Avian Influenza has become one of the biggest threats for human and animal health. The old paradigm was that the disease in waterfowl, poultry, pigs and man was caused by separate viruses that each stayed reasonably well within their own niche. The only danger to man was considered being infected by pigs, being the mixing vessel, where avian and human influenza viruses could come together and exchange genetic material to form new viruses that are potentially dangerous to man.

This has dramatically proven wrong during the last decade, with huge outbreaks in the USA, Europe, and Asia. The H5N1 strain that caused human deaths in Hong Kong appeared to be transmitted directly from poultry to man. This initiated sudden awareness that pigs were not a necessary intermediate in the transmission chain. During the AI outbreaks in Italy, mutation of low-pathogenicity viruses into high-pathogenicity viruses in poultry appeared another new threat, and further evidence that the poultry sector had a wolf in sheepa (TM)s clothing. It put pressure on development of diagnostic methods that could be used in large monitoring programmes.

In The Netherlands a human fatality, after increased reports of conjunctivitis during a H7N7 outbreak, signalled that different AI strains could be fatal to man. Also, the huge economic losses and difficulties in controlling the spread of the infection in densely populated poultry areas, problems with vaccination and lack of marker vaccines demonstrated that the current control policy must be improved. These events led to an international AI conference with experts from Asia, USA and Europe.

In this book you will find new views on the issues, expert opinions andthe results of in-depth discussions among avian experts of around the world that do not want to give up against this dangerous virus.

Years ago when we were asked to write a book on the present-day knowledge of the molecular biology of poliovirus, we did not expect that such an apparently simple task could involve so much time and effort. Our writing was hampered by the fact that both of us are full time "workers," so that this monograph is mainly a spare time expedience. The main attention of this book focuses on a detailed review of the molecular biology of poliovirus and especially on the advances of the last decade; medical and environmental aspects are only briefly mentioned. Observations from older studies are considered in view of more recent information. Some of the older ob servations provided fundamental insights and paved the way for present day research; too often such data has been neglected or independently rediscovered. Today, poliovirus research has again attracted considerable interest. High points gained within the last few years were the elucidation of the complete nucleotide sequences of the RNAs of the three poliovinls serotypes and the corresponding vaccine strains, the demonstration of genome evolution during transmission of poliovirus in an epidemic, further characterization of the antigenic sites on the virus particle and of the antigenic drift, characterization of alternate conforma tional states of the virion capsid, the development of monoclonal antibodies against some of the virus proteins, observations on the role of the plasma membrane, cytoskeleton, and cytoplasmic membranes as mediators in the virus induced redirection of the synthetic machinery of the host cell, and characteriza"

A NEW YORK TIMES BESTSELLERKoch Industries is one of the largest private companies in the world with an estimated worth of $100 billion. But what makes this company so profitable? You won't find its name on the connectors in your smartphone or your baby's ultra-absorbent nappies, but Koch makes these and many other innovations, driven by its Market-Based Management (R) system for generating good profit.Good profit results from products and services that improve people's lives. It results from a culture where employees are empowered to be entrepreneurial and customer-focused.Drawing on stories from his nearly six decades in business, Charles Koch shows how any company, industry or organisation can:* Thrive in spite of disruption and changing consumer values* Create accountability with ownership and decision rights for employees based on their comparative advantages and contributions, not job title* Foster a culture of knowledge-sharing that rejects bureaucracy and hierarchy* Offer employees compensation limited only by the value they create - not budgets or policyA must-read for leaders, entrepreneurs, students and anyone who wants a more civil, fair and prosperous society, Good Profit is destined to rank as one of the greatest management books of all time.'This book helps show you the way to good profit - whether you work for an international supermarket chain, a medium-sized regional business, or your own start-up' John Mackey, Co-Founder and Co-CEO Whole Foods Market

Here is another contribution in the continuing series on Computer Methods in the Geosciences. As its title suggests, this volume will be of interest to explorational geochemists who want to analyze their own data on a personal computer (PC). To make it easy for the user, the programs and two trial data sets are provided on the accompanying diskettes. And, by supplying the diskettes, another first is accom plished for the series: instant involvement and interaction for the user. Although other books in the series have provided listings of computer pro grams, Exploration-Geochemical Data Analysis with the IBM PC is the first to supply diskettes. The diskettes, along with the instructions outlined in the text, eliminate the bother (and errors) of pu tting the programs in man ually. The suite of programs for handling and sorting data files; computing and displaying summary statistics; and working with logarithms, geochemical thresholds, and regression - will give geochemists a good repertoire for geochemical exploration data analysis. The diskettes are easy to use and have been tested thoroughly."

