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The Carbonic Anhydrases - Cellular Physiology and Molecular Genetics (Hardcover, 1991 ed.)
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The Carbonic Anhydrases - Cellular Physiology and Molecular Genetics (Hardcover, 1991 ed.)
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As we approach the twenty-first century the problems of
industrialization are evident: we find there is a greenhouse
effect, the ozone layer is being depleted, the rain is acidified,
and there is a terrible problem of increasing C0 concentrations in
the atmo 2 sphere. The carbonic anhydrases are a unique family of
enzymes that solve these problems in the human body: they are
responsible for converting C0 (a gas) to 2 HC0-, which is the
biggest intracellular buffer, with a concomitant decrease in a 3
hydroxyl ion. Globally, the functions of the carbonic anhydrases in
photosynthesis in rain forests and in the algae and plankton that
cover our oceans indicate that they are also of utmost importance
in the maintenance of the acid-base balance on our planet. Although
the whole field of C0 metabolism is enormous and still rapidly 2
expanding, because of the research interests of the editors this
book is mainly concerned with mammalian carbonic anhydrases.
However, if the interested reader intends to purify carbonic
anhydrases from nonmammalian sources, Dr. Cheg widden has provided
the necessary information in Chapter 7. The carbonic anhydrases
were first discovered in 1933; until1976 there were thought to be
only two isozymes. Since then CA ill, IY, V, VI, and Vll have been
discovered and well characterized. There is, of course, no reason
to believe that we have found them all."
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