One approach to organic synthesis is retrosynthetic analysis. With
this approach chemists start with the structures of their target
molecules and progressively cut bonds to create simpler molecules.
Reversing this process gives a synthetic route to the target
molecule from simpler starting materials. This "disconnection"
approach to synthesis is now a fundamental part of every organic
synthesis course.
Workbook for Organic Synthesis: The Disconnection Approach, 2nd
Edition
This workbook provides a comprehensive graded set of problems to
illustrate and develop the themes of each of the chapters in the
textbook "Organic Synthesis: The Disconnection Approach, 2nd
Edition." Each problem is followed by a fully explained solution
and discussion. The examples extend the student's experience of the
types of molecules being synthesised by organic chemists, and the
strategies they employ to control their syntheses. By working
through these examples students will develop their skills in
analysing synthetic challenges, and build a toolkit of strategies
for planning new syntheses. Examples are drawn from
pharmaceuticals, agrochemicals, natural products, pheromones,
perfumery and flavouring compounds, dyestuffs, monomers, and
intermediates used in more advanced synthetic work. Reasons for
wishing to synthesise each compound are given. Together the
workbook and textbook provide a complete course in retrosynthetic
analysis.
Organic Synthesis: The Disconnection Approach, 2nd Edition
There are forty chapters in "Organic Synthesis: The
Disconnection Approach, 2nd Edition" those on the synthesis of
given types of molecules alternate with strategy chapters in which
the methods just learnt are placed in a wider context. The
synthesis chapters cover many ways of making each type of molecule
starting with simple aromatic and aliphatic compounds with one
functional group and progressing to molecules with many functional
groups. The strategy chapters cover questions of selectivity,
protection, stereochemistry, and develop more advanced thinking via
reagents specifically designed for difficult problems. In its
second edition updated examples and techniques are included and
illustrated additional material has been added to take the student
to the level required by the sequel, "Organic Synthesis: Strategy
and Control." Several chapters contain extensive new material based
on courses that the authors give to chemists in the pharmaceutical
industry.
"Workbook for Organic Synthesis: The Disconnection Approach, 2nd
edition," combined with the main textbook, provides a full course
in retrosynthetic analysis for chemistry and biochemistry students,
and a refresher course for organic chemists working in industry and
academia.
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