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Boron Neutron Capture Therapy - Toward Clinical Trials of Glioma Treatment (Paperback, Softcover reprint of the original 1st ed. 1992)
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Boron Neutron Capture Therapy - Toward Clinical Trials of Glioma Treatment (Paperback, Softcover reprint of the original 1st ed. 1992)
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The European Collaboration on Boron Neutron Capture Therapy (BNCT),
conceived in 1987 and successful in 1989 in gaining financial
support as a Concerted Action through the Medical and Health
Research Programme of the Commission ofthe European Communities
(CEC) in Brussels, considered it an opportune moment to hold its
annual Plenary Meeting on 18-20 Septem ber 1991 as an International
Workshop entitled "Towards Clinical Trials of Glioma with BNCT".
The background to this consideration was influenced by the
world-wide resurgence ofinterest in NCT over the last 2 decades and
by the exemplifica tions at the Fourth International Symposium on
Neutron Capture Therapy for Cancer held in Sydney in December 1990,
where it was strongly indicated that within the next 2 years
clinical trials would be started both in Europe and the United
States. In particular at the High Flux Reactor of the Joint
Research Centre of the CEC at Petten in The Netherlands, an
epithermal neutron beam designed and installed in the summer of
1990 recently became operable at full reactor power. An extensive
series ofexperiments, including the nuclear and radiobiological
characterisation of the beam and a healthy tissue tolerance study
on canines has started and has the aim to define the preconditions
for clinical trials onpatients with Grade III/IV glioma. However,
as with any other new therapy modality, it must be demon strated
that BNCT is safe for the patient and has a reasonable chance of
being an effective therapy.
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