This issue will focus on treatments for Chronic Rhinosinusitis. Dr. Wyste Fokkens guest edits topics such as: "Inflammatory mechanisms in chronic rhinosinusitis with or without nasal polyposis," "European versus Asian Chronic rhinosinusitis. What did it teach us and what do we want to know," "Epithelium, cilia and mucus, their importance in chronic rhinosinusitis Noam Cohen Noam," "Aspirin intolerance: does desensitization alter the course of the disease," "Anti-inflammatory effects of macrolides: applications in CRS," and more!

Topics include: The History of Polysomnography and Sleep Technology, Generating a Signal: Biopotentials, Amplifiers and Filters, Recording sleep; Electrodes, 10/20 Recording system and sleep system specifications, Staging sleep, Respiratory monitoring equipment and detection of respiratory events, Differentiating Nocturnal Movements; Leg movements, Parasomnias and Seizures, Cardiac monitoring during sleep, Determination of Sleepiness - MWT & MSLT, Pediatric Polysomnography, PSG features of medical and psychiatric disorders and their treatments, Artifacts and Troubleshooting, Portable Monitoring, PAP titration, The Future of Sleep and Circadian Testing

This issue of Clinics in Laboratory Medicine, entitled Respiratory Viruses in Pediatric and adult Populations, is Guest Edited by Alexander J. McAdam MD, PhD, and includes: Developments in Specimen Collection and Tissue Culture for Respiratory Viruses; Nucleic acid amplification assays for respiratory viruses; Emerging molecular assays for respiratory viruses; Drug Resistance in Influenza Virus; Quantitative assays for adenovirus; RSV vaccine development; Human Metapneumovirus; and Recently discovered coronaviruses.

This book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation

Topics include: The Obesity Epidemic, Altered Resting and Exercise Respiratory Physiology in Obesity, Association of Asthma and Other Obstructive Lung Diseases and Obesity, Role of Obesity in Obstructive Sleep Apnea, The Pickwickian Syndrome - Obesity Hypoventilation Syndrome, Obesity and Thromboembolic Disease, Medical Therapy of Obesity, Obesity and Bariatric Surgery, Airway Management of Patients with Obesity, Anesthetic Management of Patients with Obesity, Obesity and Acute Lung Injury, Obese Patients in the Intensive Care Units, Obesity Cardiomyopathy, Obesity and Respiratory Diseases in Childhood, Obesity and Respiratory Diseases in the Aging Population.

This issue provides an update on some of the most common conditions that a pulmonologist sees in the ICU. Topics covered include intraabdominal hypertension, liver failure, intracranial catastrophes, critical issues in Nephrology, Heart failure, adrenal insufficiency and septic shock, obstetrical emergencies in critical care, hematologic issues in the ICU, ICU cognitive outcomes, end-of-life issues, sepsis, sedation and analgesia, measurement of quality and assurance of safety, and critical care of the hematopoetic transplant recipient.

In this imporatant update, the guest editors have brought together experts in fungal disease to discuss some of the most important topics in this area: histoplasmosis, blastomycosis, coccidioidomycosis, PCP, cryptococcosis, fungal infections in the era of biologics, Candida in the ICU, Aspergillus pulmonary syndromes, fungal disease in BMT and SOT, fungal complications of lung transplantation, Moulds, serology and Ag testing, role of BAL in rapid diagnosis, molecular testing, and overview of antifungal agents.

In the era of evidence-based medicine, clinicians draw upon a vast resource of research-based evidence to guide their practice. However, finding this information is not always easy, particularly when it is most needed. In the case of respiratory medicine which covers more than 40 individual conditions, the research-based evidence may be limited and/or disproportionate to the incidence of the condition. Guidelines are available but difficult and time consuming to find.
This book is designed to overcome this problem. Many of the key recommendations to be found in current evidence-based guidelines are presented in a uniform and accessible format. The same format has been used for expert opinion on best practice where the evidence base is limited. The design of this book makes locating the information needed both quick and simple, and the succinct yet easy-to-read nature of the text means that key points can be reviewed and assimilated rapidly. The text is enhanced by a number of summary boxes and tables for quick reference to the key points covered in the narrative. A large number of these sections also have radiological images illustrating the relevant abnormalities. Written by experts in their field, this book presents a succinct overview based on both best practice and available research evidence.

