, this book offers a guided approach to imaging diagnosis with examples of all imaging modalities complimented by the basics of interpretation and technique and the nuances necessary to arrive at the best diagnosis. Each chapter contains a targeted discussion of a pathology which reviews the definition, clinical features, anatomy and physiology, imaging techniques, differential diagnosis, clinical issues, key points, and further reading. This book is a must-read for residents and practitioners in radiology seeking refreshing on essential facts and imaging abnormalities in thoracic imaging.

Mit dem Band III "Die Staublungenerkrankungen" werden samtliche Vortrage und Diskussionen der 3. internationalen Staublungentagung vorgelegt, die vom 29. bis 31. Oktober 1957 in Munster stattfand. Der Inhalt vermittelt nicht nur einen guten UEberblick uber den Stand der Forschung, sondern zeigt auch die Ansatzpunkte fur die weiteren Auf gaben und lasst im Vergleich mit Band I (1950) und Band II (1954)" deut lich erkennen, welche beachtlichen Fortschritte erzielt worden sind. Wie 1949 und 1953 so ist auch dieser Kongress der Initiative von Professor KARL-WILHELM J OETTEN t zu verdanken. Ihm war der inter nationale Austausch von Ergebnissen und Erfahrungen auf dem so kom plexen Gebiete der Staublungenforschung ein besonderes Anliegen. Es ist daher gewiss gerechtfertigt, in diesem Bericht seiner dankbar zu gedenken. Zum Abschluss der Tagung hat K. W. JOETTEN der Hoffnung Ausdruck gegeben, dass man sich in 4 Jahren in Munster wieder versammeln durfe. Im engen Kreise jedoch hegte er fur seine Person Zweifel, wohl wissend, dass jenseits des 70. Lebensjahres die Jahre kostbar werden und Ge schenke sind. Nun ist er am 13. Mai 1958 nach kurzer Krankheit gestor ben. Mit ihm ist eine gepragte, kraftvolle Persoenlichkeit, ein erfolgreicher Forscher und begeisterter Hochschullehrer dahingegangen. Sein Tod hinterlasst eine Lucke, die kaum zu schliessen sein wird.

From principles of oxygen delivery and patient assessment, through rapid sequence induction of anaesthesia and tracheal intubation, to the difficult and failed emergency airway, this book from an expert team of clinicians guides the reader through every aspect of emergency airway management. Retaining the concise, accessible format of the first edition, it includes a new section on human factors and improving teamwork and performance, an expanded special circumstances section, and a summary of the 4th National Audit Project of the Royal College of Anaesthetists and Difficult Airway Society and its implications for practice. Updated guidelines, new technologies such as videolaryngoscopy, and recent evidence have all been incorporated into the chapter content, ensuring that the book reflects best current practice. This thoroughly updated new edition remains an essential resource for navigating a highly challenging clinical scenario and will be of value to emergency medicine, intensive care, anaesthesia and acute medicine clinicians.

Guide to Targeted Therapies: EGFR Mutations in NSCLC is a speedy and up-to-date review, which discusses EGFR mutations, testing methods and technology, current and emerging therapies, and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of EGFR gene mutations as well as a summary of current therapies will benefit from this succinct guide.

Questo libro riporta lo stato dell'arte delle piu comuni malattie dell'apparato respiratorio. La prima parte e dedicata all'anatomia del polmone, alla regolazione della respirazione e alla meccanica respiratoria, seguita dall'esame funzionale del paziente respiratorio e dalla diagnostica invasiva e non invasiva, inclusa la diagnostica per immagini in pneumologia. Nella descrizione delle malattie particolare importanza e stata data nel chiarire il "perche" dei diversi sintomi e segni clinici mentre l'approccio terapeutico, confrontato con le linee guida internazionali, fa comunque riferimento alla vasta esperienza clinica degli autori. L'obiettivo principale di questo libro e quindi quello di riportare le piu recenti acquisizioni nella fisiologia, fisiopatologia e clinica delle malattie dell'apparato respiratorio, inclusa la ventilazione meccanica non invasiva, l'ossigenoterapia e la riabilitazione respiratoria, e di combinare una chiara descrizione della fisiopatologia respiratoria con enfasi alla sua applicazione clinica. Il volume e rivolto sia agli studenti del corso di laurea specialistica in medicina e chirurgia, sia agli specializzandi in malattie dell'apparato respiratorio. Rappresenta inoltre un valido riferimento per il medico di medicina generale, soprattutto quando quest'ultimo intenda aumentare le proprie conoscenze cliniche, diagnostiche e terapeutiche nel settore delle patologie respiratorie, branca che sempre piu frequentemente coinvolge il medico e lo specialista nella risoluzione di casi anche molto complessi.

