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Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
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Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors (Paperback, 2012)
Loot Price: R2,751
Discovery Miles 27 510
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Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors (Paperback, 2012)
Series: Advances in Anatomy, Embryology and Cell Biology, 211
Expected to ship within 10 - 15 working days
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Airway sensory nerve terminals are tailored to detect changes in
the physical and chemical environment, thereby supplying local
pulmonary information to the central nervous system. Since most
intrapulmonary nerve terminals arise from fibres travelling in the
vagal nerve, the classification of sensory airway receptors' is
largely based on their action potential characteristics,
electrophysiologically registered from the vagal nerve. However,
the architecture of airways and lungs makes it nearly impossible to
functionally locate the exact nerve terminals that are responsible
for the transduction of a particular intrapulmonary stimulus. In
this monograph we focus on three sensory receptor end organs in
lungs that are currently morphologically well-characterised: smooth
muscle-associated airway receptors (SMARs), neuroepithelial bodies
(NEBs) and visceral pleura receptors (VPRs). Unravelling the main
functional morphological and neurochemical characteristics of these
sensory receptors using advanced immunohistochemistry and confocal
microscopy has already allowed us to draw important conclusions
about their potential function(s). The current development of ex
vivo lung models for the selective identification of SMARs, NEBs
and VPRs using vital staining will certainly facilitate direct
physiological studies of these morphologically well-characterised
airway receptors, since these models allow direct live studies of
their functional properties.
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