With cardiovascular disease remaining one of the primary causes of
morbidity and mortality worldwide, there is a great need to further
understand the molecular basis of this disease class and develop
new therapeutic or preventative measures. Cardiovascular Diseases:
Nutritional and Therapeutic Interventions presents up-to-date
information on the pathobiology of cardiovascular diseases,
emphasizing emerging therapeutics and nutritional interventions.
The book is divided into four parts: epidemiology, epigenetics,
pathobiology, and therapies for cardiovascular diseases. Part I
details epidemiological studies, highlighting the extent of the
clinical problem. Part II describes the genetic and, primarily,
epigenetic modifications associated with cardiovascular disease,
including the importance of DNA methylation status and the
possibility of early intervention using simple dietary
modifications. The text also discusses histone modifications
associated with disease and potential therapeutic synthetic and
dietary compounds such as resveratrol and garlic. Covering the
etiology and pathobiology, part III discusses lipid regulation,
micro-RNAs, emerging cell-based therapies, and new receptor targets
for therapeutics as well as targeted imaging. It also describes the
link between cancer therapies and cardiomyopathy and the potential
of vitamin C to ameliorate this effect. Part IV focuses on
therapeutic and nutritional interventions, namely, stem cell
therapies, emerging nanomedicines, and a wide range of dietary
interventions. These include general healthy diets, fruits and
vegetables, botanicals, effects of specific compounds such as
antioxidants, and discussions on garlic, curcumin, and resveratrol.
The text also covers lifestyle factors, emphasizing the importance
of stress in the occurrence of and meditation and yoga in the
management of cardiovascular disease. This book provides a
comprehensive reference for clinicians and scientists, combining
epidemiology, prevention, and modern treatment strategies.
General
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