Skull base anatomy is extremely complex, with vital neurovascular structures passing through multiple channels and foramina. Brain tumors such as pituitary tumors, acoustic neuromas, and meningiomas are challenging to treat due to their close proximity to cranial nerves and blood vessels in the brain, neck, and spinal cord. Medical imaging is an essential tool for identifying lesions and critical adjacent structures. Detecting and precisely mapping out the extent of disease is imperative for appropriate and optimal treatment planning and ultimately patient outcome. Eugene Yu and Reza Forghani have produced an exceptional, imaging-focused guide on various neoplastic diseases affecting the skull base, with contributions from a Who's Who of prominent radiologists, head and neck surgeons, neurosurgeons, and radiation oncologists. The content is presented in a clear and concise fashion with chapters organized anatomically. From the Anterior Cranial Fossa, Nasal Cavity, and Paranasal Sinuses - to the Petroclival and Lateral Skull Base, an overview and detailed analysis is provided for each region. Key Highlights Fundamentals of skull base imaging, including recent developments in diagnostic modalities More than 400 radiographs, color anatomical drawings, and color intraoperative photos elucidate the imaging appearances of a wide spectrum of disease affecting the skull base, as well as important anatomic variants and pathways of disease spread Clinically oriented imaging approach focuses on diagnostic and prognostic features important in the evaluation of skull base abnormalities Atlas of skull base CT and MRI anatomy provides an easy to access, quick reference for identifying important anatomic landmarks Insights on the pathways of tumor growth and the role of clinical imaging in the management of skull base cancers Critical and contrasting viewpoints from multidisciplinary experts provide a well-rounded perspective This invaluable resource chronicles current knowledge in state-of-the-art skull base tumor imaging with clinical pearls on pathophysiology, prognosis, and treatment options. It is a must-have for radiology, neurosurgery, and otolaryngology residents and clinicians who care for patients with head and neck neoplasms.

Super-Resolution imaging refers to modern techniques of achieving resolution below conventional limits. This book gives a comprehensive overview of mathematical and computational techniques used to achieve this, providing a solid foundation on which to develop the knowledge and skills needed for practical application of techniques. Split into five parts, the first looks at the mathematical and probabilistic tools needed, before moving on to description of different types of imaging; single-wave, anomaly, multi-wave and spectroscopic and nanoparticle.As an important contribution to the understanding of super-resolution techniques in biomedical imaging, this book is a useful resource for scientists and engineers in the fields of biomedical imaging and super-resolution, and is self-contained reference for any newcomers to these fields.

This issue of PET Clinics focuses on PET/MRI: Clinical Applications, and is edited by Drs. Drew Torigian and Andreas Kjaer. Articles will include: PET/MRI in Prostate Cancer; PET/MRI in Vascular Disease; PET/MRI in Lymphoma; PET/MRI in Head and Neck Cancer; PET/MRI in Brain Disease; PET/MR in Cancers of GI Tract; PET/MRI in Gynecologic Cancer; Clinical PET/MRI Systems and Patient Workflow; PET/MRI in Heart Disease; PET/MR in Breast Cancer and Lung Cancer; PET/MRI in Musculoskeletal Disorders; PET/MRI in Pediatric Oncology; Clinical PET/MRI: Future Perspectives; and more!

Ultrasound has been imaging modality of poor man since 50 years. With computer revolution it has acquired exquisite quality at turn of century. Its capabilities have not yet been fully recognized and described.

This issue of PET Clinics examines normal variations and benign findings in FDG PET/CT Imaging. Topics include Standardization and quantification in FDG PET /CT imaging for staging and restaging of disease, dynamic changes in FDG update in normal tissues, as well as normal variations in the brain, head and neck, thorax, abdomen, pelvis, and in pediatrics.

