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Basics of PET Imaging - Physics, Chemistry, and Regulations (Paperback, 2nd ed. 2010)
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Basics of PET Imaging - Physics, Chemistry, and Regulations (Paperback, 2nd ed. 2010)
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Sincethepublicationofthisbook in2005, thegrowthofpositron emission
tomography(PET)andPET/CTmodalityhasbeenphenomenalwiththed-
coveryofef?cientdetectorsandtheadditionofsophisticatedscannersand
powerfulsoftware. Becauseofthevastadvancementandchangesintechn-
ogy, andalso withgreatappreciationofthesuccess ofthe?rst edition,
we thoughtasecondeditionofthebookwouldbeappropriate.
Thebookisrevisedtoagainful?lltheneedsofnuclearmedicineprof-
sionalssuchasphysicians, technologists, andresidents,
alongwithstudents fortheirboardexaminationandtraining.
Thecontentsofthebookhavebeen
keptatthebasiclevelaswasinthe?rstedition. The organization of the
book essentially has remained the same. Some
chaptershavebeenrevisedvery extensively, while others haveonly
minor changes. NochangehasbeenmadeinChap.
1asitisbasedonbasicphysics. Extensive revision has been made in
Chaps. 2 and 3 to include up-to-date information on detectors,
scanners, and data collection. Chapter 4 in the original edition
has been divided into Chaps. 4 and 5 to allow for a se-
ratechapteron"Storage,Display,andPACS. "Chapter6hasbeenupdated
withnewinformationonNEMAstandardsonacceptancetestsofPETsc- ners.
NewPETradionuclidesandthelistofcurrentavailablecyclotronshave
beenaddedtoChap. 7. Chapter8includesasectiononCompoundingofPET
Radiopharmaceuticals,inadditiontoseveralnewPETradiopharmaceuticals.
NewregulationsconcerningtheuseofPETradiopharmaceuticals,thelice-
ingofphysiciansandtechnologists,andtheaccreditationofPETfacilitiesto
beeligibleforreimbursementforPETproceduresareallincludedinChap. 9.
Chapter10hasbeenrevised,focusingontheissuesofcurrentreimbursement
issuesforPETstudies. OnlyminorchangeshavebeenmadeinChaps. 11and
12toincludeup-to-dateinformation. Questionshavebeenaddedattheend
ofeachchapter,asappropriate,tore?ectthechangesincontents.
IthankmycolleaguesattheClevelandClinicFoundationfortheirsupport in
manywaysand Mrs. DianeGrif?s for kindly typingand completingthe
manuscriptontime. vii viii Preface
IsincerelythankAndrewMoyer,editorofradiologyandnuclearmedicine,
atSpringerforsupportandencouragement,andS. GeethalakshmiSrinivasan,
ProjectManager,atSPiTechnologiesIndiaPvtLtdforexcellentproduction
ofthebook. Cleveland,OH GopalB. Saha Contents 1.
RadioactiveDecayandInteractionofRadiationwithMatter ...1
AtomicStructure ...1 RadioactiveDecay ...2 ?Decay ...2 ? ? Decay
...3 + Positron(?) Decay ...3 ElectronCapture ...3
IsomericTransition ...4 RadioactiveDecayEquations ...5
GeneralDecayEquations ...5 SuccessiveDecayEquations ...7
UnitsofRadioactivity ...9
UnitsofRadioactivityinSystemInternationale ...9 Calculations ...9
InteractionofRadiationwithMatter ...10
InteractionofChargedParticleswithMatter ...10
Interactionof?RadiationwithMatter ...12 Questions ...15
ReferencesandSuggestedReading ...17 2. PET ScanningSystems ...19
Background ...19 SolidScintillationDetectorsinPET ...20
PhotomultiplierTube ...24 PulseHeightAnalyzer ...25
ArrangementofDetectors ...25 PETScanners ...28
CoincidenceScintillationCameras ...29 PET/CTScanners ...30
SmallAnimalPETScanner ...33 MobilePETorPET/CT ...36 ix x Contents
Questions ...38 ReferencesandSuggestedReading ...39 3.
DataAcquisition and Corrections ...41 PETDataAcquisition ...41
TimeofFlightMethod ...46 Two-Dimensionalvs. Three-Dimensional
DataAcquisition ...47 FactorsAffectingAcquiredPETData ...49
Normalization ...49 PhotonAttenuation ...50
AttenuationCorrectionMethods ...52 RandomCoincidences ...53
ScatterCoincidences ...55 CorrectionforScatterCoincidences ...56
DeadTime ...58 RadialElongation ...59 PET/CTDataAcquisition ...6 0
FactorsAffectingPET/CTData ...62 Questions ...67
ReferencesandSuggestedReading ...68 4. ImageReconstruction ...71
SimpleBackprojection ...71 FilteredBackprojection ...72
TheFourierMethod ...73 TypesofFilters ...75 IterativeReconstruction
...
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