This contributed volume presents state-of-the-art advances in logistics theory in various fields as well as case studies. The book reports on a number of recently conducted studies in the Dinalog and the EffizienzCluster LogistikRuhr, thus bridging the gap between different perspectives of theoretical and applied research. A selection of theoretical topics, practical examples, case studies and project reports is presented in this volume. The editors carefully selected contributions from a wide variety of projects, which were carried out in both the Dinalog cluster and the Effizienzcluster LogistikRuhr. The contributions are grouped in five main sections, each representing key domains in the evolution of logistics and supply chain management: sustainability, urban logistics, value chain management, IT-based innovation, knowledge management. This book is intended for both researchers and practitioners in the field of logistics and supply chain management, to serve as an important source of information for further research as well as to stimulate further innovation.

This edited monograph brings together research papers covering the state of the art in cloud computing for logistics. The book includes general business object models for intralogistics as well as user-friendly methods for logistics business process design. It also presents a general template for logistics applications from the cloud. The target audience primarily comprises researchers and experts in the field, but the book will also be beneficial for graduate students.

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity, as well as the different physiological roles they play, techniques used for studying TRP channels range from single molecular analysis to behavioral animal studies. Methods in multiple areas, such as molecular biology, fluorescence imaging, electrophysiology, cell biology, genetics, proteomics, pharmacology, system physiology, and behavioral assessment, are employed to investigate various aspects of these channels. Choosing among many possible topics in these broad areas was a daunting task. A comprehensive review of the field, TRP Channels spans the information gap by providing broad coverage of current methods and techniques commonly used in TRP channel research, and detailed protocols with thorough discussions of the advantages and disadvantages across methods. Some topics covered include Mammalian, Drosophila and C. elegans TRP channels Practical protocols for functional studies of TRP channels, including TRPC, TRPV, TRPA, TRPM and the intracellularly localized TRPML channels ThermoTRPs, including the new fast temperature jump apparatus and the high throughput random mutagenesis method for screening critical motifs involved in TRP channel regulation Cell-based high-throughput screening assays for TRP channels and their applications in drug discoveries TRP channel functions in native cells, including smooth muscles, neurons, and cancers Showcasing the current status of the field, TRP Channels covers the major techniques used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Because of the breadth of the TRP field, the applications of some methods are described in multiple chapters by experts working on a variety of channel types that serve different physiological functions, highlighting distinctive views on how the methodology can be utilized. Some chapters include discussion on the usefulness and pitfalls associated with the use of certain techniques. Together with chapters that offer comprehensive reviews on the functional regulation and other roles of TRP channels, students and investigators new to the field should find this book particularly informative.

This edited monograph brings together research papers covering the state of the art in cloud computing for logistics. The book includes general business object models for intralogistics as well as user-friendly methods for logistics business process design. It also presents a general template for logistics applications from the cloud. The target audience primarily comprises researchers and experts in the field, but the book will also be beneficial for graduate students.

This contributed volume presents state-of-the-art advances in logistics theory in various fields as well as case studies. The book reports on a number of recently conducted studies in the Dinalog and the EffizienzCluster LogistikRuhr, thus bridging the gap between different perspectives of theoretical and applied research. A selection of theoretical topics, practical examples, case studies and project reports is presented in this volume. The editors carefully selected contributions from a wide variety of projects, which were carried out in both the Dinalog cluster and the Effizienzcluster LogistikRuhr. The contributions are grouped in five main sections, each representing key domains in the evolution of logistics and supply chain management: sustainability, urban logistics, value chain management, IT-based innovation, knowledge management. This book is intended for both researchers and practitioners in the field of logistics and supply chain management, to serve as an important source of information for further research as well as to stimulate further innovation.

Informationstechnologien vom Scannen eines Barcodes bis zur Anwendung Künstlicher Intelligenz sind aus der modernen Logistik nicht mehr wegzudenken. Dieses Buch beschreibt in sechs Kapiteln die chronologische Entwicklung von den Anfängen der Logistik-IT auf dem Feld der Identifikation logistischer Objekte über den industriellen Status Quo der Lagerverwaltung und -steuerung hin zu zukunftsweisenden Konzepten der Industrie 4.0 und der Vision einer logistischen Plattformökonomie. Im Mittelpunkt der Betrachtung stehen intralogistische Anwendungen und das Zusammenspiel von Menschen und Technik in der Logistikwelt von morgen.

Experten aus Wissenschaft und Technik fordern ein Umdenken in der Intralogistik: weg von durchgeplanten, vorherbestimmten Systemen, hin zu einem Netzwerk gleichberechtigter Einheiten, die keiner ubergeordneten Koordination bedurfen. In dem Band werden die notwendigen Komponenten, die Softwarearchitektur und die Potenziale dieser neuen Technologie beschrieben. Anwendungsbeispiele liefern Entwicklern und Planern eine Grundlage fur die Gestaltung moderner Materialflusssysteme in der Industrie."

