|
Showing 1 - 5 of
5 matches in All Departments
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for
Experimental and Clinical Traumatology, Vienna, Austria The word
"sepsis" derives from the Greek meaning decay or rottenness.
Tradition ally this term has been used to describe the process of
infection accompanied by the host's systemic inflammatory response.
Based on that understanding, previous clin ical studies have been
designed to include only patients with positive blood cultures [1,
2]. However, the frequent occurrence of a septic response without
the demon stration of microorganisms in the circulation has led to
a new definition and under standing of sepsis, mainly as the
systemic response of the host to an often unde tectable
microbiological or non-microbiological process [3]. The general
consensus is that cytokines are central to the inflammatory
response, particularly in sepsis. It is now known that not only
Gram-negative but also Gram positive, viral, and fungal infections
initiate the complex cascades of cytokine release. Probably the
most important aspect of bacterial action is the release of toxic
bacterial products. In particular endotoxin from Gram-negative
bacteria (see chap ter by Schade) and super antigens (see chapter
by Neumann and Holzmann), as well as pore-forming toxins [4] from
Gram-positive bacteria, induce cytokine formation. The importance
of this cytokine release is evident from both diagnostic and thera
peutic (mostly experimental) studies, and the action of cytokines
may be the key to our understanding of the pathophysiology of the
sepsis syndrome.
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for
Experimental and Clinical Traumatology, Vienna, Austria The word
"sepsis" derives from the Greek meaning decay or rottenness.
Tradition ally this term has been used to describe the process of
infection accompanied by the host's systemic inflammatory response.
Based on that understanding, previous clin ical studies have been
designed to include only patients with positive blood cultures [1,
2]. However, the frequent occurrence of a septic response without
the demon stration of microorganisms in the circulation has led to
a new definition and under standing of sepsis, mainly as the
systemic response of the host to an often unde tectable
microbiological or non-microbiological process [3]. The general
consensus is that cytokines are central to the inflammatory
response, particularly in sepsis. It is now known that not only
Gram-negative but also Gram positive, viral, and fungal infections
initiate the complex cascades of cytokine release. Probably the
most important aspect of bacterial action is the release of toxic
bacterial products. In particular endotoxin from Gram-negative
bacteria (see chap ter by Schade) and super antigens (see chapter
by Neumann and Holzmann), as well as pore-forming toxins [4] from
Gram-positive bacteria, induce cytokine formation. The importance
of this cytokine release is evident from both diagnostic and thera
peutic (mostly experimental) studies, and the action of cytokines
may be the key to our understanding of the pathophysiology of the
sepsis syndrome.
Fibrin plays a prominent role in wound healing. It has a hemostatic
effect, induces cellular response to wound damage,' and, by forming
strands to build a matrix, assists in neovascularization and
fibroblast proliferation. The concept of using clotting substances
from human blood for wound manage- ment and to achieve hemostasis
in bleeding parenchymatous organs can be traced to 1909, when
Bergel [1] reported on the hemostatic effect of fibrin powder. In
1915, Grey [3] employed fibrin to control bleeding in neurosurgical
operations of the brain. A year later, Harvey [4] used fibrin
patches to stop bleeding from parenchy- matous organs in general
surgery. It took more than two decades for this ingenious idea to
be rediscovered. In 1940, Young and Medawar [8] reported on
experimental nerve anastomosis by sealing. Similarly, Tarlov and
Benjamin [7] reunited nerves with plasma clots in 1943. Tarlov
improved the results obtained with clot anastomosing of nerves by
avoiding tension at the nerve stumps. In 1944, Cronkite et al. [2]
reported on an initial series of eight cases in which fibrinogen
and thrombin had been used successfully for anchoring skin grafts.
The World Fantasy Award-winning third volume of the Lyonesse
trilogy brings attention to the faerie changeling Madouc. Where
princess Suldrun once meekly endured the proprieties of Castle
Haidion, Madouc defends herself with mischief. Vexed, King Casmir
and Queen Sollace arrange a contest to marry her off. However,
Madouc has other ideas, and leaves with the stableboy " Sir
Pom-pom" on a quest to learn the identity of her father,
encountering swindlers, faeries, trolls, ogres, a knight in search
of his youth, and a relatively pedestrian item known as the Holy
Grail. As the sorcerers Shimrod and Murgen investigate dire
portents in the world of magic, Casmir schemes to murder prince
Dhrun of Troicinet and bring all the lands under his iron rule;
however, his ambitions will be complicated by one small but
important oversight -- he's failed to allow for Madouc
Covering system architecture, implementation and testing, this work
is written by authors who are widely experienced with cellular
radio in general and with GSM in particular. It provides a
structured overview to help make sense of the GSM specifications
and surveys competing cellular systems such as NADC and CDMA.
Practical testing applications are explored in depth and compared
with similar techniques used with analogue cellular systems.
|
You may like...
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
Southpaw
Jake Gyllenhaal, Forest Whitaker, …
DVD
R99
R24
Discovery Miles 240
Sound Of Freedom
Jim Caviezel, Mira Sorvino, …
DVD
R325
R218
Discovery Miles 2 180
|