Proteases are everywhere from prokaryotes to eukaryotes, from
virus to bacteria and in all human tissues, playing a role in many
biological functions. Among these functions, the inflammatory
reaction is of particular interest. In inflamed tissues, proteases
can have a microbial and/or host origin and are involved not only
in tissue remodeling, but also in specific signaling to resident or
inflammatory cells, thereby contributing to the innate immune
response.
This volume presents all advances in our knowledge of the role
proteases and their inhibitors play in various diseases associated
with inflammatory response. Mechanisms involved in protease
signaling to cells are presented, and the different types of
proteases that are present at inflammatory sites and their effects
on the course of inflammation are discussed. Finally, the evidence
for considering proteases and their receptors as potential
molecular targets for therapeutic interventions in the treatment of
inflammatory diseases is discussed in the context of specific organ
inflammatory pathologies (the lung, gastrointestinal tract, skin,
joints, etc.).
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