The new media environment has challenged the role of professional journalists as the primary source of politically relevant information. After Broadcast News puts this challenge into historical context, arguing that it is the latest of several critical moments, driven by economic, political, cultural, and technological changes, in which the relationship among citizens, political elites, and the media has been contested. Out of these past moments, distinct media regimes eventually emerged, each with its own seemingly natural rules and norms, and each the result of political struggle with clear winners and losers. The media regime in place for the latter half of the twentieth century has been dismantled, but a new regime has yet to emerge. Assuring this regime is a democratic one requires serious consideration of what was most beneficial and most problematic about past regimes and what is potentially most beneficial and most problematic about today's new information environment.

How do I get an agent?" "How do I get in the room where it happens?" "How do I hang on to my happiness, confidence, and self-esteem?" The answers to these questions, and other ideas and suggestions, are all waiting inside Climbing Rejection Mountain by Broadway veteran and former Equity President Nick Wyman. This is a book for everyone who loves theater and wonders how actors make a living, but it is most especially a book for those who are trying to make (or hoping to make) a life in theater. Students in high school and college who are contemplating life as an actor and actors just starting out in their careers will find in these pages an amusing gold mine of useful knowledge-and actors further on in their careers will also find this book instructive, beneficial, and entertaining. Climbing Rejection Mountain is highlighted by anecdotes from Mr. Wyman's long, illustrious career (sixteen Broadway shows) as well as dozens of clever, amusing cartoons by the noted Broadway actor (seventeen Broadway shows) Michael X. Martin. Making a life as an actor is difficult, but this book-full of practical advice and guidelines for approaching not only acting but life-will make it easier and more fun.

From a rising literary star, an epic historical novel, set against the tense backdrop of the Long March and Mao's rise to power, that tells a powerful and moving story of two ordinary peopleChina, 1934: A naive orphan and shy gunsmith, Ping, has fallen in love with Yong, who is a sophisticated veteran, a skilled marksman, and a true believer in Marxist ideology. Winning her affections will take an ideological battle-something he does not understand. To make matters worse, Yong has shown interest in Ping's best friend, Luo. On the eve of a great Communist defeat, Ping sabotages Luo's rifle, causing the bullet to backfire into his friend's head. The army begins its year-long retreat, known as The Long March, and Yong turns to Ping for comfort and companionship. Ping deeply regrets killing his friend, and as his relationship with Yong blossoms, he is saddened that it will always be colored by guilt. Yong soon becomes pregnant. She hates the way the baby inside is changing her, both physically and emotionally. The Red Army can't retreat with a crying infant, so they need to find someone close to take the baby in. Ping and Yong leave their son with a woman, promising to return once the war is won. When World War II breaks out and Japanese soldiers arrive, their 12-year-old son decides to enlist in the Japanese army to find his parents, though he quickly begins to fear for his life . . . Deeply moving and brilliantly written, Michael X. Wang's Lost in the Long March is an exploration of how the history of a country is always its people, though their stories are often the first to be lost.

Grundlagenwerk zur Intralogistik: Materialflusssysteme als Symbiose betrieblicher Organisation und physischer, foerdertechnischer Umsetzung stehen hier im Mittelpunkt. Zahlreiche Tabellen, Grafiken und technische Daten sowie eine Fulle von Systembeispielen und Auswahlmoeglichkeiten liefern den vollstandigen UEberblick uber alle Komponenten. Beim Abwagen der grossen Auswahl an Gestaltungsmoeglichkeiten, die aus den zahlreich vorhandenen Technologien hervorgeht, steht diese 3., voellig neu bearbeitete Auflage Studierenden, Praktikern, Planern und Entscheidern zur Seite. Eine Einfuhrung in die Planung und analytische Berechnung von Materialflusssystemen vervollstandigt dieses Buch und unterstutzt bei der Erfullung zentraler logistischer Funktionen.

This open access book provides a comprehensive view on data ecosystems and platform economics from methodical and technological foundations up to reports from practical implementations and applications in various industries. To this end, the book is structured in four parts: Part I "Foundations and Contexts" provides a general overview about building, running, and governing data spaces and an introduction to the IDS and GAIA-X projects. Part II "Data Space Technologies" subsequently details various implementation aspects of IDS and GAIA-X, including eg data usage control, the usage of blockchain technologies, or semantic data integration and interoperability. Next, Part III describes various "Use Cases and Data Ecosystems" from various application areas such as agriculture, healthcare, industry, energy, and mobility. Part IV eventually offers an overview of several "Solutions and Applications", eg including products and experiences from companies like Google, SAP, Huawei, T-Systems, Innopay and many more. Overall, the book provides professionals in industry with an encompassing overview of the technological and economic aspects of data spaces, based on the International Data Spaces and Gaia-X initiatives. It presents implementations and business cases and gives an outlook to future developments. In doing so, it aims at proliferating the vision of a social data market economy based on data spaces which embrace trust and data sovereignty.

