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Handbook of Contemporary Developments in World Ecology (Hardcover): Edward Kormandy, J.Frank McCormick Handbook of Contemporary Developments in World Ecology (Hardcover)
Edward Kormandy, J.Frank McCormick
R2,602 Discovery Miles 26 020 Ships in 10 - 15 working days

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Protein Tyrosine Kinases - From Inhibitors to Useful Drugs (Hardcover, 2006 ed.): Doriano Fabbro, Frank McCormick Protein Tyrosine Kinases - From Inhibitors to Useful Drugs (Hardcover, 2006 ed.)
Doriano Fabbro, Frank McCormick
R5,608 Discovery Miles 56 080 Ships in 10 - 15 working days

Leading researchers, from the Novartis group that pioneered Gleevec/Gliveca"[ and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.

Ras and Cancer in the 21st Century (Hardcover): Linda Vanaelst, Julian Downward, Frank McCormick Ras and Cancer in the 21st Century (Hardcover)
Linda Vanaelst, Julian Downward, Frank McCormick
R2,627 Discovery Miles 26 270 Ships in 12 - 19 working days
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