This issue of Pediatric Clinics, guest edited by Dr. Anne Chang, reviews the topic of Common Respiratory Disorders of Childhood. The articles in this issue approach the topic from an evidence-based management perspective. The first half of the issue offers symptom-based articles addressing respiratory noises, cough, exercise intolerance/dyspnoea, chest pain and chest wall deformity, and recurrent upper and lower respiratory infections. The second half of the issue offers disease-based articles on topics including upper respiratory tract infections and ear infections, asthma, bronchiolitis and croup, congenital airway lesions and lung disease, bronchiectasis and cystic fibrosis, aspiration lung disease, pneumonia and other respiratory infections, sleep disorders, neuromuscular disease and other chronic respiratory failure, and children on ambulatory oxygen.

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.
* Each chapter considers Asthma and COPD in side-by-side contrast and comparison not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management
* Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD
* Most extensive reference to primary literature on both Asthma and COPD in one source.
* Easy-to-read summaries of the latest advances alongside clear illustrations

Cystic Fibrosis: The Facts provides a much needed simple and understandable source book about this disease. It is aimed at those living with Cystic Fibrosis (CF), either themselves or members of their families or their friends.
The book explains clearly what is happening to the body in CF, what causes it and what treatment options are available for the different aspects of the disease. There are more detailed chapters for those wanting to find out about the genetics of the disease and specific aspects such as how it affects life choices and employment. It looks to the future in terms of potential new therapies for CF and provides useful information on organizations that can provide help and further information across those areas of the world where the disease is prevalent.

Respiratory syncytial virus (RSV) was first identified half a century ago in 1956. Following its discovery, the virus soon became recognised as a major viral pathogen causing extensive outbreaks of respiratory tract infections in both the very young and in vulnerable adults. It is an unusual virus in that it can cause repeated reinfections throughout life. The topics covered within this volume are wide ranging in scope from the most basic molecular biology of the virus to the clinical picture of RSV in the developing world. The internationally recognised experts were invited not only to review the present state of knowledge but also to give their perspective on the current situation and to identify the gaps and future requirements for research in an effort to stimulate new cross-cutting approaches to tackle this major viral pathogen.

This book comprehensively presents all the necessary information health professionals need to become Certified Asthma Educators. Competent asthma educators must possess a number of skills: they must have appropriate and sound medical and pharmaceutical knowledge; be proficient and effective educators who can influence their patients' behaviors for the better; and, finally, they need the administrative and organizational skills needed to set up and run efficient clinics at their places of work. The book is divided into three sections to meet those needs: Asthma: The Fundamentals; The Role of Education; and, The Effective Asthma Educator. The first section covers clinical knowledge of asthma, with chapters including lung structure and function, clinical presentation of asthma, and environmental issues in asthma management. The second section delves into the role of educating patients and teaches readers how to best do that with an integrated approach between physician, educator, and patient. The third section looks further into educating techniques with a view of the learning process, considerations for instruction locations, and the role the educator plays overall. The final chapter in the book presents example cases for readers to assess the knowledge they have learned throughout. This second edition serves as both textbook and study guide for certification as well as a long-term reference publication. It has been fully updated from the previous edition with the latest treatment guidelines, medications, and disease monitoring methods. This is an ideal guide for asthma educators, those seeking NAECB certification, and any health professional involved with individuals who have asthma.

The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918. Previous to this, a novel coronavirus had been identified as the aetiological agent of the severe acute respiratory syndrome (SARS), a new respiratory viral disease that emerged at the end of 2002 and caused profound disturbances in over 30 countries worldwide in 2003. It is not known whether the SARS coronavirus will re-emerge, especially since its origins and potential reservoir(s) are unresolved. However, these outbreaks have shown that these viruses can emerge in any part of the world at any time.

This book critically evaluates the latest scientific evidence on novel or re-emerging viral diseases and brings together contributions from world experts on this topic, explaining best practice in their area, and discussing lessons learned and how best to collaborate to prevent and control future outbreaks.

Topics covered include: the latest advances in virology, particularly in the area of epidemiology diagnostics animal models for viral infection, and antiviral and vaccine development.

"Novel and Re-emerging Respiratory Viral Diseases" offers a comprehensive and interdisciplinary account of all aspects of the topic, from basic molecular biology to public health issues, and is therefore essential reading for virologists, infectious disease specialists, public health managers, researchers and epidemiologists, as well as those working invaccine development, pharmaceutical medicine and drug discovery

