This text/reference book provides the most comprehensive coverage
of anticholinesterase compounds (Organophosphates and Carbamates),
which constitute the largest number of chemicals that are primarily
used as insecticides in agriculture, industry, and around the
home/garden. Some OPs (nerve agents) have been used in chemical
warfare and terrorist attacks, while some OPs and CMs have been
recommended as therapeutic agents in human medicine as well as in
veterinary medicine. Many chemicals of both classes are extremely
toxic and lack selectivity, thus their inadvertent/accidental use
continues to pose a threat to human and animal health, aquatic
systems and wildlife. These anticholinesterase agents produce a
variety of toxicological effects in target and nontarget organs.
In light of this complexicity, this multi-authored book is written
by the well known scientists from many countries. The book is
organized into nine sections, with a total of 49 chapters, to
provide in-depth knowledge on various aspects of OP and CM
compounds, including their use, classification, mechanism-based
toxicity, and prophylactic and therapeutic measurements. Several
chapters are written with special emphasis to cover timely topics,
such as chemical warfare agents, physiologically-based
pharmacokinetic modeling, structure and function of
cholinesterases, paraoxonase, carboxylesterases; developmental
neurotoxicity, the intermediate syndrome, oxidative stress,
endocrine disruption, and DNA damage/gene expression and
carcinogenesis. Section-VI with 5 chapters is specifically devoted
to risk assessment, and safety and regulatory guidelines for
pesticides.
-Describes everything you need to know about Organophosphates and
Carbamates
-Extensively covers pesticides, nerve agents, therapeutic drugs,
and flame retardants
-Describes epidemiology of the world's major disasters involving
Organophosphates and Carbamates
-Covers animal, human, aquatic, and wildlife toxicity of
Anticholinesterases
-Insights into in-depth cholinergic and noncholinergic mechanisms
of toxicity
-Describes recent advancements in cholinesterases, paraoxonases,
carboxylesterases, oxidative stress, endocrine disruption, cardiac
and pulmonary toxicity, and carcinogenesis
-Provides in vitro and in vivo models for neurotoxicity
testing
-Integrates knowledge of studies in lab animals and humans
-Offers risk/safety assessment and national/international
guidelines for permissible levels of pesticide residues
-Describes management of Anticholinesterase poisoning in humans
General
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