Can one correlate the philosophical musings of one of the most famous football coaches in history with the best ACS Student Member Chapters? Yes! The link is in the excellence. Award-winning Student Member Chapters-several leaders of which have been kind enough to write a chapter in this volume-all have caught excellence in one or more facets of what they do. Mio and Benvenuto began this journey to capture the best of Student Member Chapters back in 2015, when they asked some of the best and most active organizations' leadership to put into words what they did that puts them at the top. The editors realized there is not one, specific answer to such questions, but found a wealth of information in what their chapter authors reported. There are more voices in this wonderful chorus, voices of leaders who have great ideas and who have figured out ways to make the fascination of chemistry communicable to our students and the general public. This volume represents some excellent input as to what makes a chapter award-winning, and what keeps its excellence sustainable.

This book examines the history and fundamentals of the physical organic chemistry discipline. With the recent flowering of the organic synthesis field, physical organic chemistry has seemed to be shrinking or perhaps is just being absorbed into the toolkit of the synthetic chemist. The only Nobel Prize that can be reasonably attributed to a physical organic chemist is the 1994 award to George Olah, although Jeffrey I. Seeman has recently made a strong case that R. B. Woodward was actually a physical organic chemist in disguise (I). 2014 saw the awarding of the 50th James Flack Norris Award in Physical Organic Chemistry. James Flack Norris was an early physical organic chemist, before the discipline received its name. This book provides insight into the fundamentals of the field, and each chapter is devoted to a major discovery or to noted physical organic chemists, including Paul Schleyer, William Doering, and Glen A. Russell.

This book brings together the latest perspectives and ideas on teaching modern physical chemistry. It includes perspectives from experienced and well-known physical chemists, a thorough review of the education literature pertaining to physical chemistry, a thorough review of advances in undergraduate laboratory experiments from the past decade, in-depth descriptions of using computers to aid student learning, and innovative ideas for teaching the fundamentals of physical chemistry. This book will provide valuable insight and information to all teachers of physical chemistry.

Aggregation-induced emission (AIE) stands for an intriguing phenomenon in which a series of non-emissive molecules in solutions are induced to emit strongly in the aggregate or solid state. The concept of AIE was first coined by author Ben Zhong Tang in 2001, when he and his co-workers serendipitously discovered that 1-methyl-1,2,3,4,5-pentaphenylsilole was almost non-emissive in ethanol solution but became extremely bright in water-ethanol mixtures. Over the past 15 years, AIE has grown into a research field with high visibility and broad impact across both science and technology. Aggregation-Induced Emission: Materials and Applications summarizes the recent advances in AIE research, ranging from fundamentals, such as design, synthesis, and optical properties of AIE-active molecules, to mechanism studies supported by modeling and experimental investigations, and further to promising applications in the fields of energy, environment, and biology. The topics covered in Volume 2 include: AIE polymers; AIE-induced chirogenesis; Room-temperature phosphorescent AIE molecules; Liquid crystalline AIE molecules; AIE materials for energy devices; New chemo- and biosensors with AIE molecules; Cell structure and function imaging with AIE molecules; and AIE materials in drug delivery and therapy.

The role of the Maillard reaction in forming flavors from amino acid and sugar precursors has been studied for many years. To establish the basic chemistry of the reaction, researchers have used model systems, often solutions of a single amino acid with a single sugar. Despite the apparent simplicity of the system, heating such a solution can generate tens if not hundreds of compounds, which requires careful and time-consuming analysis to identify and quantify each component.
Data from the model systems has allowed researchers to study the pathways that lead to flavor formation, and various schemes have been proposed to identify the main "routes" that lead to flavor compounds. Such schemes have led to one of the main control principles, namely an understanding of the role of amino acids in forming some characteristic aromas, e.g., bread flavor from proline, as well as an appreciation of the role of C5 and C6 sugars in controlling the rate of reaction.
Recently, the formation of taste compounds through the Maillard reaction has been investigated and new potent compounds have been discovered that can contribute to the overall flavor formed during the Maillard reaction. These findings also offer the potential for control and manipulation of the Maillard reaction to form specific types of flavor. Although the nature of the end-products of the Maillard reaction in both food and model systems are well documented, applying these principles to control flavor formation in real foods has proved difficult.
This book describes recent research and developments related to the control of the Maillard reaction to give optimum flavor quality. These include kinetic modeling of the reaction, the effect of physical parameters (temperature, time, moisture content, pH), and the effect of chemical parameters (amino acid and sugar composition, the presence of other components). The topics covered relate to real food systems and reaction product flavorings, as well as model systems. Contributors from academia and industry have come together to provide an up to date overview of progress in this important area of flavor research.

