Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors. This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed. Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health.

The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments.

The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments.

Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors. This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed. Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health.

The life long close friendship of five very different, but strong women. Their families, and the men in their lives. Throw in secret sexual cravings, lies, unfulfilled desires and a suspicious death; and you ( the reader ) have to keep reminding yourself to breathe

Philosophy of Technology is a collection of short interviews based on 5 questions presented to some of the most influential and prominent scholars in this field. We hear their views on technology, its aim, scope, use, the future, and how their work fits in these respects.

This book offers an integrative examination of the role of motivation in shaping moral cognition, judgment, and behavior. How do we define good and bad? Where do our moral systems originate? These questions have long sparked inquiry across multiple disciplines, and scholars have debated the answer both within and across fields for centuries. Contributors examine the sociocultural context of morality including norms and norm compliance; psychological frameworks that underlie virtuous behavior and help navigate competing moral obligations; the neurobiology of moral reasoning, and more. In bringing together leading researchers across sociology, philosophy, psychology, and neuroscience, this book explains the complex motivational aspects of morality, which represents a crucial step toward understanding how and why our moral choices arise, and in turn can shape and guide how we engage in the daily practice of morality.

Was wurdest Du tun, lieber Leser, wenn Dir uber Nacht eine besondere Gabe verliehen wurde? Nimmst Du es ebenfalls alles andere als leicht? Helmut steht mit beiden Beinen im Leben. Liebt seine Arbeit und seine Freundin. Ein Geschenk zu seinem vierzigsten Geburtstag bringt ihn allerdings vollig aus dem Tritt. Plotzlich ist alles anders. Und die folgenden Tage lassen den Vierzigjahrigen im wahrsten Sinne des Wortes abheben. Willkommen in Helmuts Welt ...