Questo libro riporta lo stato dell'arte delle piu comuni malattie dell'apparato respiratorio. La prima parte e dedicata all'anatomia del polmone, alla regolazione della respirazione e alla meccanica respiratoria, seguita dall'esame funzionale del paziente respiratorio e dalla diagnostica invasiva e non invasiva, inclusa la diagnostica per immagini in pneumologia. Nella descrizione delle malattie particolare importanza e stata data nel chiarire il "perche" dei diversi sintomi e segni clinici mentre l'approccio terapeutico, confrontato con le linee guida internazionali, fa comunque riferimento alla vasta esperienza clinica degli autori. L'obiettivo principale di questo libro e quindi quello di riportare le piu recenti acquisizioni nella fisiologia, fisiopatologia e clinica delle malattie dell'apparato respiratorio, inclusa la ventilazione meccanica non invasiva, l'ossigenoterapia e la riabilitazione respiratoria, e di combinare una chiara descrizione della fisiopatologia respiratoria con enfasi alla sua applicazione clinica. Il volume e rivolto sia agli studenti del corso di laurea specialistica in medicina e chirurgia, sia agli specializzandi in malattie dell'apparato respiratorio. Rappresenta inoltre un valido riferimento per il medico di medicina generale, soprattutto quando quest'ultimo intenda aumentare le proprie conoscenze cliniche, diagnostiche e terapeutiche nel settore delle patologie respiratorie, branca che sempre piu frequentemente coinvolge il medico e lo specialista nella risoluzione di casi anche molto complessi.

Focusing on assessment through therapist-driven protocols, this valuable tool provides an overview of the assessment process and fundamentals needed for success. It offers discussion of the top five treatment protocols: oxygen, hyperinflation , bronchial hygiene and bronchodilator therapies, as well as mechanical ventilation. Using a case study approach, students learn to manage an entire case from beginning to end. Each time they assess the patient, they use the SOAP format: Subjective, Objective, Assessment, and Plan reasoning, giving them practice in documenting history and developing care plans.

Mit dem Band III "Die Staublungenerkrankungen" werden samtliche Vortrage und Diskussionen der 3. internationalen Staublungentagung vorgelegt, die vom 29. bis 31. Oktober 1957 in Munster stattfand. Der Inhalt vermittelt nicht nur einen guten UEberblick uber den Stand der Forschung, sondern zeigt auch die Ansatzpunkte fur die weiteren Auf gaben und lasst im Vergleich mit Band I (1950) und Band II (1954)" deut lich erkennen, welche beachtlichen Fortschritte erzielt worden sind. Wie 1949 und 1953 so ist auch dieser Kongress der Initiative von Professor KARL-WILHELM J OETTEN t zu verdanken. Ihm war der inter nationale Austausch von Ergebnissen und Erfahrungen auf dem so kom plexen Gebiete der Staublungenforschung ein besonderes Anliegen. Es ist daher gewiss gerechtfertigt, in diesem Bericht seiner dankbar zu gedenken. Zum Abschluss der Tagung hat K. W. JOETTEN der Hoffnung Ausdruck gegeben, dass man sich in 4 Jahren in Munster wieder versammeln durfe. Im engen Kreise jedoch hegte er fur seine Person Zweifel, wohl wissend, dass jenseits des 70. Lebensjahres die Jahre kostbar werden und Ge schenke sind. Nun ist er am 13. Mai 1958 nach kurzer Krankheit gestor ben. Mit ihm ist eine gepragte, kraftvolle Persoenlichkeit, ein erfolgreicher Forscher und begeisterter Hochschullehrer dahingegangen. Sein Tod hinterlasst eine Lucke, die kaum zu schliessen sein wird.

Guide to Targeted Therapies: EGFR Mutations in NSCLC is a speedy and up-to-date review, which discusses EGFR mutations, testing methods and technology, current and emerging therapies, and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of EGFR gene mutations as well as a summary of current therapies will benefit from this succinct guide.

This unique manual provides comprehensive, yet practical and easily accessed advice on the key issues of asthma management in both adult andpaediatric patients. The second edition will continue to help all those involved with the care of asthmatic patients to apply the recently updated international guidelines. It combines vital information on how to tackle practical, clinical issues, whilstat the same time highlighting essential basic sciences to aid diagnosis, management and treatment.Provides solutions to day-to-day clinical problems in asthma management Clear, concise and practical advice helps the reader to clarify asthma severity and select appropriate treatment plansDiagrams illustrate the stepwise approaches to asthma management Each chapter concludes with a list of summary pointsExpanded sections on acute and chronic asthma in children written by international paediatric respiratory experts Use of icons in margins to highlight the most recent drugs and therapiesNew larger format, with an eye-catching design aids easy access to key information

Shortness of Breathis a user-friendly patient handbook for those suffering from chronic lung disease. The authors successfully present a large amount of complex information in a manner that the average reader can understand. It gives invaluable information on dealing with the psychological as well as the physical impacts of lung disease including suggestions for exercise programmes, relaxation tips, travel precautions, diet, etc. Clever cartoons are used to illustrate key points and many topics are addressed in a question and answer format. A well-written book which conveys that the quality of life does not have to be severely hampered by lung disease.Affordable for patients Small and easy for patients to carry roundContains the latest information