This book focuses on broadly defined areas of chemical information science- with special emphasis on chemical informatics- and computer-aided molecular design. The computational and cheminformatics methods discussed, and their application to drug discovery, are essential for sustaining a viable drug development pipeline. It is increasingly challenging to identify new chemical entities and the amount of money and time invested in research to develop a new drug has greatly increased over the past 50 years. The average time to take a drug from clinical testing to approval is currently 7.2 years. Therefore, the need to develop predictive computational techniques to drive research more efficiently to identify compounds and molecules, which have the greatest likelihood of being developed into successful drugs for a target, is of great significance. New methods such as high throughput screening (HTS) and techniques for the computational analysis of hits have contributed to improvements in drug discovery efficiency. The SARMs developed by Jurgen and colleagues have enabled display of SAR data in a more transparent scaffold/functional SAR table. There are many tools and databases available for use in applied drug discovery techniques based on polypharmacology. The cheminformatics approaches and methodologies presented in this volume and at the Skolnik Award Symposium will pave the way for improved efficiency in drug discovery. The lectures and the chapters also reflect the various aspects of scientific enquiry and research interests of the 2015 Herman Skolnik award recipient.

Low-Energy Nuclear Reactions and New Energy is a summary of selected experimental and theoretical research performed over the last 19 years that gives profound and unambiguous evidence for low energy nuclear reaction (LENR), historically known as cold fusion.
In 1989, the subject was announced with great fanfare, to the chagrin of many people in the science community. However, the significant claim of its discoverers, Martin Fleischmann and Stanley Pons, excess heat without harmful neutron emissions or strong gamma radiation, involving electrochemical cells using heavy water and palladium, has held strong.
In recent years, LENR, within the field of condensed matter nuclear science, has begun to attract widespread attention and is regarded as a potential alternative and renewable energy source to confront climate change and energy scarcity. The aim of the research is to collect experimental findings for LENR in order to present reasonable explanations and a conclusive theoretical and practical working model.
The goal of the field is directed toward the fabrication of LENR devices with unique commercial potential demonstrating an alternative energy source that does not produce greenhouse gases, long-lived radiation or strong prompt radiation. The idea of LENR has led to endless discussions about the kinetic impossibility of intense nuclear reactions with high coulomb barrier potential. However, recent theoretical work may soon shed light on this mystery.
Understanding this process is one of the most challenging and perhaps important issues in the scientific world. This book includes previously unpublished studies, new and controversial theories to approach LENR with access to new sources and experimental results. The book offers insight into this controversial subject and will help readers re-evaluate their perspective on LENR as a possible alternative energy source.

Chemometrics and Chemoinformatics gives chemists and other scientists an introduction to the field of chemometrics and chemoinformatics. Chemometrics is an approach to analytical chemistry based on the idea of indirect observation. Measurements related to the chemical composition of a substance are taken, and the value of a property of interest is inferred from them through some mathematical relation. Basically, chemometrics is a process. Measurements are made, data is collected, and information is obtained to periodically assess and acquire knowledge. This, in turn, has led to a new approach for solving scientific problems: (1) measure a phenomenon or process using chemical instrumentation that generates data inexpensively, (2) analyze the multivariate data, (3) iterate if necessary, (4) create and test the model, and (5) develop fundamental multivariate understanding of the process. Chemoinformatics is a subfield of chemometrics, which encompasses the analysis, visualization, and use of chemical structural information as a surrogate variable for other data or information. The boundaries of chemoinformatics have not yet been defined. Only recently has this term been coined. Chemoinformatics takes advantage of techniques from many disciplines such as molecular modeling, chemical information, and computational chemistry. The reason for the interest in chemoinformatics is the development of experimental techniques such as combinatorial chemistry and high-throughput screening, which require a chemist to analyze unprecedented volumes of data. Access to appropriate algorithms is crucial if such experimental techniques are to be effectively exploited for discovery. Many chemists want to use chemoinformatic methods in their work but lack the knowledge required to decide which techniques are the most appropriate.

Following Ionic Liquids: Industrial Applications to Green Chemistry, SS #818, by the same editors, this book focuses on exciting new developments in ionic liquids.