The quintessential case-based review to prep for and master ABR exams The American Board of Radiology Core, Certifying, and Neuroradiology Subspecialty Exams test an individual's knowledge and understanding of anatomy, pathophysiology, and physics concepts important in diagnostic imaging. For many residents, fellows, and practicing radiologists, preparation for these exams involves several months to years of reading text, interpreting images, and answering countless questions. Neuroradiology Q&A for the Radiology Boards, edited by neuroradiologist Michael Iv, features contributions from other academic neuroradiologists at Stanford University who are passionate about education and paying it forward. The primary goals of this book are to help current and future generations of radiologists ace the neuroradiology section of these exams and improve their clinical skills. The reader-friendly compilation of cases, questions, and answers reflects the invaluable insights of neuroradiologists who recently experienced the arduous journey of studying and sitting for the ABR exams. The book consists of a collection of 100 "standard difficulty" and "challenging" cases organized by the categories of brain, spine, and head and neck. A total 70 cases covering a wide range of brain conditions and diseases include 20 challenging cases. Spine and head and neck pathologies are represented by 15 cases each, both of which include 5 challenging cases. All of the cases illustrate specific pathologies and teaching points likely to be encountered on the exams and in the reading room. Key Features Cases encompass every area of neuroradiology and cover the full age spectrum Consistently formatted cases feature two or three high-yield images, followed by three multiple choice questions that assess comprehension of imaging diagnosis, histopathology, and management Detailed explanations for correct and incorrect answers enhance understanding and acquisition of knowledge   This must-have study guide will help radiologists prepare for and ace the Core, Certifying, and/or Neuroradiology Subspecialty ABR exams and improve their clinical knowledge, which ultimately leads to improved patient care. This print book includes complimentary access to a digital copy on https://medone.thieme.com.

Der Verdacht auf eine Erkrankung des Gehirns oder Ruckenmarks verursacht bei betroffenen Eltern und Kindern Angst und Verunsicherung. Deshalb mussen behandelnde AErzte schnell und prazise diagnostizieren. Optimale Unterstutzung bietet dieses Lehrbuch und Nachschlagewerk. Es ermoeglicht rasche Orientierung und den leichten Zugang. Knapp und ubersichtlich: Entstehung und Diagnose haufiger Krankheitsbilder, Krankheiten, die bestimmte Entwicklungskonzepte gut veranschaulichen, seltene Erkrankungen im Kurz-UEberblick. Klar und verstandlich: einpragsame Merksatze, UEbersichtstabellen, Entscheidungshilfen, Praxis-Tipps, Glossar radiologischer Fachbegriffe zum Nachschlagen. Einsteiger lernen leicht und Experten klaren schnell diagnostische Fragen.

Drs. Vitola and Delbeke assembled a group of standout contributors in order to create a resource that advances the knowledge and skills of experienced nuclear cardiologists and radiologists while also preparing residents for the cutting-edge field of nuclear cardiology. Diagnostic tools, physics and instrumentation, and radiopharmaceuticals and protocols central to the field are examined. The comprehensive text covers key applications of myocardial perfusion imaging, including applications in special populations and in emergency departments. Risk assessment, pitfalls, and artefacts are addressed. Additional chapters detail the value of cardiac MRI, multislice computed tomography, stress echocardiography, and PET and PET/CT to nuclear cardiology. Practical case presentations and a wealth of illustrations reinforce instruction on diagnostic guidelines and methods.

Imaging-Guided Interventional Breast Techniques instructs the reader on the performance of invasive breast procedures and discusses issues related to the selection and purchase of equipment to perform these cutting edge techniques. This "how to" text will include the most up-to-date information on biopsy technology, including the advantages and disadvantages of biopsy probes. The book will also address issues of patient management and discuss the results of the latest stuides on problems in the histopathologic interpretation of tissue obtained during biopsies. Additionally, the book is designed to assist the physician in assessment of equipment in compliance with professional regulations. Enhanced by over 200 high quality images, this text is ideal for specialists who perform interventional breast procdures.

