Systems Chemical Biology - Methods and Protocols (Hardcover, 1st ed. 2019)

This volume explores the latest available wet-lab techniques and computational methods to study in-cell small-molecule behavior and interactions with their targets. The chapters in this book discuss topics such as disease-relevant models for chemical biology studies, target engagement using cellular thermal shift assay or bioluminescence resonance energy transfer; visualization of bio-active small molecules Raman microscopy; (phospho-)proteomics and transcriptomics for mode-of-action studies, CRISPR/Cas9-based chemogenomic profiling in mammalian cells; predicting drug interactions using computational approaches; comparison of compound-induced profiles using high-content imaging or cancer cell line panels and web-based tools for polypharmacology prediction. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Systems Chemical Biology: Methods and Protocols is a valuable resource for novice or expert scientists and researchers trying to initiate or continue their chemical biology studies at a systems level.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 1888
Release date:	December 2018
First published:	2019
Editors:	Slava Ziegler • Herbert Waldmann
Dimensions:	254 x 178 x 22mm (L x W x T)
Format:	Hardcover
Pages:	315
Edition:	1st ed. 2019
ISBN-13:	978-1-4939-8890-7
Categories:	Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Computing & IT > General theory of computing > General Promotions
LSN:	1-4939-8890-5
Barcode:	9781493988907

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