Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.

This collective compendium highlights the achievements of Soviet and Russian mathematical and computer science scientific schools in the area of image analysis and understanding, pattern recognition, artificial intelligence and adjacent fields of computer sciences and applied mathematics.Contributed by renowned researchers, the materials collated are original papers never published before. This chapters provide good balance between fundamental and applied statements of problems and results.This unique reference text benefits professionals, researchers, academics, and graduate students in pattern recognition/image analysis, theoretical computer science and AI.

The Tosefta is an ancient Jewish legal text that comprises a second compilation of the Oral law. This edition of the Tosefta, Tractate Berachot, is the first of its kind with an introduction, the edited Hebrew text based on ancient manuscripts, an English translation, and a comprehensive commentary in English. The author and translator, Eliyahu Gurevich, is an American-Israeli scholar, and creator of seforimonline.org and toseftaonline.org.

How do you protect electrical systems from high energy electromagnetic pulses? This book is designed for researchers who wish to design toughned systems against EMPs from high altitude sources. It discusses numerous factors affecting the strength of EMPs as well as their impact on electronic components, devices and power electrical equipment. This book includes practical protection methods and means for evaluating their effectiveness.

This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Theoretical advances in dynamical-systems theory and their applications to pattern-forming processes in the sciences and engineering are discussed in this volume that resulted from the conference Patterns in Dynamics held in honor of Bernold Fiedler, in Berlin, July 25-29, 2016.The contributions build and develop mathematical techniques, and use mathematical approaches for prediction and control of complex systems. The underlying mathematical theories help extract structures from experimental observations and, conversely, shed light on the formation, dynamics, and control of spatio-temporal patterns in applications. Theoretical areas covered include geometric analysis, spatial dynamics, spectral theory, traveling-wave theory, and topological data analysis; also discussed are their applications to chemotaxis, self-organization at interfaces, neuroscience, and transport processes.

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

The development of modern Europe, through such events as the Reformation and Counter-Reformation, the Enlightenment, the French Revolution, and the rise of industrial capitalism, is often seen in terms of the triumph of individualism. Yet the precise stages in the evolution of the European individual remain one of the most elusive aspects of the region's history. In this broad and thought-provoking investigation, Aaron Gurevich, one of Russia's leading historians, examines the growth of individual consciousness through European history, and assesses its impact on key social and political events.Traditional interpretations locate the rise of the self-aware, autonomous European citizen in the Italian Renaissance of the late fourteenth and fifteenth centuries. However, as Aaron Gurevich argues, the origins of the movements can, in fact, be traced to the early Middle Ages. Drawing from a wide range of cultural sources, from Scandinavian sagas to the poetry of Dante and Petrarch, and from sermons and religious painting to the autobiographical works of writers such as Pierre Abelard and Bernard of Clairvaux, the author charts the transition from earlier forms of community life, characterized by local, kinship groups and collective identity, towards a changed, universal society dominated by the cognitive, motivational individual. Throughout the book intellectual and cultural trends are linked to economic realities, where social mobility, labor markets and developing economies are explained and understood in their broadest context.This is a bold and thought-provoking volume which will be welcomed by all those interested in Europe's intellectual and cultural inheritance.

Event Studies are overwhelmingly widespread in financial research, providing tools for shedding light on market efficiency, as well as measuring the impact of various occurrences on public firms' security prices. Mastering the Event Study approach is essential for researchers and practitioners alike. Event Studies for Financial Research aims to help readers obtain valuable hands-on experience with Event Study tools and gain technical skills for conducting their own studies. Kliger and Gurevich provide a detailed application of their approach, which consists of: a description of the method; references; guided applications; and elaborated framework for implementing the applications.

How do you protect electrical systems from high energy electromagnetic pulses? This book completes the overview of systems and practices against EMPs from high altitude sources started with the previous "Protecting Electrical Equipment - Good Practices for preventing high altitude electromagnetic pulse impacts", including practical protection methods and means for evaluating their effectiveness.

*Provides a foundational understanding of linguistics as it applies to spoken and signed languages. *Covers numerous linguistic disciplines such as phonetics, semantics and sociolinguistics. *Makes linguistic theory accessible to speech-language pathologists. *Highlights the importance of integrating linguistic frameworks into clinical decision-making.

*Provides a foundational understanding of linguistics as it applies to spoken and signed languages. *Covers numerous linguistic disciplines such as phonetics, semantics and sociolinguistics. *Makes linguistic theory accessible to speech-language pathologists. *Highlights the importance of integrating linguistic frameworks into clinical decision-making.

The Palestine Exploration Fund (PEF) is the oldest exploration society of the Levant which is active today. Since its founding meeting in 1865 in Westminster Abbey of London, the PEF scholars have conducted systematic exploration of Jerusalem and the Holy Land. Prominent archaeologists such as C.W. Wilson, C. Warren, C. Schick, C. Conder, W.M.F Petrie, H. Kitchener, and R.A.S Macalister, were sent to dig the Holy Land on behalf of the PEF. A remarkable enterprise carried out by the PEF, in cooperation with the Royal Engineers, was the first precise scientific survey of the region - The Survey of the Western Palestine - which yielded the pioneering high-quality detailed maps of the Holy Land. Marking the 150 years since the PEF emerged, the studies collected in this volume provide a retrospective on the endeavours in the light of the findings of the contemporary archaeological research.

