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Tending Adam's Garden describes and explains the way in which our
immune system works from a novel perspective. The book uses
metaphors and examples to bring the immune system to life and
explores the fundamental miracle of nature. Written in plain
language for a broad audience, this book encompasses much more than
just immunology, exploring more fundamental matters such as
causality, information, energy, evolution, cognition and
individuality, as well as the strategy of the immune system and its
role in health and disease.
* Provides a unique perspective on the immune system from one of
the keenest scientific and philosophical brains in the world
* Uses metaphors and case histories to explore themes in an
accessible manner
* Written in plain language requiring no specialized vocabulary or
specific scientific background in the subject
For a long time, immunology has been dominated by the idea of a
simple linear cause-effect relationship between the exposure to an
antigen and the production of specific antibodies against that
antigen. Clonal selection was the name of the theory based on this
idea and it has provided the main concepts to account for the known
features of the immune response. More recently, immunologists have
discovered a wealth of new facts, in the form of different
regulatory cells (helpers, suppressors, antigen presenting cells),
genetic determinations of immune responses such as those involved
in graft re jections, different molecular structures responsible
for intercellular interactions such as interleukins, cytokins,
idiotype-antiidiotype recognition and others. While furthering our
understanding of the local interactions (molecular and cellular) in
volved in the immune response, these discoveries have led to a
questioning of the simplicities of the classical clonal selection
theory. It is clear today that every single immune response is a
cooperative phenomenon involving several different molecular and
cellular interactions taking place in a coupled manner. In
addition, cross reactivity to different antigens has shown that
responses of the whole im mune system to different antigens are not
completely isolated from one another and that the history of
encounters with different antigens plays a crucial role in the
maturation of the whole system. Thus, problems of complexity,
generation of di versity and self-organization have entered the
field of immunology.
Based on a symposium covering latest research, this volume contains
contributions by international experts. They investigate the role
that viruses play in certain diseases, and include discussions of
animal models and human trials. Some of the chapters cover
specifically: streptococci and rheumatic heart disease,
Epstein-Barr infection and cancer, and molecular mimicry and
autoimmune disease.
This book provides a comprehensive review of T cell vaccination
which is a topic of significant interest in the field of
Immunology. However, its academic value is not limited to basic
research into the understanding of autoimmune T cell regulation in
vivo, for the research is supported by preliminary clinical
application. Indeed, T cell vaccinations have been tested in a
number of promising clinical trials as a potential treatment for
human auto-immune disease. T cell vaccination has thus evolved as
one of the most interesting topics of immunology and translational
medicine.
Because autoimmune disorders can wreak havoc in both humans and
animals, these disorders are now the objects of intense and focused
research. This book details specific animal models for a variety of
autoimmune disorders. The contributors are recognized authorities
who deal with the panoply of experimentally induced autoimmune
disorders, including encephalomyelitis, allergic neuritis,
uveoretinitis, myocarditis, and hepatitis. Also included are
discussions of spontaneously appearing diseases such as autoimmune
thyroiditis and systemic lupus erythematosus. Many other disorders
are also covered in this comprehensive guide. Certain to be an aid
in the planning of individual experiments and broader research
programs, this book will be a valuable addition to the library of
all practicing immunologists interested in immune system function
and dysfunction.
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