biochemische und okologische Aspekte der Resistenzentstehung in Mikro- organismen und in Tumorzellen, Probleme und Moglichkeiten der kombinierten Anwendung von Chemotherapeutika und die logistischen und wissenschaftlichen Grundlagen fUr die Suche nach neuen Chemotherapeutika abgehandelt. Die Frage nach den Urspriingen der Chemotherapie fUhrt auch zu den Schwachen, die bereits im Konzept dieser therapeutischen Disziplin liegen und die der An- wendung der Chemotherapie Grenzen setzen. Von dies en Grenzen und von Moglichkeiten, sie zu uberwinden, ist im letzten Kapitel die Rede. DaB ein Text wie der vorliegende nicht alle Aspekte der Chemotherapie in gleicher Ausftihrlichkeit behandeln kann, versteht sich fast von selbst. Dieses Buch enthalt keine enzyklopadische Darstellung der Chemotherapie, sondern die Erlauterung einiger ihrer prinzipiellen Probleme. DaB die hierzu herangezogenen Beispiele vorwiegend aus der antimikrobiellen und antineoplastischen Chemo- therapie stammen, hangt mit den personlichen Interessen und Erfahrungen des Autors zusammen. An einigen Stellen des Buches werden Fragen erortert, die noch ungelost sind. Zuweilen wird in einer kontroversen Frage sogar Partei ergriffen. Der Autor hofft, die "Subjektivitat" derartiger AuBerungen deutlich genug kenntlich ge- macht zu haben. 1m ubrigen dilrften so1che gelegentlich unterlaufenen Abwei- chungen yom Tugendpfad der Lehrbuchtradition der Lebendigkeit der Darstel- lung zugute kommen. Dieses Buch mochte nicht nur informieren, es will auch anregen und zum Widerspruch herausfordern. Mit diesem Anliegen wendet es sich an aIle, die sich mit der Chemotherapie beschiiftigen wollen oder die Chemotherapie bereits in irgendeiner Form praktizieren, also an Medizinstuden- ten, Ante, Mikrobiologen und Pharmakologen.

This open access book presents a wide portfolio of examples of positron emission tomography coupled with computer tomography (PET/CT) studies in various cardiac conditions in order to provide a rationale for the implementation of this technology in an array of clinical conditions. Cardiovascular diseases are a major contributor to premature morbidity and mortality worldwide. Low- and middle-income countries (LMICs) are particularly affected by cardiovascular diseases (CVDs), with more than 75% of all CVDs deaths occurring in these countries. For this reason, target 3.4 of the United Nations (UN) Sustainable Development Goals (SDGs) agenda aims at a 30% reduction in premature mortality due to non-communicable diseases (NCDs), which include CVDs, by 2030. Among CVDs, ischemic heart disease (IHD) plays an important role and, according to the Institute for Health Metrics and Evaluation (IHME), it was responsible for 15.96% of global deaths in 2017. Between 2000 and 2017, the number of IHD deaths worldwide increased by 0.26% per year. Several imaging tools help to non-invasively diagnose, stratify risk and guide management in cardiac disease. They include nuclear cardiology techniques, using either SPECT (single photon emission computed tomography) or PET/CT. While myocardial imaging with SPECT has been fully embraced by the cardiology community and is widely available worldwide, PET/CT introduction has been slower, due not only to its higher costs, but also to the limited availability of PET/VCT scanners, mostly utilized for oncological applications. This book is an invaluable tool for nuclear medicine physicians, cardiologists and radiologists.

