As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant decrease in a 3 hydroxyl ion. Globally, the functions of the carbonic anhydrases in photosynthesis in rain forests and in the algae and plankton that cover our oceans indicate that they are also of utmost importance in the maintenance of the acid-base balance on our planet. Although the whole field of C0 metabolism is enormous and still rapidly 2 expanding, because of the research interests of the editors this book is mainly concerned with mammalian carbonic anhydrases. However, if the interested reader intends to purify carbonic anhydrases from nonmammalian sources, Dr. Cheg widden has provided the necessary information in Chapter 7. The carbonic anhydrases were first discovered in 1933; until1976 there were thought to be only two isozymes. Since then CA ill, IY, V, VI, and Vll have been discovered and well characterized. There is, of course, no reason to believe that we have found them all."

As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant decrease in a 3 hydroxyl ion. Globally, the functions of the carbonic anhydrases in photosynthesis in rain forests and in the algae and plankton that cover our oceans indicate that they are also of utmost importance in the maintenance of the acid-base balance on our planet. Although the whole field of C0 metabolism is enormous and still rapidly 2 expanding, because of the research interests of the editors this book is mainly concerned with mammalian carbonic anhydrases. However, if the interested reader intends to purify carbonic anhydrases from nonmammalian sources, Dr. Cheg widden has provided the necessary information in Chapter 7. The carbonic anhydrases were first discovered in 1933; until1976 there were thought to be only two isozymes. Since then CA ill, IY, V, VI, and Vll have been discovered and well characterized. There is, of course, no reason to believe that we have found them all."

This volume contains the papers presented at the symposium on Biophysics and Physiology of Carbon Dioxide held at Regensburg, April 17-20, 1979. The manuscripts represent the full or even an extended account of the oral presentations. We have decided not to include any part of the discussions which took place after the lectures because this would have led to an undue enlargement of the already substantial volume. The symposium brought together some 60 scientists of various disciplines including biophysicists, chemists, biochemists, physiologists, pharmacologists, as well as clinicians whose research activities are cen tered around the various aspects of the reactions and the regulatory role of CO within the body. 2 In view of the fact that numerous textbooks and Proceedings of Symposia deal expertly with the role of CO in acid-base balance, it 2 was decided not to include this aspect in the present symposium. This holds also for the biochemistry of carboxylation and decarboxylation reactions. Particular emphasis was placed on the following subjects: (1) Chemical reactions of CO in water and facilitated diffusion of CO2, 2 (2) CO adducts to proteins, in particular hemoglobin, and peptide 2 hormones, (3) structure and function of carbonic anhydrase, (4) CO 2 exchange and carbonic anhydrase activity in respiratory and nonrespi ratory systems. Each section contains at least one introductory paper that presents the current knowledge in a more general framework."

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ De La Generation Spontanee Ou Primitive En General Et En Particulier Des Helminthes: Extrait Du Bull. De La Soc. Imp. Des Natural. De Moscow 20. 1847 G. Gros