This title was first published in 2003. In laboratories around the world the active principles in traditional herbal medicines are being isolated and characterized. A systematic effort at the Chinese Academy of Sciences is underway to identify the structure-activity relationships that result from the link between chemistry and medicine that is permitted by this data. This book, which provides the only systematic English-language description of the chemical structures and pharmacological effects of compounds active in traditional Chinese medicines (TCMs), is now in its second edition. The new edition provides English-language monographs on over 9000 chemicals isolated from nearly 4000 natural sources used in Chinese medicine and features the addition of in-depth bioactivity data for many of the compounds. Effects and indications of the medicines are included. Extensive indexing permits cross-referencing among English, Chinese and Latin names for natural medicinal sources, effects and indications, and the chemical components of the medicines. The second edition of Traditional Chinese Medicines includes 2300 new compounds, 2400 additional plant sources, more CAS Registry Numbers, and more pharmacological data. The structure of the book has been extensively reorganised to make cross referencing the data much simpler. This new edition is therefore a substantial improvement on the first edition of this important reference on the structural chemistry of traditional Chinese medicines.

This title was first published in 2003. In laboratories around the world the active principles in traditional herbal medicines are being isolated and characterized. A systematic effort at the Chinese Academy of Sciences is underway to identify the structure-activity relationships that result from the link between chemistry and medicine that is permitted by this data. This book, which provides the only systematic English-language description of the chemical structures and pharmacological effects of compounds active in traditional Chinese medicines (TCMs), is now in its second edition. The new edition provides English-language monographs on over 9000 chemicals isolated from nearly 4000 natural sources used in Chinese medicine and features the addition of in-depth bioactivity data for many of the compounds. Effects and indications of the medicines are included. Extensive indexing permits cross-referencing among English, Chinese and Latin names for natural medicinal sources, effects and indications, and the chemical components of the medicines. The second edition of Traditional Chinese Medicines includes 2300 new compounds, 2400 additional plant sources, more CAS Registry Numbers, and more pharmacological data. The structure of the book has been extensively reorganised to make cross referencing the data much simpler. This new edition is therefore a substantial improvement on the first edition of this important reference on the structural chemistry of traditional Chinese medicines.

This title was first published in 2000: The discovery, in the 1930s and 1940s, of antibiotics revolutionized the practice of medicine. Beginning with the streptomycins and the penicillins, hundreds of antibiotics have been developed and have come into routine use for the management of infectious diseases, opportunistic infections and infections resulting from trauma. This cornucopia of anti-infective agents has created a number of problems, not the least of which is the organization of information concerning them. This Handbook contains records for all the major drugs currently used in the treatment of infection. Monographs are provided for 1600 anti-infective agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number; and the Merck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

This title was first published in 2000: One of the most active areas in medicinal chemical research concerns the search for drugs used to treat different forms of cancer. This Handbook contains records for all the major drugs currently in use to treat cancer. Monographs are provided for 409 antineoplastic agents and, in addition, 23 cytoprotectant agents are described. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) Number, and the Merck Index (12th Edition) Number are given. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

This title was first published in 2000: Treatment of endocrine disorders is an important branch of medicine and many drugs have been developed for use in this area. Endocrine disorders and the drugs used to treat them are quite diverse, ranging from iodine-containing thyroxine analogs used to treat hypothyroidism, to steroid androgens, progestins and estrogens. This Handbook contains records for all the major drugs currently used in endocrinology. Monographs are provided for 818 endocrine agents and steroids. For each main entry, the following information is provided: the chemical name and a list of trade names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) Number, and the Merck Index (12th edition) Number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

This title was first published in 2002: Drugs: Synonyms and Properties provides comprehensive coverage of the 10,000 drugs currently in common use worldwide. Its overall organization and inclusion of detailed chemical information fills an important gap in drug information. This reference, edited by a worldaEURO"renowned authority in drug design and chemical information and now in its second edition, has become one of the bibles of pharmaceutical research and application. This book organizes the 10,000 drugs currently in use by therapeutic category. Therefore all tranquilizers, all antidepressants, or all anorexic agents, for example, are grouped together. In all, 204 categories are represented. This arrangement means that all drugs in a given category can be reviewed very easily and their relative properties compared quickly. A key component of this reference is the extensive coverage of synonyms. The book includes an index of over 30,000 drug synonyms and trade names with a crossaEURO"reference to their main entry. This extraordinarily comprehensive view of trade names and generic synonyms makes Drugs: Synonyms and Properties one of the worldaEURO(2)s most exhaustive references in its field. For each main entry, the following information is provided: chemical name and a list of trade names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) Number; the Merck Index (Twelfth Edition) Number; the physical properties of each compound; and the known biological activity and indicated applications. Indexes, including a master index of names and synonyms, and of manufacturers and suppliers, are appended. This reference will be invaluable to research chemists, biologists, and physicians and to anyone interested in drugs who, starting with a single synonym for a drug, will be able to quickly find a thumbnail sketch of the essential information concerning that agent.

