Hitching a ride on a rogue iceberg, a polar bear washes up on the north coast of Scotland and immediately causes havoc in a small fishing community. Intent on the media scoop of the decade, TV journalist Rebecca Riposte and her cameraman Ben are swiftly on its trail. But so, too, is Lord Tobias von Hindmarch - a man desperate to settle an old hunting score and bag the one trophy missing from his collection. Meanwhile, scientist Dan Travis flies in, his mission to play down the implications of the iceberg and bolster the government's melting green reputation. As the action converges and the body count rises, each must face challenges more deadly than their darkest fears.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

A groundbreaking work that identifies the real culprit behind one of the great economic crimes of our time-- the growing inequality of incomes between the vast majority of Americans and the richest of the rich.
We all know that the very rich have gotten a lot richer these past few decades while most Americans haven't. In fact, the exorbitantly paid have continued to thrive during the current economic crisis, even as the rest of Americans have continued to fall behind. Why do the "haveit- alls" have so much more? And how have they managed to restructure the economy to reap the lion's share of the gains and shift the costs of their new economic playground downward, tearing new holes in the safety net and saddling all of us with increased debt and risk? Lots of so-called experts claim to have solved this great mystery, but no one has really gotten to the bottom of it--until now.
In their lively and provocative "Winner-Take-All Politics, "renowned political scientists Jacob S. Hacker and Paul Pierson demonstrate convincingly that the usual suspects--foreign trade and financial globalization, technological changes in the workplace, increased education at the top--are largely innocent of the charges against them. Instead, they indict an unlikely suspect and take us on an entertaining tour of the mountain of evidence against the culprit. The guilty party is American politics. Runaway inequality and the present economic crisis reflect what government has done to aid the rich and what it has not done to safeguard the interests of the middle class. The winner-take-all economy is primarily a result of winner-take-all politics.
In an innovative historical departure, Hacker and Pierson trace the rise of the winner-take-all economy back to the late 1970s when, under a Democratic president and a Democratic Congress, a major transformation of American politics occurred. With big business and conservative ideologues organizing themselves to undo the regulations and progressive tax policies that had helped ensure a fair distribution of economic rewards, deregulation got under way, taxes were cut for the wealthiest, and business decisively defeated labor in Washington. And this transformation continued under Reagan and the Bushes as well as under Clinton, with both parties catering to the interests of those at the very top. Hacker and Pierson's gripping narration of the epic battles waged during President Obama's first two years in office reveals an unpleasant but catalyzing truth: winner-take-all politics, while under challenge, is still very much with us.
"Winner-Take-All Politics"--part revelatory history, part political analysis, part intellectual journey-- shows how a political system that traditionally has been responsive to the interests of the middle class has been hijacked by the superrich. In doing so, it not only changes how we think about American politics, but also points the way to rebuilding a democracy that serves the interests of the many rather than just those of the wealthy few.

In light of more recent conversations about religion and its import as a factor in the global geopolitical and cultural spheres, augmented by the "contracting" of relationship among people and nations, Communication and the Global Landscape of Faith highlights geographical, architectural, and a partial issues as significant and edifying dimensions of the study of communication and religion. Insights are gleaned through the prism of the philosophical, built, performative, political, and intercultural landscapes.

Communication theory provides a compelling way to understand how people of faith can and should work together in today's tumultuous world. In A Communication Perspective on Interfaith Dialogue, fifteen authors present their experiences and analyses of interfaith dialogue, and contextualize interfaith work within the frame of rhetorical and communication studies. While the focus is on the Abrahamic faiths, these essays also include discussion of Hinduism and interracial faith efforts. Each chapter incorporates communication theories that bring clarity to the practices and problems of interfaith communication. Where other interfaith books provide theological, political, or sociological insights, this volume is committed to the perspectives contained in communication scholarship. Interfaith dialogue is best imagined as an organic process, and it does not require theological heavyweights gathered for academic banter. As such, this volume focuses on the processes and means by which interfaith meaning is produced.

The secret motive for the assassination of John F. Kennedy lies deep within Renier University. The university president uses Renier as his playground and to advance his political career. He was designated to replace Lyndon Johnson on the 1964 Democratic Party ticket. Throuogh the experiences of faculty wife, Liz Hunter, we get a snapshot of life under his leadership.

Wittgenstein: Connections and Controversies consists of thirteen thematically linked essays on different aspects of the philosophy of Wittgenstein. After an introductory overview of Wittgenstein's philosophy the following essays fall into two classes. Some investigate connections between the philosophy of Wittgenstein and other philosophers or philosophical trends. Others enter into some of the controversies that, over the last two decades, have raged over the interpretation of one aspect or another of Wittgenstein's writings. These far-ranging essays, several of them previously unpublished or difficult to find, shed much light upon different aspects of Wittgenstein's thought, and upon the controversies which it has stimulated.

This volume focuses on controversial issues that stem from Philippa Foot's later writings on natural goodness which are at the center of contemporary discussions of virtue ethics. The chapters address questions about how Foot relates judgments of moral goodness to human nature, how Foot understands happiness, and addresses objections to her framework from the perspective of empirical biology. The volume will be of value to any student or scholar with an interest in virtue ethics and analytic moral philosophy.

