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Drug-Resistant Epilepsies (Hardcover)
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Drug-Resistant Epilepsies (Hardcover)
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Over 12 million people with epilepsy have seizures that cannot be
controlled by antiepileptic drugs. The term "drug-resistance" is
abundantly used in the epilepsy literature but the definitions
proposed differ considerably. It is used indifferently in a number
of different settings: as a criterion for selection of patients
eligible for new antiepileptic drug trials, for the selection of
surgical candidates, for the design of epidemiological studies, for
the design of studies on quality of life, for the definition of the
epileptic encephalopathies (in comparison to more benign epilepsy
syndromes), to mention but a few. As a result, available studies
are usually not comparable and referral to epilepsy specialists is
unacceptably delayed. The volume includes several focused chapters
on all issues relating to drug-resistance and offers the basis for
a consensus on a clinically meaningful core definition.
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