* Provides all known names for each of the 386 chemicals listed, for a total of approximately 7340 separate names-an average of 19 names per chemical* Names are compiled from English and various foreign languages, especially the European languages* The chemical structure for each compound is given in standard form and, where known, the stereochemistry at chiral centers is indicated* The Handbook summarizes each pesticide's physical properties, specifically, its melting point, boiling point, density, solubility, and, when available, its octanol/water partition coefficient, whichis generally regarded as an indicator of its potential for absorption in the body]

This title was first published in 2000: Pesticides and other agricultural chemicals are in use in virtually every country in the world. It is therefore useful and important to those involved with these chemicals to have a collection of data concerning the substances most commonly used for agricultural purposes. This Handbook includes data on over 1,800 substances, including a number of mixtures, which are important in agriculture. Almost all records describing pure chemicals carry the appropriate CAS Registry Number and the associated EINECS Number. All chemicals in this edition which also appear in the twelfth edition of the Merck Index have the Merck Index Number provided. Wherever possible, the following information is also provided for each entry: definitions, classifications, chemical composition, functions, applications, suppliers, melting point, boiling point, density or specific gravity, refractive index, optical rotation, ultraviolet absorption, solubility, and acute toxicity.

This title was first published in 2000: One of the most active areas in medicinal chemical research concerns the search for drugs used to treat different forms of cancer. This Handbook contains records for all the major drugs currently in use to treat cancer. Monographs are provided for 409 antineoplastic agents and, in addition, 23 cytoprotectant agents are described. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) Number, and the Merck Index (12th Edition) Number are given. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

This title was first published in 2000: Treatment of endocrine disorders is an important branch of medicine and many drugs have been developed for use in this area. Endocrine disorders and the drugs used to treat them are quite diverse, ranging from iodine-containing thyroxine analogs used to treat hypothyroidism, to steroid androgens, progestins and estrogens. This Handbook contains records for all the major drugs currently used in endocrinology. Monographs are provided for 818 endocrine agents and steroids. For each main entry, the following information is provided: the chemical name and a list of trade names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) Number, and the Merck Index (12th edition) Number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

This title was first published in 2000: The discovery, in the 1930s and 1940s, of antibiotics revolutionized the practice of medicine. Beginning with the streptomycins and the penicillins, hundreds of antibiotics have been developed and have come into routine use for the management of infectious diseases, opportunistic infections and infections resulting from trauma. This cornucopia of anti-infective agents has created a number of problems, not the least of which is the organization of information concerning them. This Handbook contains records for all the major drugs currently used in the treatment of infection. Monographs are provided for 1600 anti-infective agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number; and the Merck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

This title was first published in 2000: Pesticides and other agricultural chemicals are in use in virtually every country in the world. It is therefore useful and important to those involved with these chemicals to have a collection of data concerning the substances most commonly used for agricultural purposes. This Handbook includes data on over 1,800 substances, including a number of mixtures, which are important in agriculture. Almost all records describing pure chemicals carry the appropriate CAS Registry Number and the associated EINECS Number. All chemicals in this edition which also appear in the twelfth edition of the Merck Index have the Merck Index Number provided. Wherever possible, the following information is also provided for each entry: definitions, classifications, chemical composition, functions, applications, suppliers, melting point, boiling point, density or specific gravity, refractive index, optical rotation, ultraviolet absorption, solubility, and acute toxicity.

The cardiovascular system serves to carry essential compounds to the tissues and to remove metabolic by-products. It also plays an important role in maintaining homeostasis, and functions directly or indirectly in the regulation of body temperature, oxygen supply, nutrient distribution, water and electrolyte balance, and endocrine activity. Consisting of a pump, connecting tubes, exchange membranes and blood, this system is governed by a diverse and complex array of regulatory mechanisms, encompassing central neural, autonomic, endocrine, paracrine, and autocrine control.

Drugs used in the treatment of cardiovascular disease are disseminated widely in western industrialized countries. In the US alone, nearly $18 billion was spent on drugs for the treatment of cardiovascular disease and stroke in 1999.

This "Handbook" contains records for all the major drugs that directly affect the cardiovascular system. Monographs are provided for over 1900 cardiovascular agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number; and the Merck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

The Autonomic Nervous System (ANS) supplies all innervated structures of the body other than skeletal muscle, and its effects are therefore pervasive. The range of available ANS-active compounds can effectively modulate any or all body systems. The ANS-active agents include drugs used to treat a wide spectrum of conditions including hypertension, myocardial insufficiency, migraine, nasal congestion, obesity, Parkinson's disease, and glaucoma. Drugs from an array of therapeutic categories, including vasodilators, muscle relaxants, gastroprokinetics, and bronchodilators, can be classified as ANS agents.

This "Handbook" contains records for all the major drugs that mimic or block the actions of ANS neurotransmitters or whose activities involve a direct effect on ANS neurotransmitter production, destruction or reuptake, or on junctional transmission. Monographs are provided for 1,996 ANS agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the "Merck Index" (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

Treatment of endocrine disorders is an important branch of medicine and many drugs have been developed for use in this area. Endocrine disorders and the drugs used to treat them are quite diverse, ranging from iodine-containing thyroxine analogs used to treat hypothyroidism, to steroid androgens, progestins and estrogens.

This "Handbook" contains records for all the major drugs currently used in endocrinology. Monographs are provided for 818 endocrine agents and steroids. For each main entry, the following information is provided: the chemical name and a list of trade names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) Number, and the Merck Index (12th edition) Number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.