Offering the most current and complete coverage of nucleoside analog activity in oncology and hematology, this single-source volume includes topics from pharmacology to previously unpublished clinical findings on the pivotal role of fludarabine, cladribine, and pentostatin in the management of diseases, such as chronic lymphocytic and hairy cell leukemia, non-Hodgkin's lymphoma, membranous nephropathy, and rheumatoid and psoriatic arthritis.

150 years after the first description of the clinical picture of "white blood" and the introduction of the term "leukemia" by R. Virchow it appears, that the leukemias, and the acute leukemias in particular, serve as an impressive example for the major improvements that have been achieved in the treatment but also in the understand ing of the biology of malignant dis orders. The international symposia "Acute Leukemia" which are held at Munster since 1986 have developed into an interna tional forum to review the current progress and the future perspectives of leukemia research and therapy at a high scientific and clinicallevel. Since the possibility for active participation in these symposia is somewhat restricted we are glad to have the opportunity to extend the information that was presented at the symposium "Acute Leukemias V - Experimental Approaches and Management of Refractory Disease" which was held from February 27 to March 2, 1994 to a broader audience of basic scientists and clinicians. This meeting was especiaIly designed to discuss experimen tal approaches and the management of refractory disease which allows to evaluate new experimental therapies on the basis of preclinical studies."

Christopher Dawson wrote The Judgment of the Nations in 1943, in the midst of the horrors of World War II. He took four years in the writing of it, years, he claimed, "more disastrous than any that Europe had known since the fourteenth century." By his own admission it had cost him greater labour and thought than any other book he had written. It is, perhaps, his most characteristic work. Dawson argues in compressed form for what he laid out more systematically in other books: his view that the West was at an hour of crisis and was fighting for its life as a civilisation. He did not view the disasters of the two World Wars as the cause of that disintegration; they were rather symptoms of a much deeper malaise, that of the loss of the spiritual vision that had created and sustained Western culture through the centuries. He lays out his understanding of what might be necessary for the West to reengage its spiritual and cultural roots and find a new way forward. For Dawson, such a restoration could not be coercive, but needed rather to be based upon a new perception of the inherent cultural creativity of Christianity. The Judgment of the Nations was widely praised upon publication. The Guardian called it "an appraisement of the contemporary situation by an historical thinker of the first importance," and the Irish Independent "a monument, alike of historical and of philosophical erudition." It was Dawson's hope in this work to describe the nature of the spiritual struggle Europe was facing, to map out its true lines, and to point the way through an impending and perhaps probable disaster to a renewal of European life, a renewal whose success or failure would have a decisive impact on the entire world.