Atlas of Nuclear Cardiology provides detailed guidance on how to and how not to perform imaging studies so you can get the best image quality and avoid artifacts. Ami E. Iskandrian and the editorial team responsible for Braunwald's Heart Disease bring you the most clinically relevant, case-based, evidence-based, practical, and contemporary atlas of nuclear cardiology. High-quality, full-color images ensure that you get the possible results. Access the fully searchable contents online at www.expertconsult.com, along with a moving image library that demonstrates myocardial perfusion imaging, myocardial tracers, PET, PET-CT, and gated SPECT. Stay current on recent developments in nuclear cardiac imaging such as equilibrium radionuclide angiocardiography (ERNA) and first-pass radionuclide angiography (FPRNA). Master the application of techniques to specific clinical situations with detailed case studies and discussions of challenging issues. Gain a clear visual understanding from numerous, high-quality images in full color. Find information quickly and easily thanks to a practical, consistent format throughout the text. Master nuclear imaging with the practical, case-based information you need, from the Braunwald experts you trust

This book aims to be the most comprehensive coverage of the topics covered in the new look First Fellowship of Royal College of Radiology (FRCR) examination, which includes new topics such as ultrasound and magnetic resonance.
Led by specialist trainees with recent exam experience and contributions from experienced senior consultants and examiners, this book offers not only relevant content and valuable insights, but also visually enhanced answer sections (including diagrams and tables) that aim to improve and enhance understanding of key concepts in medical physics and radiation protection.
Each chapter includes up to forty multiple choice questions covering each area of the exam. Each question and answer includes explanations and further reading.

The updated, second edition of the textbook Applied Physics for Radiation Oncology, originally published in 1996 is intended for both radiation therapists and students of radiation therapy. Chapters cover treatment planning, photon and electron dosimetry, brachytherapy, methods of dose calculation, isodose curves, beam-modifying devices, patient and beam geometry, radiation protection, and clinical use and operation of linear accelerators. The authors unify the principles of radiation therapy physics with the real world of clinical practice. A must for radiation therapists.

Compiled from sessions presented at the 2008 AAPM Summer School, which was held June 25-27, 2008 at the Baylor College of Medicine, Texas Medical Center, Houston, TX. Topics include PET and CT basics, diagnostic and clinical alications, PET/CT scanner designs and characteristics, scanner testing, PET ACR accreditation and acceptance testing, PET/CT simulation for therapy alications, shielding calculations and radiation safety, and site planning.

A state-of-the-art guide on the interventional management of venous disease from renowned experts! The diagnosis and management of venous disorders is a core competency of interventional radiology, comprising up to 75% of an interventional radiologist's caseload in some institutions. Venous Interventional Radiology by prominent interventional radiologist Laura Findeiss and an impressive group of contributors is a highly practical vascular interventional radiology reference that covers a full spectrum of venous disease. The richly illustrated book starts with an opening chapter on venous anatomy, physiology, and epidemiology. Disease-specific chapters cover common to complex disorders, from varicose veins and venous ulceration, to thromboembolic disease and pulmonary embolism. Each chapter presents the latest minimally invasive image-guided interventions for the diagnosis and management of a specific disease. Clinical cases provide discussion of patient presentation/symptoms, clinical evaluation, procedural and non-invasive management strategies, and follow-up, all of which are key to delivering comprehensive patient care. Key Highlights Angiographic and cross-sectional imaging findings enhance knowledge of disease processes A chapter dedicated to vascular/venous access provides guidance on this basic yet critical component of patient care The classification, evaluation, and treatment of venous anomalies and syndromes The authors discuss pitfalls and complications, including their own pearls of wisdom and unanswered questions This highly practical guide is a must-have resource for trainee and veteran interventional radiologists and vascular surgeons. This book includes complimentary access to a digital copy on https://medone.thieme.com.

The present volume on basic physics of ultrasonographic imaging procedures provides clear and concise information on the physics behind ultrasound examinations in diagnostic imaging. It attempts to present the subject from a simple approach that should make it possible for the target groups to comprehend the important concepts which form the physical basis of ultrasonic imaging. The main target group of this manual is radiological technologists and radiographers working with diagnostic ultrasound in developing countries.Clinicians and nurse practitioners may also find the simple presentation appealing. A conscious effort has been made to avoid detailed mathematical treatment of the subject. The emphasis is on simplicity.

