The cardiovascular system serves to carry essential compounds to
the tissues and to remove metabolic by-products. It also plays an
important role in maintaining homeostasis, and functions directly
or indirectly in the regulation of body temperature, oxygen supply,
nutrient distribution, water and electrolyte balance, and endocrine
activity. Consisting of a pump, connecting tubes, exchange
membranes and blood, this system is governed by a diverse and
complex array of regulatory mechanisms, encompassing central
neural, autonomic, endocrine, paracrine, and autocrine control.
Drugs used in the treatment of cardiovascular disease are
disseminated widely in western industrialized countries. In the US
alone, nearly $18 billion was spent on drugs for the treatment of
cardiovascular disease and stroke in 1999.
This "Handbook" contains records for all the major drugs that
directly affect the cardiovascular system. Monographs are provided
for over 1900 cardiovascular agents. For each main entry, the
following information is provided: the chemical name and a list of
proprietary names and synonyms; the Chemical Abstracts Service
(CAS) Registry Number; the European Inventory of Existing
Commercial Chemical Substances (EINECS) number; and the Merck Index
(12th edition) number. The physical properties of each compound are
described and the known biological activity and indicated
applications are presented. The structure of each compound is
provided, together with a summary of the acute toxicity data
associated with it, and the manufacturers and suppliers of the drug
are also given. Indexes, including a master index of names and
synonyms, are appended.
General
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