Originally published in 1917, as part of the Cambridge Public Health Series, this book was written to provide a guide for those 'interested in the stamping out of tuberculosis'. The text approaches the disease from an outlook based around experimental pathology, avoiding the clinical perspective already well represented in previous works by other researchers. Numerous illustrative figures and an appendices section are also included. This book will be of value to anyone with an interest in public health, the history of medicine and the historical understanding of tuberculosis.

Pneumonia (along with influenza) is the sixth leading cause of death in adults. About 4 million adults develop pneumonia each year in the US, resulting in 64 million days of restricted activity, 39 million days of bed confinement, and 10 million days of lost work. Yet the admission rates to hospital, length of stay, investigations, antimicrobial therapy and prevention strategies vary greatly from one geographic area to the next, and the scientific basis for many of our management strategies for pneumonia is weak to nonexistent. There are over 100 microbial agents that can cause pneumonia and many of these, especially Streptococcus pneumoniae, Group A streptococcus, and Staphylococcus aureus, are in a state of flux in terms of changing antimicrobial resistance. This book is designed to provide new information about pneumonia and identify critical research questions that will come to the fore as we enter the 21st century.

This book offers a state-of-the-art description of the complexity of the healthy and pathological respiratory system, with particular reference to the mechanics of the airways, lung and chest wall. Detailed information is provided on new insights into the mechanics of breathing that have been obtained through technological innovations in measurement systems, cutting-edge modeling techniques and novel approaches to functional imaging of the respiratory system. It is explained how these advances permit the assessment of emerging treatment approaches, including new drugs, innovative surgical techniques and modes of mechanical ventilation and new forms of rehabilitation. In order to ensure comprehensive coverage of the subject, the editor has assembled a multidisciplinary team of authors comprising basic scientists in respiratory medicine, chest and intensive care physicians and bioengineers involved in both modeling and instrumentation. The book is intended for intensive care physicians, respirologists, physiologists, rehabilitation specialists, basic scientists in respiration, research and clinical fellows, biomedical engineers involved with respiratory mechanics and respiratory therapists. They will update their knowledge and improve their clinical expertise.

"The best of all pulmonary function tests is the operation itself." Bjoerkman 1953 Noch vor drei Jahrzehnten liess sich die Situation der Funktionsdiagnostik mit einem solchen Satz treffend darstellen. Mit dem immer haufiger auftretenden Bronchial- karzinom und dem damit verbundenen Anstieg lungenchirurgischer Eingriffe ge- wann jedoch die praoperative Funktionsdiagnostik einen voellig neuen Stellenwert. Ihre Aufgabe in der chirurgischen und endoskopischen Pneumologie ist es, Risiko- patienten zu identifizieren und sie einer speziellen praoperativen Therapie, einer moeglichst schonenden Anasthesie, selektiver Chirurgie und gezielter Nachsorge zu- zufuhren. Die pulmonale Funktionsdiagnostik wurde von der schnellen Entwicklung der Mess- technik erheblich beeinflusst. Anfangs war sie durch einen grossen Investitions-und Bedienungsaufwand belastet, heute gilt es jedoch Loesungswege aufzuzeigen, die zur Entwicklung einfacher und schneller Verfahren fuhren - Verfahren, die eine exakte funktionelle Beurteilung und besonders bettseitige Anwendung gestatten. Damit sollte auch eine differenzierte Diagnostik der fruhen postoperativen oder postendo- skopischen Phase moeglich sein. Die in Frage kommenden Methoden mussen folgende Bedingungen erfullen: Sie sollen einfache interpretierbare Messwerte liefern, kostengunstig, uberall durchfuhr- bar, genugend empfindlich, gut reproduzierbar und vergleichbar sein. Wir haben uns deshalb in diesem Buch die Aufgabe gestellt, die verfugbaren Verfahren auf ihre Brauchbarkeit zur Quantifizierung der pulmonalen Insuffizienz zu prufen und eine Wertung zu erarbeiten.

