The Autonomic Nervous System (ANS) supplies all innervated
structures of the body other than skeletal muscle, and its effects
are therefore pervasive. The range of available ANS-active
compounds can effectively modulate any or all body systems. The
ANS-active agents include drugs used to treat a wide spectrum of
conditions including hypertension, myocardial insufficiency,
migraine, nasal congestion, obesity, Parkinson's disease, and
glaucoma. Drugs from an array of therapeutic categories, including
vasodilators, muscle relaxants, gastroprokinetics, and
bronchodilators, can be classified as ANS agents.
This "Handbook" contains records for all the major drugs that
mimic or block the actions of ANS neurotransmitters or whose
activities involve a direct effect on ANS neurotransmitter
production, destruction or reuptake, or on junctional transmission.
Monographs are provided for 1,996 ANS agents. For each main entry,
the following information is provided: the chemical name and a list
of proprietary names and synonyms; the Chemical Abstracts Service
(CAS) Registry Number; the European Inventory of Existing
Commercial Chemical Substances (EINECS) number, and the "Merck
Index" (12th edition) number. The physical properties of each
compound are described and the known biological activity and
indicated applications are presented. The structure of each
compound is provided, together with a summary of the acute toxicity
data associated with it, and the manufacturers and suppliers of the
drug are also given. Indexes, including a master index of names and
synonyms, are appended.
General
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