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Books > Science & Mathematics > Chemistry > Physical chemistry > Nuclear chemistry, photochemistry & radiation
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PET Chemistry - The Driving Force in Molecular Imaging (Paperback, 2007 ed.)
Loot Price: R4,745
Discovery Miles 47 450
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PET Chemistry - The Driving Force in Molecular Imaging (Paperback, 2007 ed.)
Series: Ernst Schering Foundation Symposium Proceedings, 62
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Personalized medicine employing patient-based tailor-made
therapeutic drugs is taking over treatment paradigms in a variety
of ?elds in oncology and the central nervous system. The success of
such therapies is mainly dependent on ef?cacious therapeutic drugs
and a selective imaging probe for identi?cation of potential
responders as well as therapy monitoring for an early bene?t
assessment. Molecular imaging (MI) is based on the selective and
speci?c interaction of a molecular probe with a biological target
which is visualized through nuclear, magnetic resonance, near
infrared or other methods. Therefore it is the method of choice for
patient selection and therapy monitoring as well as for speci?c e-
point monitoring in modern drug development. PET (positron emitting
tomography), a nuclear medical imaging modality, is ideally suited
to produce three-dimensional images of various targets or
processes. The rapidly increasing demand for highly selective
probes for MI strongly pushes the development of new PET tracers
and PET chemistry. 'PET chemistry' can be de?ned as the study of
positron-emitting compounds regarding their synthesis, structure,
composition, reactivity, nuclear properties and processes and their
properties in natural and - natural environments. In practice PET
chemistry is strongly in?uenced by the unique properties of the
radioisotopes used (e. g. , half-life, che- cal reactivity, etc. )
and integrates scienti?c aspects of nuclear-, organic-, inorganic-
and biochemistry.
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