Endothelin Receptors - From the Gene to the Human (Hardcover)

Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans.
This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.

General

Imprint:	Crc Press
Country of origin:	United States
Series:	Handbooks in Pharmacology and Toxicology
Release date:	May 1995
First published:	1995
Series editors:	Mannfred A. Hollinger
Contributors:	Giora Z. Feuerstein • David P. Brooks • Derk J. Bergsma • Catherine E. Peishoff • Martin I. Freed • Diane K. Jorkasky • Eliot H. Ohlstein • Frank C. Barone • Robert N. Willette
Dimensions:	234 x 156 x 22mm (L x W x T)
Format:	Hardcover
Pages:	304
ISBN-13:	978-0-8493-5938-5
Categories:	Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Human biology & related topics > General Promotions
LSN:	0-8493-5938-4
Barcode:	9780849359385

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