The collapse of the financial markets in 2008 and the resulting 'Great Recession' merely accelerated an already worrisome trend: the shift away from an employer-based social welfare system in the United States. Since the end of World War II, a substantial percentage of the costs of social provision--most notably, unemployment insurance and health insurance--has been borne by employers rather than the state. The US has long been unique among advanced economies in this regard, but in recent years, its social contract has become so frayed that is fast becoming unrecognizable. Despite Obama's election, the burdens of social provision are falling increasingly upon individual families, and the situation is worsening because of the unemployment crisis. How can we repair the American social welfare system so that workers and families receive adequate protection and, if necessary, provision from the ravages of the market?
In Shared Responsibility, Shared Risk, Jacob Hacker and Ann O'Leary have gathered a distinguished group of scholars on American social policy to address this most fundamental of problems. Collectively, they analyze how the 'privatization of risk' has increased hardships for American families and increased inequality. They also propose a series of solutions that would distribute the burdens of risks more broadly and expand the social safety net. The range of issues covered is broad: health care, homeownership, social security and aging, unemployment, wealth (as opposed to income) creation, education, and family-friendly policies. The book is also comparative, measuring US social policy against the policies of other advanced nations. Given the current crisis in America social policy and the concomitant paralysis within government, the book has the potential to make an important intervention in the current debate.

This unique and much needed textbook will meet the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.
The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.
*Uses individual drugs to explain molecular actions
*Full color art program explains molecular and chemical concepts graphically
*Logical structure reflecting the current state of pharmacology and translational research, starting with receptors and finishing with target molecules
*Covers such intricacies as drug resistance and cell death
*Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

This comprehensive, interdisciplinary book covers different aspects of relevant human pathogens and commensals. The ongoing development of (meta-)genomic, transcriptomic, proteomic and bioinformatic analyses of pathogenic and commensal microorganisms and their host interaction provides a comprehensive introduction to the microbiological analysis of host-microbe interplay and its consequences for infection or commensalism.

Providing a picture of the processes of economic change in Europe, of which EU harmonization policies and transition policies form an integral part, the editors present a collection of articles on current issues in central and east European countries. Perhaps the most dramatic phenomenon to impact on Europe in the next two decades will be the economic integration of central and east European countries with the rest of Europe. Consequently, significant impacts should be seen in regional and international patterns of trade, demography, employment, and financial flows. The editors discuss the problems transitional economies will face and the strategies they may adopt in the context of the European economic integration process and these sectoral issues. Bringing together novel research by those within the emerging market economies, this book will be of great interest to researchers and policymakers and planners in organizations dealing with economic integration and transitional economy issues.

Strategies of Bacterial Interaction with Eukaryotic Cells *Tobias A. Oelschlaeger and Jorg Hacker 1. BENEFICIAL BACTERIAL-HOST INTERACTIONS Already during birth and soon thereafter mammals are colonized by bacte- ria belonging to the resident microbial flora. Cutaneous and mucosal sur- faces and the gastrointestinal tract are the areas which become colonized. These indigenous or autochthonous bacteria have a variety of beneficial effects on their hosts. They play a protective role by bacterial antagonism in fighting infections (Hoszowski and Truszczynski, 1997; Hentges, 1979). Pro- duction of vitamin K is another essential contribution of the resident microbial flora to the health of the host (Hill, 1997). Even more important, studies with germ-free animals demonstrated the involvement of the microbial flora on the development of the immune system. Such animals have underdeveloped and relatively undifferentiated lymphoid tissues and low concentrations of serum immune globulins ( Cebra et at., 1998). They TOBIAS A. OELSCHLAEGER and JORG HACKER Institut filr Molekulare lnfektionsbiologie, Universitiit Wiirzburg, 97070 Wiirzburg, Germany. *Corresponding author; Phone: (0)931-312150; FAX: (0)931-312578; E-mail: [email protected] xxix Tobias A. Oelschlaeger and Jorg Hacker also show defects in specific immune responsiveness and in nonspecific resistance induced by endotoxin, which may account for their lowered resis- tance. A more typical example of symbiotic interaction of bacteria with a host are bacteria like Ruminococcus in the gut of ruminants, essential for degradation of cellulose (Hobson, 1988). The closest benefical bacterial-host interactions are those of intracellular symbiotic bacteria and their host cells.

This detailed volume explores advances in vector design, DNA delivery, cell cultivation, host cell engineering, and bioprocess optimization within the study of recombinant protein expression in mammalian cells. The majority of the protocols employ either Chinese hamster ovary cells (CHO) or human embryonic kidney 293 cells (HEK293), the workhorses of the field, as the production host; however, the methods can be adapted to other mammalian hosts under the appropriate cell-specific conditions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and convenient, Recombinant Protein Expression in Mammalian Cells: Methods and Protocols aims to aid researchers in building on our knowledge of protein structure and function and to speed the discovery of new therapeutic proteins.

It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.