This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the 'disease-related' chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where 'modern' technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.

"If I'm not going to kill myself, then I might as well do something with my life. After all, it is mine. Come to think of it, it's the only thing I have. After all the things I've lost, I cannot lose one more." The Road to Hell and Back will Demonstrate it is possible to overcome depression. Show you how to improve now. Give you practical techniques to use today. Are you: Desperate and don't know where to turn? (page 2) Ready to move on? (page 18) Looking for a doctor? (page 35)