This monograph evaluates the evidence for carcinogenicity of ionizing radiation from internally deposited radionuclides. The radionuclides considered in this monograph belong to two broad categories: those that emit a-particles (helium nuclei) and those that emit b-particles (electrons) during their primary radioactive decay. For purposes of this monograph 'internally deposited' refers to radionuclides in dispersed forms (e.g. dusts suspensions solutions or gases) that enter the body through inhalation ingestion by some form of injection or in some cases by percutaneous absorption. Radionuclides may also enter tissues within removable objects, such as radioactive beads needles etc. that may be implanted surgically for therapeutic purposes or other kinds of fragments implanted accidentally. These kinds of exposures are not considered in this volume. Also not considered are radionuclides (e.g. iron-55 gallium-67) which undergo radioactive decay through processes that do not include emission of either a or b particles. Radon and its decay products were previously evaluated in "IARC Monographs" Volume 43 (1988) as "carcinogenic to humans" (Group 1). The subsequently published scientific literature on occupational and residential exposures to radon was reviewed and included in this volume as an update but no re-evaluation of radon was considered necessary. Six specific radionuclides of the elements radium thorium plutonium and phosphorus plus mixed radionuclides of iodine were evaluated as "carcinogenic to humans "(Group 1) on the basis of sufficient evidence for increased risk of cancer in exposed individuals. These include radium-224 radium-226 radium-228 thorium-232 (administered in colloidal form as thorium-232 dioxide) plutonium-239 (exposure to which also entails exposure to plutonium-240 and other isotopes of plutonium) radioisotopes of iodine including iodine-131 and phosphorus-32. Evidence for increased cancer risk in exposed humans is from medical usage in the cases of radium-224 thorium-232 and phosphorus-32 and from occupational or accidental/environmental exposures for plutonium-239 radium-226 and radium-228 and the radioiodines. In addition the global evaluations of two broad categories of internally deposited radionuclides were made on the basis of carcinogenicity in experimental animals plus other relevant data: Internally deposited radionuclides that emit a particles are "carcinogenic to humans (Group 1)." Internally deposited radionuclides that emit b particles are "carcinogenic to humans (Group 1). Ionizing Radiation Part 1: X-and Gamma (g) Radiation and Neutrons" Volume 75 of the "Monographs" addressed the carcinogenic potential of external X-rays g-rays and neutrons in exposed populations (see overleaf).

This book describes, in fascinating detail, a variety of experiments sponsored by the U.S. government in which people were exposed to radiation without their knowledge. After reviewing hundreds of thousands of documents from the Atomic Energy Commission and other agencies, the Advisory Committee appointed by President Clinton in January 1994 found that nearly 4,000 human radiation experiments--most involving very low doses of radioactive tracers--were sponsored by the federal government between 1944-1974. This book documents these findings to provide a fascinating if not disturbing reminder of both the shocking standards for human experimentation and the shrouded practice of government secrecy in recent history. Carried out at the height of the Cold War, experiments included feeding radioactive cereal to teenagers at a school for the mentally retarded, irradiating the testicles of prison inmates, injecting plutonium into hospital patients, and intentional releases of radiation into the environment. The book places these experiments within their historical context, and a review of the relevant government policies and ethics standards at the time is included. The analysis is then applied to contemporary research on human subjects. The book concludes with a discussion of the Committee's key findings and a set of recommendations for changes in in institutional review boards, the interpretation of ethics rules and policies, the conduct of research involving military personnel, the oversight and accountability for ethical violations, compensation for research injuries, and balancing national securities interests with the rights of the public. This compelling volume will prove to be a landmark in the development of standards for human experimentation. Ethicists, public health professionals and those interested in the history of medicine and Cold War history will be intrigued by the findings in this volume.