"The best of all pulmonary function tests is the operation itself." Bjoerkman 1953 Noch vor drei Jahrzehnten liess sich die Situation der Funktionsdiagnostik mit einem solchen Satz treffend darstellen. Mit dem immer haufiger auftretenden Bronchial- karzinom und dem damit verbundenen Anstieg lungenchirurgischer Eingriffe ge- wann jedoch die praoperative Funktionsdiagnostik einen voellig neuen Stellenwert. Ihre Aufgabe in der chirurgischen und endoskopischen Pneumologie ist es, Risiko- patienten zu identifizieren und sie einer speziellen praoperativen Therapie, einer moeglichst schonenden Anasthesie, selektiver Chirurgie und gezielter Nachsorge zu- zufuhren. Die pulmonale Funktionsdiagnostik wurde von der schnellen Entwicklung der Mess- technik erheblich beeinflusst. Anfangs war sie durch einen grossen Investitions-und Bedienungsaufwand belastet, heute gilt es jedoch Loesungswege aufzuzeigen, die zur Entwicklung einfacher und schneller Verfahren fuhren - Verfahren, die eine exakte funktionelle Beurteilung und besonders bettseitige Anwendung gestatten. Damit sollte auch eine differenzierte Diagnostik der fruhen postoperativen oder postendo- skopischen Phase moeglich sein. Die in Frage kommenden Methoden mussen folgende Bedingungen erfullen: Sie sollen einfache interpretierbare Messwerte liefern, kostengunstig, uberall durchfuhr- bar, genugend empfindlich, gut reproduzierbar und vergleichbar sein. Wir haben uns deshalb in diesem Buch die Aufgabe gestellt, die verfugbaren Verfahren auf ihre Brauchbarkeit zur Quantifizierung der pulmonalen Insuffizienz zu prufen und eine Wertung zu erarbeiten.

This book offers a state-of-the-art description of the complexity of the healthy and pathological respiratory system, with particular reference to the mechanics of the airways, lung and chest wall. Detailed information is provided on new insights into the mechanics of breathing that have been obtained through technological innovations in measurement systems, cutting-edge modeling techniques and novel approaches to functional imaging of the respiratory system. It is explained how these advances permit the assessment of emerging treatment approaches, including new drugs, innovative surgical techniques and modes of mechanical ventilation and new forms of rehabilitation. In order to ensure comprehensive coverage of the subject, the editor has assembled a multidisciplinary team of authors comprising basic scientists in respiratory medicine, chest and intensive care physicians and bioengineers involved in both modeling and instrumentation. The book is intended for intensive care physicians, respirologists, physiologists, rehabilitation specialists, basic scientists in respiration, research and clinical fellows, biomedical engineers involved with respiratory mechanics and respiratory therapists. They will update their knowledge and improve their clinical expertise.

Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become "the" reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field.
Key Features
* Comprehensive coverage of both basic science and clinical aspects of asthma
* Extensively referenced throughout

Pneumonia (along with influenza) is the sixth leading cause of death in adults. About 4 million adults develop pneumonia each year in the US, resulting in 64 million days of restricted activity, 39 million days of bed confinement, and 10 million days of lost work. Yet the admission rates to hospital, length of stay, investigations, antimicrobial therapy and prevention strategies vary greatly from one geographic area to the next, and the scientific basis for many of our management strategies for pneumonia is weak to nonexistent. There are over 100 microbial agents that can cause pneumonia and many of these, especially Streptococcus pneumoniae, Group A streptococcus, and Staphylococcus aureus, are in a state of flux in terms of changing antimicrobial resistance. This book is designed to provide new information about pneumonia and identify critical research questions that will come to the fore as we enter the 21st century.

Lung Transplantation: Principles and Practice covers the current practice in donor and recipient management as well as current treatment strategies and outcomes. With 39 chapters from international experts in the field, the book is divided into four broad sections: General Topics, Donor Management, Recipient Management and Outcome, and the Future of Lung Transplantation. The book discusses significant advances achieved in the past decade in areas such as donor allocation, organ preservation and management, recipient selection, management and support, surgical and critical care techniques, immune suppression, and infection prophylaxis. Specific instances of pulmonary disease that commonly necessitate lung transplantation are also covered. Generously illustrated in full color, this valuable resource is relevant to both specialists and other providers who may refer or care for patients before and after transplantation.