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The Genetics of Complex Thyroid Diseases (Paperback, Softcover reprint of the original 1st ed. 2002)
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The Genetics of Complex Thyroid Diseases (Paperback, Softcover reprint of the original 1st ed. 2002)
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The rapid developments in molecular genetics have clarified many of
the muta tions in monogenic thyroid diseases over the last two
decades; now the target of molecular thyroid genetics has become
the oligogenic thyroid diseases. These include the autoimmune
thyroid diseases and familial thyroid cancers, both of which are
much commoner than the monogenic diseases. However, the method
ological approach to the genetics of these more complex diseases is
still far from being well established. Although the discovery of
susceptibility genes has been partially accomplished in complex
diseases such as asthma, Crohn's dis ease, and types I and II
diabetes mellitus, the elucidation of susceptibility genes in
complex diseases remains a major challenge. This volume contains
papers presented at the International Symposium on the Genetics of
Complex Thyroid Diseases. This meeting was held in association with
the International Thyroid Congress in Kyoto in October 2000 and sup
ported in part by the Japan Intractable Diseases Research
Foundation and Knoll Pharmaceuticals Inc. The symposium was the
first international symposium con cerning the genetics of complex
thyroid diseases and was restricted to the study of the autoimmune
thyroid diseases and familial thyroid cancer. Twenty distin guished
researchers from the United States, the United Kingdom, France, Ger
many, Italy, and Japan were invited. Each presentation precipitated
intense dis cussion and there was much consensus during the
meeting. Nevertheless, this volume will leave the reader with a
clear understanding of how little we still know.
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