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Oxidative Stress and Redox Signalling in Parkinson's Disease (Hardcover)
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Oxidative Stress and Redox Signalling in Parkinson's Disease (Hardcover)
Series: Issues in Toxicology, Volume 34
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Parkinson's Disease is the second most common neurodegenerative
disorder affecting millions of people worldwide. In order to find
neuroprotective strategies, a clear understanding of the mechanisms
involved in the dopaminergic death of cells that progresses the
disease is needed. Oxidative stress can be defined as an imbalance
between the production of reactive species and the ability to
detoxify them and their intermediates or by-products. Oxidative
damage to lipids, proteins, and DNA has been detected in autopsies
from individuals with Parkinson's Disease and so links can be made
between oxidative stress and Parkinson's Disease pathogenesis. This
book provides a thorough review of the mechanisms by which
oxidative stress and redox signalling mediate Parkinson's Disease.
Opening chapters bring readers up to speed on basic knowledge
regarding oxidative stress and redox signalling, Parkinson's
Disease, and neurodegeneration before the latest advances in this
field are explored in detail. Topics covered in the following
chapters include the role of mitochondria, dopamine metabolism,
metal homeostasis, inflammation, DNA-damage and thiol-signalling.
The role of genetics and gene-environment interactions are also
explored before final chapters discuss the identification of
potential biomarkers for diagnosis and disease progression and the
future of redox/antioxidant based therapeutics. Written by
recognized experts in the field, this book will be a valuable
source of information for postgraduate students and academics,
clinicians, toxicologists and risk assessment groups. Importantly,
it presents the current research that might later lead to redox or
antioxidant - based therapeutics for Parkinson's disease.
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