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The Dynamic Body Tissues - An account of the chalone mechanisms and other influences that control the epidermis and the various body tissues, and of the failure of these mechanisms in cancer (Paperback, Softcover reprint of the original 1st ed. 1983)
Loot Price: R1,509
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The Dynamic Body Tissues - An account of the chalone mechanisms and other influences that control the epidermis and the various body tissues, and of the failure of these mechanisms in cancer (Paperback, Softcover reprint of the original 1st ed. 1983)
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The study of life is the study of tier upon tier of interlocking
homeostatic mechanisms, and the main theme of this book concerns
that part of the system that ensures cellular and tissue
homeostasis and thus maintains tissue mass, tissue structure and
tissue function in the adult mammal. The functional existence of
any adult tissue depends on the continuing control of the states of
differentiation of its cells. Just as in an embryo, where cellular
differentiation is initiated and controlled by the genetic
responses of the cells to specific messenger molecules, so also
throughout the whole of adult life does the genetic activity of the
tissue cells continue to be regulated by similarly specific
messenger molecules. The process of differentiation does not cease
in the embryo but remains as the essential factor which ensures not
only the function but also the continuing existence of the adult
tissues. Thus the first problem considered here, the methods of
control of cell production, cell function and cell death, is
discussed in terms of the nature and mode of action of those
messenger molecules which, from moment to moment, determine the
states of differentiation of the tissue cells. Some of these
messenger molecules are synthesized in adjacent tissues while
others are synthesized within the responding tissues themselves.
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