This new atlas, the fourth of a successful series, is a completely revised and updated edition of a previously published FDG PET-CT atlas. In the past few years, considerable progress has been made in the field of PET-CT imaging, and this new edition takes full account of these recent developments. Furthermore, its educational mission has been broadened: beyond serving as a straightforward guide to FDG PET-CT imaging it now encompasses the integrative use of contrast-enhanced CT and MRI. The new edition also includes non-oncological indications for FDG PET-CT. The atlas aims to help imaging practitioners to recognize physiological and benign pathological FDG uptake and illustrates in a case-based, practical manner the PET-CT appearances of all the major tumors and infectious, inflammatory, and neurodegenerative disorders. The main clinical applications are covered, and learning points and pitfalls are clearly articulated. The consistent, user-friendly format facilitates image interpretation and allows rapid review of key information needed for FDG PET-CT imaging.

Top Score for the Radiology Boards: Q & A for the Core and Certifying Exams is the ideal diagnostic radiology board prep resource. Written by radiologist Alan Weissman, with contributions from dozens of leading experts at renowned institutions, Top Score has a simple ambition: to improve your test scores. The book covers all exam categories, including non-interpretive skills (NIS), physics, safety, breast, cardiac, diagnostic radiology, gastrointestinal, genitourinary, interventional, musculoskeletal, neuroradiology, nuclear, pediatrics, thoracic, ultrasound/reproductive/endocrinology, vascular, and general radiology. Chapters are composed of four types of test cases of varying focus and complexity, each on a two-page spread. Essentials starts with a patient presentation, followed by board-type multiple-choice questions. Details begins with a case presentation, followed by 10 rapid-fire questions, enabling brisk, high-volume learning. Image Rich presents multiple images that require accurate identification, enabling accelerated, high-volume image assessment practice. More Challenging follows the same format as Essentials but adds a higher degree of difficulty. Key highlights High-quality, board-type Q&A with detailed answer explanations High yield "Top Tips" for each case Special radiology artifacts section Image Rich and Details sections aid in rapid and lasting topic mastery Comprehensive review, covering all sections tested by the American Board of Radiology Written by experienced, expert question writers NIS chapter emphasizes proficiency in vital practice-related skills This quintessential home-study guide will help radiology residents and fellows prep for and ace both the certifying and core exams.

Learn to avoid and manage complications from actual endovascular cases Complications in Vascular Interventional Therapy: Case-Based Solutions provides a systematic review of potential complications that may occur during endovascular procedures. This compendium features 106 cases from daily interventional practice that highlight the most common and important complications that can arise. Each case presents a concise account of patient history, initial treatment, problems encountered, and resulting complication; potential solutions for managing the complication; discussion and analysis of the final course of action; and valuable tips and take-home messages for complication prevention. Key Features: Covers thrombosis, arterial hemorrhage, vessel perforation, distal embolization, device malfunction, access-related complications, and much more A total of 106 real-life cases with 540 images to engage the reader and enhance problem-solving skills A wealth of information and advice for optimizing patient safety before, during, and after interventional therapy Take-home messages at the end of each case provide vital prevention strategies Further Reading and References for exploring topics of interest Complications in Vascular Interventional Therapy: Case-Based Solutions is an invaluable sourcebook for novice and experienced interventional radiologists, vascular surgeons, angiologists, and cardiologists. The clinical cases and practical details found in this book will help all physicians who perform peripheral vascular interventions prepare for the myriad complications they may encounter during endovascular procedures.

This up-to-date, superbly illustrated book is a practical guide to the effective use of neuroimaging in the patient with cognitive decline. It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate diagnosis whenever possible. After an introductory chapter on the clinical background, the available "toolbox" of structural and functional neuroimaging techniques is reviewed in detail, including CT, MRI and advanced MR techniques, SPECT and PET, and image analysis methods. The imaging findings in normal ageing are then discussed, followed by a series of chapters that carefully present and analyze the key findings in patients with dementias. Throughout, a practical approach is adopted, geared specifically to the needs of clinicians (neurologists, radiologists, psychiatrists, geriatricians) working in the field of dementia, for whom this book will prove an invaluable resource.