Digital (microprocessor-based) protection relays (DPR) are dominating the global market today, essentially pushing all other types of relays out of the picture. These devices play a vital role in power operations for fields ranging from manufacturing, transportation, and communication to banking and healthcare. Digital Protective Relays: Problems and Solutions offers a unique focus on the problems and disadvantages associated with their use, a crucial aspect that goes largely unexamined. While there is already a massive amount of literature documenting the benefits of using digital relays, devices as sophisticated as DPR obviously have faults and drawbacks that need to be understood. This book covers these, delving into the less familiar inner workings of DPR to fill a critical literary void and help decision makers and specialists in the field of protection relays find their way out of the informational vacuum. The book provides vital information to assist them in evaluating relay producers' claims and then choose the right product. Tearing away the informational "curtain" that exists today, this book: Describes construction of functional modules of existing relays Analyzes drawbacks and problems of digital relays Details specific technical problems and their solutions Assesses dangers of intentional destructive electromagnetic intrusions Discusses alternative (non-microprocessor-based) protection relays, and problems related to international standards Focusing on practical solutions, this book explains how to correctly choose digital relays and ensure their proper use while avoiding the many problems they can present. The author avoids mathematics and theory in favor of more practical, tangible information not easily found elsewhere. Setting itself apart from other books on the subject, this volume shines a light into the long hidden "black box" of information

Gina loves playing soccer, and she can't wait to join the team at her new school. But when Gina tries to be the star of the team, her new teammates don't exactly appreciate it. Gina has to learn that teamwork is more important than winning before she can get back on the field.

This book analyzes 153 languages from a large variety of families to establish a previously unexplored relationship between phonetically conditioned sound changes such as lenitions and functional (meaning maintenance related) considerations. Carefully collecting numerous inventories of consonants, this collection is likely to become an important resource for future linguistics research. By distinguishing between phonetic and phonological neutralization, and showing that the first does not necessarily result in the second, Naomi Gurevich uncovers previously unexplored and often surprising trends in the relationship between phonetics and phonology.

Digital (microprocessor-based) protection relays (DPR) are dominating the global market today, essentially pushing all other types of relays out of the picture. These devices play a vital role in power operations for fields ranging from manufacturing, transportation, and communication to banking and healthcare.

Digital Protective Relays: Problems and Solutions offers a unique focus on the problems and disadvantages associated with their use, a crucial aspect that goes largely unexamined. While there is already a massive amount of literature documenting the benefits of using digital relays, devices as sophisticated as DPR obviously have faults and drawbacks that need to be understood. This book covers these, delving into the less familiar inner workings of DPR to fill a critical literary void and help decision makers and specialists in the field of protection relays find their way out of the informational vacuum. The book provides vital information to assist them in evaluating relay producers' claims and then choose the right product.

Tearing away the informational "curtain" that exists today, this book:

• Describes construction of functional modules of existing relays
• Analyzes drawbacks and problems of digital relays
• Details specific technical problems and their solutions
• Assesses dangers of intentional destructive electromagnetic intrusions
• Discusses alternative (non-microprocessor-based) protection relays, and problems related to international standards

Focusing on practical solutions, this book explains how to correctly choose digital relays and ensure their proper use while avoiding the many problems they can present. The author avoids mathematics and theory in favor of more practical, tangible information not easily found elsewhere. Setting itself apart from other books on the subject, this volume shines a light into the long hidden "black box" of information on DPRs, giving users a valuable tool to help them anticipate possible problems, something sorely lacking in the literature.

This book analyzes 153 languages from a large variety of families to establish a previously unexplored relationship between phonetically conditioned sound changes such as lenitions and functional (meaning maintenance related) considerations. Carefully collecting numerous inventories of consonants, this collection is likely to become an important resource for future linguistics research. By distinguishing between phonetic and phonological neutralization, and showing that the first does not necessarily result in the second, Naomi Gurevich uncovers previously unexplored and often surprising trends in the relationship between phonetics and phonology.

This publication discusses general problems related to the structure of current overload protection systems in high voltage (HV) electrical installations and introduces a family of new devices based on reed switch contacts, solid-state units, hybrid technology and automatic systems based on these components. It highlights their application in high voltage (5 to 100 kV) power supplies, power lasers and radar, RF-generators and protection systems for class 6 to 24 kV distribution networks. The author also discusses applications in power engineering, radio-electronic equipment, and industrial high voltage devices.

A comprehensive and unique account of the creation of artificially ionized layers in the middle and upper atmosphere, using powerful radio waves. Major physical mechanisms associated with the formation of the ionized region are studied in detail. The main part of the author's research is devoted to problems associated with the breakdown mechanisms for radio frequency discharges in air. A special chapter deals with breakdown in intersecting pulsed beams and the effects of recombination, diffusion and atmospheric winds on the stability of the structure. The kinetics of the plasma produced are also described.
The authors examine possibilities of inducing changes in the chemical composition of the upper atmosphere by means of radio frequence heating, with promising effects on the concentration of constituents such as ozone. The feasibility of using this phenomenon for; ozone healing - in connection with the ozone holes in the polar regions is investigated. The text is a timely treatment of key topics in the field of ionospheric modification.