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Physiological, pharmacological and molecular biological data
generated over the past three decades have demonstrated the
existence of two major families of extracellular receptors, the P1,
a family of four G-protein coupled receptors and the P2, a family
of at least 12 receptors responsive to purine (ATP, ADP) and
pyrimidine (UTP) nucleotides through which adenosine and ATP can
function as extracellular messengers. The present two-part volume
represents an integrated compendium of invited chapters by leading
researchers in the area focusing on advances in the understanding
of purinergic and pyrimidinergic signaling systems, their role(s)
in tissue function and pathophysiology and advances in developing
potential new medications based on the modulation of P1 and P2
receptor signaling processes. The volumes will thus provide the
reader with a topical, comprehensive and integrated overview of
this important area.
Physiological, pharmacological and molecular biological data
generated over the past three decades have demonstrated the
existence of two major families of extracellular receptors, the P1,
a family of four G-protein coupled receptors and the P2, a family
of at least 12 receptors responsive to purine (ATP, ADP) and
pyrimidine (UTP) nucleotides through which adenosine and ATP can
function as extracellular messengers. The present two-part volume
represents an integrated compendium of invited chapters by leading
researchers in the area focusing on advances in the understanding
of purinergic and pyrimidinergic signaling systems, their role(s)
in tissue function and pathophysiology and advances in developing
potential new medications based on the modulation of P1 and P2
receptor signaling processes. The volumes will thus provide the
reader with a topical, comprehensive and integrated overview of
this important area.
Physiological, pharmacological and molecular biological data
generated over the past three decades have demonstrated the
existence of two major families of extracellular receptors, the P1,
a family of four G-protein coupled receptors and the P2, a family
of at least 12 receptors responsive to purine (ATP, ADP) and
pyrimidine (UTP) nucleotides through which adenosine and ATP can
function as extracellular messengers. The present two-part volume
represents an integrated compendium of invited chapters by leading
researchers in the area focusing on advances in the understanding
of purinergic and pyrimidinergic signaling systems, their role(s)
in tissue function and pathophysiology and advances in developing
potential new medications based on the modulation of P1 and P2
receptor signaling processes. The volumes will thus provide the
reader with a topical, comprehensive and integrated overview of
this important area.
Physiological, pharmacological and molecular biological data
generated over the past three decades have demonstrated the
existence of two major families of extracellular receptors, the P1,
a family of four G-protein coupled receptors and the P2, a family
of at least 12 receptors responsive to purine (ATP, ADP) and
pyrimidine (UTP) nucleotides through which adenosine and ATP can
function as extracellular messengers. The present two-part volume
represents an integrated compendium of invited chapters by leading
researchers in the area focusing on advances in the understanding
of purinergic and pyrimidinergic signaling systems, their role(s)
in tissue function and pathophysiology and advances in developing
potential new medications based on the modulation of P1 and P2
receptor signaling processes. The volumes will thus provide the
reader with a topical, comprehensive and integrated overview of
this important area.
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