Advances in pharmacogenomics and proteomics, along with the introduction of recombinant DNA technology, have expanded the applications of pharmacology to encompass a range of disciplines. Biomedical researchers, protein specialists, and molecular biologists are all involved in the development and delivery of novel drugs. Therefore, students in a variety of life sciences now require grounding in pharmacology.

Adding much new material, Introduction to Pharmacology, Third Edition familiarizes students with the curative action of specific drugs, along with current research and the multifaceted role of pharmacology in society.

New to the third edition-

- Chapters on smooth muscle pharmacology covering gastrointestinal and pulmonary pharmacology

- Pharmacology advances at the molecular level

- The historical background of the Watson Crick model of DNA

- Cutting edge topics such as RNA interference and dopamine signaling

The text begins with a discussion on the absorption, distribution, metabolism, and elimination of drugs. Much emphasis is placed on pharmacokinetic aspects: how drugs produce an effect and the quantification of these effects for comparative purposes. Also the text describes substance abuse pharmacology and the evolution of drug laws. Several chapters deal with the development of drugs and challenges faced in drug discovery.

Identifying both the therapeutic and toxicological aspects of drug use, Introduction to Pharmacology employs contemporary examples to help students become familiar with drug development and treatment, as well as possible adverse affects, and the impact of drug research and use on society today and into the future.

Advances in pharmacogenomics and proteomics, along with the introduction of recombinant DNA technology, have expanded the applications of pharmacology to encompass a range of disciplines. Biomedical researchers, protein specialists, and molecular biologists are all involved in the development and delivery of novel drugs. Therefore, students in a variety of life sciences now require grounding in pharmacology. Adding much new material, Introduction to Pharmacology, Third Edition familiarizes students with the curative action of specific drugs, along with current research and the multifaceted role of pharmacology in society. New to the third edition Chapters on smooth muscle pharmacology covering gastrointestinal and pulmonary pharmacology Pharmacology advances at the molecular level The historical background of the Watson Crick model of DNA Cutting edge topics such as RNA interference and dopamine signaling The text begins with a discussion on the absorption, distribution, metabolism, and elimination of drugs. Much emphasis is placed on pharmacokinetic aspects: how drugs produce an effect and the quantification of these effects for comparative purposes. Also the text describes substance abuse pharmacology and the evolution of drug laws. Several chapters deal with the development of drugs and challenges faced in drug discovery. Identifying both the therapeutic and toxicological aspects of drug use, Introduction to Pharmacology employs contemporary examples to help students become familiar with drug development and treatment, as well as possible adverse affects, and the impact of drug research and use on society today and into the future.

In the science fiction thriller The Blackbird Papers, plans for an anti-gravity propulsion system--developed by the Germans during World War II--mistakenly fall into the hands of Middle Eastern terrorists with one goal in mind: to develop the technology into the form of bioterrorism against Israel. In 1944, the Germans successfully launch a rocket to Mars in order to intimidate the Allies. After the vehicle crashes and the demonstration fails, an American Mars lander provides photographic evidence of the landing. Eventually, Hitler's director of armaments shares the plans with the prime minister of Japan. Dr. Anthony Church, an English physicist who is studying antigravity, ultimately discovers the plans, and his pro-Palestinian sentiments lead him to form an alliance with the terrorists. Ryan Carpenter, an American student, uncovers the plot and must find a way to foil the conspiracy against Israel without jeopardizing his relationship with his boss and mentor, Dr. Church. historical events that occurred during World War II, author Mannfred Hollinger, PhD, guides the reader into a gripping tale of bioterrorism that could cause widespread devastation in a world constantly threatened by the acts of terrorists.

Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans.
This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.