Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
|
Buy Now
The Renin-Angiotensin System and the Kidney - New Insights and Perspectives (Paperback)
Loot Price: R895
Discovery Miles 8 950
|
|
The Renin-Angiotensin System and the Kidney - New Insights and Perspectives (Paperback)
Series: Colloquium Series on Integrated Systems Physiology: From Molecule to Function
Expected to ship within 10 - 15 working days
|
The renin-angiotensin system (RAS) is one of the most important
endocrine (tissue-to-tissue), paracrine (cell-to-cell) and
intracrine (intracellular/nuclear) humoral systems in the
regulation of blood pressure, cardiovascular, and kidney function
in health and disease. The RAS has remarkably evolved from the
initial discovery of the rate-limiting enzyme renin to a complex
biochemical and physiological cascade involving more than a dozen
members. Currently, there are up to five axes or pathways
identified in the RAS; each has its substrate, enzyme, effector
peptide, receptor, and downstream signaling pathways. These include
the renin/ACE/ANG II/AT1 receptor, the APA/ANG III/AT2 receptor,
the ACE2/ANG (1-7)/Mas receptor, the prorenin/prorenin receptor
(PRR), and the ANG IV/AT4 receptor (IRAP) pathways. Accordingly,
the roles of the RAS have expanded well beyond the classic
endocrine paradigm as a powerful vasoconstrictor, a potent
aldosterone stimulator, or a sodium-retaining hormonal system. The
goals of this article are to review and discuss the current
insights into and new perspectives on the expression, localization,
and novel actions of the RAS with a focus in the kidney. Special
emphasis will be placed on recently discovered new members of the
RAS derived from studies using innovative mutant rats or mice that
either overexpress (knockin) or are deficient (knockout) of a
particular substrate, enzyme, ANG peptide, or receptor. This new
knowledge will help improve our understanding how each of these
pathways act directly or indirectly to regulate blood pressure,
cardiovascular and kidney function in physiology, and can be
targeted to treat hypertension, cardiovascular and renal diseases.
General
Imprint: |
Morgan & Claypool Publishers
|
Country of origin: |
United States |
Series: |
Colloquium Series on Integrated Systems Physiology: From Molecule to Function |
Release date: |
March 2015 |
Authors: |
Xiao C Li
• Jia L Zhuo
|
Dimensions: |
235 x 191 x 6mm (L x W x T) |
Format: |
Paperback
|
Pages: |
61 |
ISBN-13: |
978-1-61504-674-4 |
Categories: |
Books >
Medicine >
Pre-clinical medicine: basic sciences >
Physiology >
General
|
LSN: |
1-61504-674-7 |
Barcode: |
9781615046744 |
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
You might also like..
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.