Developing innovative efficient and sensitive spectroscopic and optical techniques for studying biomedically relevant molecules, structures and processes in vitro and in vivo is a field of rapidly growing interest. This symposium book covers novel and exciting approaches in biomedical spectroscopy. Several chapters deal with infrared and Raman spectroscopy. These complimentary vibrational spectroscopic techniques are capable of monitoring molecular structures as well as structural changes. Such studies are of interest for understanding diseases at a molecular level as well as for developing techniques for efficient early diagnosis based on molecular structural information. The chapters demonstrate also applications vibrational spectroscopy in proteomics and the characterization of micro organisms. The second section of the book introduces surface enhanced Raman scattering (SERS), demonstrates the application of the effect in the biomedical field and develops the concept of multifunctional nanosensors. The measurement of intrinsic optical signals from biological objects such as nerve tissue are discussed in the next section of the book. Chapters deal also with Coherent anti-Stokes Raman scattering (CARS) and fluorescence fluctuation spectroscopy. Other chapters illustrate how photons of very different energies, in the Terahertz and in the ultra violet range, can be used to retrieve molecular structural information from native biomolecules. The electrical properties of protein molecules adsorbed onto a gold substrate are studied by using a scanning Kelvin nanoprobe in a microarray format. The final chapters in the book demonstrate the powerful combination of different spectroscopic techniques for the characterization of biomolecules as well as native and engineered biomaterials. These chapters combine information from Raman and Inelastic Neutron Scattering, optical absorbance and energy dispersive X-ray analysis, positron annihilation lifetime spectroscopy (PALS), 1H NMR, and 129Xe NMR X-ray diffraction and fluorescence resonance energy transfer.

The interactions of microbes with surfaces are important to many natural and engineered processes, affecting a wide range of applications from decontamination of surfaces or drinking water, prevention of microbial colonization of biomaterials, and bacterial processes in the environment. Therefore, there is great interest in understanding the fundamental behavior of microbes at surfaces. Topics are included that address interactions of cells with a number of surfaces for antifouling and microbial cell-based sensor applications; mechanistic studies of antimicrobial peptides and quorum sensing; exploration of experimental and theoretical models of a cell surface; cell surface display of peptides and enzymes as biofabrication techniques; the fate and transport of bacteria in the natural environment, as well as new experimental tools or modeling techniques to study interactions at the microbial surface.
While most of the papers are geared towards a specific application, they all contain fundamental information regarding bacterial behavior at interfaces that allows their contents to translate to other problems, as well. For example, many parallels are noted between the way bacteria interact with proteins-coated polymers on a catheter and bacterial-peptide interactions in a cellular detection assay. An overlying theme of all the manuscripts is that they represent studies of microbial interfaces using the most sophisticated experimental and modeling tools available, and many feature interdisciplinary approaches to tackling the given problems.

The purpose of this book is to provide an update on some of the latest research and applications in the broad field of ionic liquids. This volume spans research and development activities ranging from fundamental and experimental investigations to commercial applications. A brief history of the field is included, as well as both new developments and reviews organized in the general topical areas of applications, materials, biomass processing, and fundamental studies. This book attempts to propel the field forward by bringing together contributions from some of the foremost researchers on ionic liquids. Recent products and new large-scale processes using ionic liquids, both in operation and being announced, indicate that an exciting new chapter in this field is about to begin. The authors summarize some of the history, applications, conferences, books, databases, issues related to data quality and toxicity for researchers working in the field of ionic liquids and includes an overview for each proceeding chapter with an introduction about the authors.

The field of quantum chemistry has grown so immensely that the importance of some of the earliest work and the earliest pioneers of quantum chemistry is unfamiliar to many of today's youngest scientists in the field. Thus, this book is an attempt to preserve some of the very valuable, early history of quantum chemistry, providing the reader with not only a perspective of the science, but a perspective of the early pioneers themselves, some of whom were quite interesting characters. The symposium on which this book is based came about because one of the co-editors (ETS) came to a conviction that the contributions such as those by George Wheland to quantum chemistry and Otto Schmidt to free electron theory should be better appreciated and known. He organized a symposium in which quantum chemistry pioneers, both those celebrated by everyone and those seemingly overlooked by posterity, would be recognized. While this volume is certainly not a history of quantum chemistry, it does cover many highlights over a period of about sixty years. This volume consists of chapters based upon ten of the presentations at the symposium "Pioneers of Quantum Chemistry" held March 28, 2011, at the 241st ACS National Meeting in Anaheim, CA.

This is the long awaited sequel to Classics in Total Synthesis, a book that has made its mark as a superb tool for educating students and practitioners alike in the art of organic synthesis since its introduction in 1996. In this highly welcomed new volume, K. C. Nicolaou and Scott A. Snyder discuss in detail the most impressive accomplishments in natural product total synthesis during the 1990s and the first years of the 21st century. While all of the features that made the first volume of Classics so popular and unique as a teaching tool have been maintained, in this new treatise the authors seek to present the latest techniques and advances in organic synthesis as they beautifully describe the works of some of the most renowned synthetic organic chemists of our time. Develops domino reactions, cascade sequences, biomimetic strategies, and asymmetric catalysis are systematically through the chosen synthesis Discusses the latest synthetic technologies in terms of mechanism and scope Includes new reactions, such as olefin metathesis, in mini-review style Abundant references for further reading CD with useful teaching material for lecturers is included with hardback version (ISBN 3-527-30685-4) Graduate students, educators, and researchers in the fields of synthetic and medicinal chemistry will wish to have a copy of this book in their collection as an indispensable companion that both augments and supplements the original Classics in Total Synthesis.
From reviews of "Classics in Total Synthesis":