Die Zytologie von Lunge und Pleura ist eine morphologisch vielfaltige und anspruchsvolle Untersuchungsmethode, die nur durch die Zusammenarbeit zwischen Klinikern, Radiologen, Labormedizinern und Zytologen eine prazise Diagnostik ermoeglicht. Dieses Buch ermoeglicht einen schnellen und detaillierten Zugang zur Information uber Lungen- und Pleuraerkrankungen. Der Materialgewinnung, mit Schwerpunkt endoskopischer Untersuchungsmethoden, und der Materialverarbeitung, inklusive Immunzytochemie und Flowzytometrie, sind eigene Kapitel gewidmet. Anschliessend werden benigne und maligne Erkrankungen mit Definition, Epidemiologie/AEtiologie sowie Klinik und Zytologie ausfuhrlich beschrieben. Zytologische Charakteristika sind fur eine schnelle Information durch die Hervorhebung in Bloecken gut ersichtlich und im Bildteil mit uber 200 farbigen Abbildungen belegt. Die Klinische Zytologie der Lunge und Pleura ist fur den in Ausbildung stehenden Zytologen ein Lehrbuch und fur den klinisch Tatigen ein ubersichtliches Nachschlagewerk fur die tagliche Praxis. Fur alle Kliniker ist dieses Buch ein nutzlicher Ratgeber in diagnostischen Fragestellungen der Pulmologie.

Auf der Jahresversammlung der Schweizerischen Gesellschaft fur Intensivmedizin im November 1977 in Regensdorf/Zurich wurde als eines der Hauptthemen die sog. "Schocklunge" eingehend behandelt. Dieser Anlass hatte zur Bildung einer Arbeitsgruppe aus namhaften intensivmedizinischen Zentren der Schweiz gefuhrt und gab sozusagen den Startschuss, den Problemen des "adult respiratory distress syndrome" (ARDS) auf breiterer Basis nachzugehen. Der vorliegende Sammelband prasentiert nun unter der Koordination der drei Herausgeber das heutige Wissen uber dieses doch oft recht geheimnisvolle Krankheitsbild. Die Schweizerische Gesellschaft fur Intensivmedizin ist stolz, dass dieses Werk entstehen konnte, und wunscht ihm die Beachtung und Verbreitung, die es ihrer Ansicht nach verdient. Zurich, Januar 1980 P. FREY Prasident der Schweizerischen Gesellschaft fur Intensivmedizin Inhalt 1 ARDS: Ein klinisches Syndrom - eine morphologische Einheit 1 R. KELLER, G. WOLFF und P. M. SUTER. . . . . . . . . . . 2 Die Klinik des ARDS E. RUBLI und F. ROTH (Mit 6 Abb.) 3 Klinische Symptome . . . . . 4 Mitbeteiligung anderer Organe. 13 Verlauf und Prognose 17 Literatur . . . . . . . . . . 17 3 Pathologie 3.1 Die morphologischen Veranderungen beim ARDS M. BACHOFEN, H. BACHOFEN und F. ROTH (Mit 7 Abb.) . 19 28 Literatur . . . . . . . . . . . . . . . . . . . . ."

In diesem Buch werden neben Spezialkapiteln ausf}hrlich Themen behandelt, die insbesondere den niedergelassenen Arzt interessieren. Jedes klinische Kapitel enth{lt ausf}hrliche Therapieempfehlungen. Zahlreiche Tabellen und Schemata erleichtern eine rasche und vollst{ndige Orientierung. Das Buchist sowohl ein praktischer Leitfaden f}r Diagnose, Differentialdiagnose und Therapie als auch ein Nachschlagewerk, das }ber seltene Erkrankungen und }ber spezielle Techniken umfassend Auskunft gibt.

