The presentation of new, emerging concepts of the pathogenesis
and management of acute Myocardial Infarction is the unprecedented
objective of this book. Based upon the Symposium on Acute MI, this
timely text presents the advances that have taken place on several
fronts in the past five years, particularly in the area related to
thrombolytic therapy. Separated into four sections, the book covers
the mechanisms of acute MI; medical problems of detection, sizing,
and damage; non-invasive medical management; and invasive
management. Of particular interest is the section on non-invasion
management which focuses on the results from the TIMI Clinical
Trial and the successful use of tissue plasminogen activator (tPA).
Focus is also placed on the long-term follow up of patients treated
with thrombolytic therapy and the no-reflow phenomenon in the
stunned myocardium. A collaboration of recognized experts in their
fields, this text is of extreme value to the practicing
cardiologist, radiologist, surgeon and emergency care
physician.
The text's first section explores the basic mechanisms of
coronary artery contraction, coronary artery stenosis and vasopasm.
Its second section develops the pathophysiology of acute MI
including the reversibility of ischemic myocardial injury, and
methods for detecting the size and extent of myocardial infarcts.
The crucial role of cardiac muscle cell membrane damage is also
discussed. The physiology and pharmacology of tPA are described in
the third section as are the results from the initial phase 1 TIMI
trial. The final section which concentrates on surgical procedures,
also provides future directions for the diagnosis and treatment of
acute Myocardial Infarctions.
General
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