Autoimmune disorders are amongst the most frequently encountered
conditions in endocrine practice. The evidence-based approach to
therapeutics and detailed evaluation of the outcome of existing
treatment regimens have led to some advances in care delivery.
Pragmatic reviews by leading international experts outline the
clinical state of the art in several chapters of this issue of the
Endocrinology and Metabolism Clinics of North America devoted to
autoimmune disorders. Topics covered include the following:
regulatory T cells as key players in tolerance and autoimmunity;
immunology lessons from monogenic conditions such as AIRE;
immunogenetics of T1D and AITD; advances in T1D therapeutics,
including islet cell replacement and salvage; updates on TSHR
structure, function, and monoclonal human TSHR antibodies; animal
models of Grave's disease; evidence-based and emerging modalities
of treatment of Graves' hyperthyroidism; patient selection and
treatment of thyroid-associated ophthalmopathy; antibodies to
steroidogenic tissues: Addison's and POF; diagnosis and management
of polyendocrinopathy syndromes; autoimmune parathyroid disease;
and autoimmune hypophysitis.
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