Avian Influenza has become one of the biggest threats for human and animal health. The old paradigm was that the disease in waterfowl, poultry, pigs and man was caused by separate viruses that each stayed reasonably well within their own niche. The only danger to man was considered being infected by pigs, being the mixing vessel, where avian and human influenza viruses could come together and exchange genetic material to form new viruses that are potentially dangerous to man.

This has dramatically proven wrong during the last decade, with huge outbreaks in the USA, Europe, and Asia. The H5N1 strain that caused human deaths in Hong Kong appeared to be transmitted directly from poultry to man. This initiated sudden awareness that pigs were not a necessary intermediate in the transmission chain. During the AI outbreaks in Italy, mutation of low-pathogenicity viruses into high-pathogenicity viruses in poultry appeared another new threat, and further evidence that the poultry sector had a wolf in sheepa (TM)s clothing. It put pressure on development of diagnostic methods that could be used in large monitoring programmes.

In The Netherlands a human fatality, after increased reports of conjunctivitis during a H7N7 outbreak, signalled that different AI strains could be fatal to man. Also, the huge economic losses and difficulties in controlling the spread of the infection in densely populated poultry areas, problems with vaccination and lack of marker vaccines demonstrated that the current control policy must be improved. These events led to an international AI conference with experts from Asia, USA and Europe.

In this book you will find new views on the issues, expert opinions andthe results of in-depth discussions among avian experts of around the world that do not want to give up against this dangerous virus.

Pediatric Dentistry: A Clinical Approach, Third Edition provides a uniquely clear, comprehensive, and clinical approach to the dental treatment of children and adolescents. * Offers systematic coverage of all clinical, scientific and social topics relating to pediatric dentistry * Thoroughly revised and updated new edition, with an increased focus on evidence based care * Includes three new chapters on genetics, child abuse and neglected children, and ethics * Pedodontic endodontics is now covered by two chapters one on primary teeth and one on young permanent teeth * Features a companion website with interactive self-assessment questions

This volume collects the contributions presented at the "Working Conference on System Theory in Immunology," held in Rome, May 1978. The aim of the Conference was to bring together immunologists on one side and experts in system theory and applied mathematics on the other, in order to identify problems of common interest and to establish a network of joint effort toward their solution. The methodologies of system theory for processing experimental data and for describing dynamical phenomena could indeed contribute significantly to the under standing of basic immunological facts. Conversely, the complexity of experimental results and of interpretative models should stimulate mathematicians to formulate new problems and to design appropriate procedures of analysis. The multitude of scientific publications in theoretical biology, appeared in recent years, confirms this trend and calls for extensive interaction between mat- matics and immunology. The material of this volume is divided into five sections, along the scheme of the Conference program."

In 1961, Charles Koch joined his father’s Wichita-based company, then valued at $21 million. Six years later, he was named chairman of the board and CEO of Koch Industries, Inc. Today, Koch Industries’ estimated worth is $100 billion -- making it one of the largest private companies in the world. Koch exceeds the S&P 500’s five-decade growth by 27-fold and plans to double its value on average every six years. What exactly does this company do and why is it so remarkably profitable? Koch’s name may not be on your stain-resistant carpet, stretch denim jeans, the connectors in your smart phone, or your baby’s ultra-absorbent diapers but it makes them all. And Koch’s Market-Based Management system is what drives these innovations and many more. Based on five decades of interdisciplinary studies, experimental discovery, and practical implementation across Koch businesses worldwide, the core objective of MBM is to generate good profit. Good profit results from products and services that customers vote for freely with their dollars, products that improve people’s lives. It results from a culture where employees are empowered to act entrepreneurially to discover customers’ preferences and the best ways to satisfy them. Good profit is what follows when long-term value is created for customers, employees, shareholders, and society. Here, drawing on revealing, honest, and previously untold stories from his nearly six decades in business, Koch walks the reader through the five dimensions of MBM to show how to apply its framework to generate more good profit in any business, industry, or organization of any size. Readers will learn how to:

