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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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The Molecular Biology of Poliovirus (Paperback, Softcover reprint of the original 1st ed. 1985)
Loot Price: R4,080
Discovery Miles 40 800
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The Molecular Biology of Poliovirus (Paperback, Softcover reprint of the original 1st ed. 1985)
Expected to ship within 10 - 15 working days
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Donate to Against Period Poverty
Total price: R4,100
Discovery Miles: 41 000
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Years ago when we were asked to write a book on the present-day
knowledge of the molecular biology of poliovirus, we did not expect
that such an apparently simple task could involve so much time and
effort. Our writing was hampered by the fact that both of us are
full time "workers," so that this monograph is mainly a spare time
expedience. The main attention of this book focuses on a detailed
review of the molecular biology of poliovirus and especially on the
advances of the last decade; medical and environmental aspects are
only briefly mentioned. Observations from older studies are
considered in view of more recent information. Some of the older ob
servations provided fundamental insights and paved the way for
present day research; too often such data has been neglected or
independently rediscovered. Today, poliovirus research has again
attracted considerable interest. High points gained within the last
few years were the elucidation of the complete nucleotide sequences
of the RNAs of the three poliovinls serotypes and the corresponding
vaccine strains, the demonstration of genome evolution during
transmission of poliovirus in an epidemic, further characterization
of the antigenic sites on the virus particle and of the antigenic
drift, characterization of alternate conforma tional states of the
virion capsid, the development of monoclonal antibodies against
some of the virus proteins, observations on the role of the plasma
membrane, cytoskeleton, and cytoplasmic membranes as mediators in
the virus induced redirection of the synthetic machinery of the
host cell, and characteriza"
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