Thresholds of Genotoxic Carcinogens - From Mechanisms to Regulation (Hardcover)

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.

General

Imprint:	Academic Press Inc
Country of origin:	United States
Release date:	May 2016
First published:	2016
Editors:	Takehiko Nohmi • Shoji Fukushima
Dimensions:	235 x 191 x 17mm (L x W x T)
Format:	Hardcover - Cloth over boards
Pages:	224
ISBN-13:	978-0-12-801663-3
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology Books > Science & Mathematics > Biology, life sciences > Biochemistry > Toxicology (non-medical)
LSN:	0-12-801663-9
Barcode:	9780128016633

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