Bronchialkarzinome stellen in den westlichen Industrienationen die haufigste Malignomform des Mannes dar und werden auch bei Frauen zunehmend oefters beobachtet. Wahrend die Therapiebemuhungen zu- nachst auf die lokalen chirurgischen und radiologischen Massnahmen beschrankt bleiben mussten, gewann seit Ende der 60iger Jahre die Chemotherapie bei den kleinzelligen, spater in geringerem Masse auch bei den nichtkleinzelligen Bronchialkarzinomen an Bedeutung. Dabei wurden zahlreiche, zum Teil auch divergierende Ergebnisse erhoben, die einen intensiven Meinungs-und Erfahrungsaustausch sinnvoll erschei- nen liessen. Dazu trafen sich im September 1984 onkologisch tatige AErzte aus Deutschland und dem deutschsprachigen Ausland in Frankfurt. Nach Grundsatzreferaten zur Bestimmung der Therapiesituation bei klein- zelligen und nichtkleinzelligen Bronchialkarzinomen blieb genugend Zeit fur Beitrage zu Einzelaspekten sowie zu einer ausgedehnten Dis- kussion. Neue Therapieansatze konnten aufgezeigt und Kooperationen aktiviert werden. Zum Gelingen der Tagung trug besonders das Engage- ment der Teilnehmer, aber auch die hervorragende Organisation von Herrn D. Preding (Eli Lilly GmbH, Deutschland) bei. Es bleibt bei dem zunehmenden und fur den einzelnen kaum noch uberschaubaren Informationsangebot zu hoffen, dass dieser intensive und informative Meinungsaustausch in den geplanten regelmassigen Abstanden wiederholt werden kann. April 1985 N. NIEDERLE S.SEEBER Inhaltsverzeichnis Ergebnisse und Moeglichkeiten der Behandlung beim kleinzelligen Bronchialkarzinom N. NIEDERLE (Mit 7 Abbildungen). . . . . . . . . . .. . . 1 Strahlentherapeutische Aspekte beim kleinzelligen Bronchus-Carcinom H.-P. HEILMANN . . . . . . . . . . . . . . . . . 35 . . . . Die Rolle der Strahlentherapie in der Behandlung des kleinzelligen Bronchialkarzinoms W. ALBERTI . . . . . . . . . . . . . . . . .. . . . 37 .

Generalisierte Lungenparenchymerkrankungen, frtiher auch interstitielle Lungener- krankungen genannt, stellen eine atiologisch sehr unterschiedliche Krankheitsgruppe dar: Zu ihnen zahlen durch Inhalation anorganischer und organischer Staube bedingte Erkrankungen wie Asbestose oder allergische Alveolitis ebenso wie infektios und me- dikamenWs hervorgerufene Lungenparenchymschaden wie etwa die Pneumocystis-ca- rinii-Pneumonie oder die Bleomycinlunge, Ein Gutteil der generalisierten Lungenparen- chymerkrankungen ist atiologtsch nicht geklart, nosologisch aber sehr gut definiert, wie etwa die idiopathische Lungenfibrose, die Sarkoidose oder Lungenbeteiligung im Rah- men von Systemerkrankungen wie die Histiozytosis X oder die Lymphangioleiomyo- matose, Pathophysiologisch dagegen manifestieren sich generalisierte Lungenparenchymer- krankungen ziemlich stereotyp: Lungenstarre, meBbar an einer Reduktion der Lungen- compliance und der Reduktion der statischen Volumina im Sinne der Restriktion sowie DiffusionsstOrung, meBbar an einer Erniedrigung der Diffusionskapazitat und einem Abfall des arteriellen Sauerstoffpartialdruckes unter Belastung, sind bei allen generali- sierten Lungenparenchymerkrankungen mit unterschiedlichen Akzenten zu finden, Da die Klinik mit unproduktivem Husten und Belastungsdyspnoe und die Rontgen- veranderungen uncharakteristisch sind, ist bei jedem Patienten der Kliniker immer wieder neu gefordert.