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Books > Medicine > Clinical & internal medicine > Gastroenterology
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Helicobacter pylori - Basic Mechanisms to Clinical Cure 2000 (Hardcover, Revised edition)
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Discovery Miles 60 130
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Helicobacter pylori - Basic Mechanisms to Clinical Cure 2000 (Hardcover, Revised edition)
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The fourth meeting in the very successful series Helicobacter
pylori: Basic Mechanisms to Clinical Cure was held on the island of
Bermuda in late March 2000 and was sponsored by Axcan Pharma. This
was only some two years after the third meeting in San Diego, and
it seemed hardly possible that there would be so much new
information. However, as the contributions in this volume testify,
there was plenty of exciting new information with important
implications for both understanding this infection and for clinical
management. Some of this information was of a fundamental nature,
such as the role of the acid sensitive ureI channel in regulating
the influx of urea and the formation of transported ammonia back in
the microbial perisplasmic space to neutralize acid; the
observation of genetic polymorphism of the IL-1beta gene as an
explanation of achlorhydria and gastric cancer risk in the
first-degree relatives of gastric cancer patients; and the peculiar
biochemical and physiological consequences of the genome of the
microorganisms. The format of the meeting, with short
fifteen-minute state-of-the-art presentations by world experts
closely involved in Helicobacter research followed by ample time
for panel discussions, was again followed this year. Traditional
aspects included detailed study of the microbial characteristics,
the novel Helicobacters, the interaction with the human host, the
peculiarities of the inflammatory immune response, the short and
long-term mucosal consequences, the effects on acid secretion, the
problem of gastric malignancy, and the therapeutic possibilities.
However, a series of short debates was introduced to highlight
controversial issues, such as the pathogenic orcommensal role of
the organism, the role of virulence factors, the characteristics of
the inflammatory immune response, the reversibility of mucosal
atrophy and metaplasia, and the primary or secondary role of
quadruple therapy, to name just a few. This provocative approach
was very successful and provided fuel for further in-depth
discussions. These debates have been included in this book in the
form of conventional manuscripts in order to maintain the shortest
possible production time for the publication of the proceedings.
Helicobacter pylori has come a long way since the first meeting in
Amelia Island, in 1993, and the science of this organism and the
understanding of the consequences of the infection have advanced
our knowledge fundamentally and revolutionized our thinking about
gastrointestinal disease. We now recognize the existence of more
than thirty Helicobacter species, some of which may play a
significant role in human disease. The experience gained through
our investigation of H. pylori promises to make a significant
contribution to the future exploration of the possible role of
Helicobacter species in hepatic, biliary, and intestinal diseases.
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