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Sex Steroids and the Cardiovascular System (Paperback, Softcover reprint of the original 1st ed. 1992)
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Sex Steroids and the Cardiovascular System (Paperback, Softcover reprint of the original 1st ed. 1992)
Series: Ernst Schering Foundation Symposium Proceedings, 5
Expected to ship within 10 - 15 working days
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Evidence accumulated over the past decade show that gonadal steroid
hormones participate in an important way in the physiological and
pa thophysiological regulation of the cardiovascular system. The
hor monal profile appears to put males at a disadvantage
biologically in terms of cardiovascular diseases. The incidence of
hypertension is higher in men than in pre-monopausal women
indicating an influence of gender on the hypertensive disease
process. Males and females have equivalent cholesterol levels until
puberty but males suffer an ex ponential increase in heart disease
in their forties, while the female rise does not start until a
decade later, after menopause. Animal and human studies provided
ample evidence, that estrogens lower the levels of low density
lipoproteins and keep high density lipoproteins elevated. These
changes may be advantageous in the prevention of heart diesease. Co
ronary artery atherosclerosis has been shown to be more pronounced
in ovarectomized female monkeys as in intact females. Androgen, con
versely, lowers the high density lipoproteins and elevates low
density lipoproteins. Regarding blood pressure, it is well
established that hypertension is more severe or develops more
rapidly in male than fe male rats in several genetic forms of
hypertension, and that gonadal steroid hormones are probably
playing an important role in explaining this observation. Risk
factors of human hypertension and coronary heart dies ease include
menopause and ovarectomy."
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