• Craft a vision for how to thrive in spite of increasingly rapid disruption
• Select and retain a workforce possessing both virtue and talent
• Create an environment of knowledge sharing that prizes respectful challenges from everyone at every level
• Award employees with ownership and decision rights based on their proven contributions, not job title
• Motivate all employees to maximize their contributions by structuring incentives so compensation is limited only by the value they create

A must-read for any leader, entrepreneur, or student, as well as anyone who wants a more civil, fair, and prosperous society, Good Profit is destined to rank as one of the greatest management books of all time.

Years ago when we were asked to write a book on the present-day knowledge of the molecular biology of poliovirus, we did not expect that such an apparently simple task could involve so much time and effort. Our writing was hampered by the fact that both of us are full time "workers," so that this monograph is mainly a spare time expedience. The main attention of this book focuses on a detailed review of the molecular biology of poliovirus and especially on the advances of the last decade; medical and environmental aspects are only briefly mentioned. Observations from older studies are considered in view of more recent information. Some of the older ob servations provided fundamental insights and paved the way for present day research; too often such data has been neglected or independently rediscovered. Today, poliovirus research has again attracted considerable interest. High points gained within the last few years were the elucidation of the complete nucleotide sequences of the RNAs of the three poliovinls serotypes and the corresponding vaccine strains, the demonstration of genome evolution during transmission of poliovirus in an epidemic, further characterization of the antigenic sites on the virus particle and of the antigenic drift, characterization of alternate conforma tional states of the virion capsid, the development of monoclonal antibodies against some of the virus proteins, observations on the role of the plasma membrane, cytoskeleton, and cytoplasmic membranes as mediators in the virus induced redirection of the synthetic machinery of the host cell, and characteriza"

In dies em Buch ist der Stand der Analytischen Chemie des Mangans fUr die Zeit- spanne von 1940 bis Anfang 1984 unter Beriicksichtigung von mehr a1s 2100 Litera- turstellen dargestellt. Vereinzelt sind, wo dies fUr den StoffUberb1ick niitz1ich er- schien, einige altere Literaturstellen einbezogen worden. Die Stoffbearbeitung ist praxisbezogen und setzt die Kenntnis der Grundlagen der behandelten Analysenmethoden voraus. Demnach wird auf eine eingehende Dar- stellung theoretischer und apparativer Grundlagen sowie auf die Beschreibung von Geraten der einzelnen Analysenmethoden verzichtet, urn den begrenzten Rahmen dieses Buches nicht zu sprengen. Allgemeine Hinweise werden nur soweit gegeben, als sie fUr die praktische Anwendung der einzelnen Analysenmethoden zweckmal3ig erscheinen. Abweichend davon wird lediglich bei der Plasmaspektrometrie auf allge- meine Grundlagen sowie wesentliche apparative und praktische Details der Me- thode in kurzgefal3ter Form naher eingegangen, da iiber diese noch relativ junge Analysenmethode zusammenfassende Darstellungen bis jetzt noch nicht in ausrei- chendem Mal3e zur VerfUgung stehen. Bei den Analysenvorschriften der Multiele- ment-Methoden sind neben den fUr Mangan spezifischen Angaben auch die notwen- digen Daten der mitbestimmten anderen Elemente mitangefUhrt, da dies fUr das Ver- standnis und die Anwendung der Analysenverfahren zweckmal3ig erscheint. Den Fachkollegen danke ich fUr die Unterstiitzung in Form von Sonderdrucken, Dokumentationen und Analysenvorschriften. Dem Herausgeber, Herrn Prof. Dr. W. Fresenius, und dem Verlag sei fUr die sehr verstandnisvolle, stets gute Zusam- menarbeit gedankt.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ De Articulo Homerico. (Progr., Thomassch. In Leipzig). Victor Hugo G. Koch