.,." a volume, (..) which any chemist with an interest in synthetic organic chemistry will wish to acquire."
"JACS"

.,."this superb book (..) will be an essential purchase formany organic chemists."
"Nature"

More than four decades have passed since surface-enhanced Raman scattering (SERS) was discovered. In today's world SERS has been established as a plasmon-based spectroscopy with ultra-high sensitivity and versatility at the forefront of the developments in plasmonics. SERS has been developing with the advances in nanoscience and nanotechnology. The "SERS world" has grown up markedly for the last 20 years or so, and recently the wider concept of, plasmon-enhanced spectroscopy was born. Plasmon-enhanced spectroscopy contains not only SERS but also tip-enhanced Raman scattering (TERS), surface-enhanced infrared absorption (SEIRA), surface-enhanced fluorescence (SEF), and more. Through these novel spectroscopies various amazing properties of plasmons have become known, providing new exciting research fields. One of the main purposes of the book is to convey the enthusiastic discussion on plasmon-enhanced spectroscopy at the symposium to the scientific community. This book reports leading-edge advances in the theory of plasmonic enhancement and application of plasmon-enhanced spectroscopy to biology, chemistry, physics, materials science, and medicine. Many books have been published about SERS, but this may be the first time that a book on a wide area of plasmon-enhanced spectroscopy has ever been published. The book consists of two volumes; the second volume discusses TERS, SEIRA, and other topics related to plasmon-enhanced spectroscopy.

This series deals with important issues in stereochemistry, which is the three-dimensional spatial orientation of molecules, also called the chirality (or handedness) of molecules. Topics in Stereochemistry, previously edited by "the father of stereochemistry" Ernest L. Eliel, is a longstanding, successful series covering the most important advances in the field. The much-anticipated Volume 26 on stereochemical aspects of organolithium compounds includes chapters on Asymmetric Deprotonations Using Chiral Lithium Amide Bases, Self-Regeneration of Stereocenters (SRS) via Stereolabile Axially Chiral Intermediates, and more.

Engel and Reid's Physical Chemistry gives students a contemporary and accurate overview of physical chemistry while focusing on basic principles that unite the sub-disciplines of the field. The Third Edition continues to emphasize fundamental concepts and presents cutting-edge research developments that demonstrate the vibrancy of physical chemistry today.

More than four decades have passed since surface-enhanced Raman scattering (SERS) was discovered. In today's world SERS has been established as a plasmon-based spectroscopy with ultra-high sensitivity and versatility at the forefront of the developments in plasmonics. SERS has been developing with the advances in nanoscience and nanotechnology. The "SERS world" has grown up markedly for the last 20 years or so, and recently the wider concept of, plasmon-enhanced spectroscopy was born. Plasmon-enhanced spectroscopy contains not only SERS but also tip-enhanced Raman scattering (TERS), surface-enhanced infrared absorption (SEIRA), surface-enhanced fluorescence (SEF), and more. Through these novel spectroscopies various amazing properties of plasmons have become known, providing new exciting research fields. One of the main purposes of the book is to convey the enthusiastic discussion on plasmon-enhanced spectroscopy at the symposium to the scientific community. This book reports leading-edge advances in the theory of plasmonic enhancement and application of plasmon-enhanced spectroscopy to biology, chemistry, physics, materials science, and medicine. Many books have been published about SERS, but this may be the first time that a book on a wide area of plasmon-enhanced spectroscopy has ever been published. The book consists of two volumes; the first volume contains the introductory review by George Schatz followed by eight chapters, which are mainly concerned with SERS.

Colorimetry is concerned with the measurement of, and discrimination between, colours. These are important topics in a wide range of the physical sciences, life sciences, and computing and engineering. Examples of specific areas where the techniques of colorimetry are used are: manufacturers of paints, textiles, plastics and cosmetics (and quality controllers in these industries), those interested in the effect of light in human environments (for example, in terms of its direct effects on the eye, laser safety and design of eye protection and ergonomics of hospital lighting), psychology, physiology and those involved in the technical aspects of photography. The book presents the physiological background behind how colour is perceived and discusses sources of visible radiation, before going on to describe in detail colorimetric techniques for measuring and discriminating between colours. Applications of these techniques are discussed and relevant mathematical data is provided. The book gives a comprehensive account of the physiological aspects of colour, the development of photometry and colorimetry, and applications of colorimetry in a single volume.