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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Endothelin Receptors - From the Gene to the Human (Hardcover)
Loot Price: R13,567
Discovery Miles 135 670
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Endothelin Receptors - From the Gene to the Human (Hardcover)
Series: Handbooks in Pharmacology and Toxicology
Expected to ship within 12 - 17 working days
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Since the discovery of endothelin, major advances have been made in
understanding the molecular structure and function of the
endothelin receptors. At least two subtypes of receptors,
designated ETA and ETB, have been identified through biochemical
and pharmacological techniques. These subtypes are cloned and
expressed and additional subtypes appear to exist. The biochemical
events involved in the signal transduction processes that
ultimately activate the cellular machinery involved in the
end-organ responses are presented, as are the mechanisms by which
the receptors recognize specific and different G-proteins.
Functions mediated by the receptors at the cellular, tissue and,
organ level are reviewed in detail, as well as the roles that they
may play a part in the physiologic and pathophysiologic processes
in animals and in humans.
This book is unique in its breadth of scope. The most recent and
important advances, from the intracellular level of the nucleus to
the functional effect that endothelin receptors mediate in intact
organs, are compiled and reviewed.
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