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The double-stranded (ds)RNA viruses represent a diverse group of
viruses that vary widely in host range (humans, animals, plants,
fungi, and bacteria), genome segment number (one to twelve), and
virion organization (T-number, capsid layers, or turrets). Members
of this fascinating group include the rotaviruses, renowned
globally as the commonest cause of gastroenteritis in young
children, and bluetongue virus, an economically important pathogen
of cattle and sheep. In recent years, remarkable progress has been
made in determining, at atomic and subnanometeric levels, the
structures of a number of key viral proteins and of the virion
capsids of several dsRNA viruses, highlighting the significant
parallels in the structure and replicative processes of many of
these viruses. By providing unique insights into fundamental
aspects of structure-function relationships in virus particles,
virus particle assembly, virus-cell interactions, and viral
pathogenesis, approaches for the development of
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