This open access book provides a comprehensive view on data ecosystems and platform economics from methodical and technological foundations up to reports from practical implementations and applications in various industries. To this end, the book is structured in four parts: Part I "Foundations and Contexts" provides a general overview about building, running, and governing data spaces and an introduction to the IDS and GAIA-X projects. Part II "Data Space Technologies" subsequently details various implementation aspects of IDS and GAIA-X, including eg data usage control, the usage of blockchain technologies, or semantic data integration and interoperability. Next, Part III describes various "Use Cases and Data Ecosystems" from various application areas such as agriculture, healthcare, industry, energy, and mobility. Part IV eventually offers an overview of several "Solutions and Applications", eg including products and experiences from companies like Google, SAP, Huawei, T-Systems, Innopay and many more. Overall, the book provides professionals in industry with an encompassing overview of the technological and economic aspects of data spaces, based on the International Data Spaces and Gaia-X initiatives. It presents implementations and business cases and gives an outlook to future developments. In doing so, it aims at proliferating the vision of a social data market economy based on data spaces which embrace trust and data sovereignty.

The revolution in digital communications has altered the relationship between citizens and political elites, with important implications for democracy. As new information ecosystems have evolved, as unforeseen examples of their positive and negative consequences have emerged, and as theorizing, data, and research methods have expanded and improved, the central question has shifted from if the digital information environment is good or bad for democratic politics to how and in what contexts particular attributes of this environment are having an influence. It is only through the careful analysis of specific cases that we can begin to build a more comprehensive and nuanced understanding of the role of digital media in democratic theory and practice. The essays in Digital Media and Democratic Futures focus on a variety of information and communication technologies, politically relevant actors, substantive issues, and digital political practices, doing so from distinct theoretical perspectives and methodological approaches. Individually, each of these case studies provides deep insights into the complex and context-dependent relationship between media and democracy. Collectively, they show that there is no single outcome for democracy in the digital age, only a range of possible futures. Contributors: Rena Bivens, Michael X. Delli Carpini, Jennifer Earl, Thomas Elliott, Deen Freelon, Kelly Gates, Philip N. Howard, Daniel Kreiss, Ting Luo, Helen Nissenbaum, Beth Simone Noveck, Jennifer Pan, Lisa Poggiali, Daniela Stockmann.

Strabismus is a disorder in which the eyes are misaligned. This volume is the most advanced reference for techniques in diagnosis and treatment of strabismus. Chapters cover diagnosis of, surgical and nonsurgical treatments for, and management of esotropia (eyes aligned inward) exotropia (eyes aligned outward), dissociated strabismus complex, paralytic strabismus, restrictive strabismus, and nystagmus. It also contains a chapter on reoperation strategies.

The new media environment has challenged the role of professional journalists as the primary source of politically relevant information. After Broadcast News puts this challenge into historical context, arguing that it is the latest of several critical moments, driven by economic, political, cultural, and technological changes, in which the relationship among citizens, political elites, and the media has been contested. Out of these past moments, distinct media regimes eventually emerged, each with its own seemingly natural rules and norms, and each the result of political struggle with clear winners and losers. The media regime in place for the latter half of the twentieth century has been dismantled, but a new regime has yet to emerge. Assuring this regime is a democratic one requires serious consideration of what was most beneficial and most problematic about past regimes and what is potentially most beneficial and most problematic about today's new information environment.

Challenging the conventional wisdom that Americans are less engaged than ever in national life and the democratic process, "Talking Together "paints the most comprehensive portrait available of public deliberation in the United States and explains why it is important to America's future.

The authors' original and extensive research reveals how, when, and why citizens talk to each other about the issues of the day. They find that--in settings ranging from one-on-one conversations to e-mail exchanges to larger and more formal gatherings--a surprising two-thirds of Americans regularly participate in public discussions about such pressing issues as the Iraq War, economic development, and race relations. Pinpointing the real benefits of public discourse while considering arguments that question its importance, "Talking Together" presents an authoritative and clear-eyed assessment of deliberation's function in American governance. In the process, it offers concrete recommendations for increasing the power of talk to foster political action.

In searching for answers as to why young people differ vastly from their parents and grandparents when it comes to turning out the vote, A New Engagement challenges the conventional wisdom that today's youth is plagued by a severe case of political apathy. In order to understand the current
nature of citizen engagement, it is critical to separate political from civic engagement. Using the results from an original set of surveys and the authors' own primary research, they conclude that while older citizens participate by voting, young people engage by volunteering and being active in
their communities.

Steeped in a long history of violence and suffering, Michael X. Wang's debut collection of short stories interrogates personal and political events set against the backdrop of China that are both real and perceived, imagined and speculative. Wang plunges us into the fictional Chinese village of Xinchun and beyond to explore themes of tradition, family, modernity, and immigration in a country grappling with its modern identity. Violence enters the pastoral when Chinese villagers are flung down a well by Japanese soldiers and forced to abandon their crops and families to work in the coal mines, a tugboat driver dredges up something more than garbage polluting the Suzhou River, and rural and urban landscapes are pitted against each other when young villagers are promised high-paying work in the city but face violent persecution instead. In this world where China has regressed back to its imperial days, we meet an emperor who demands total servitude and swift punishment for attempts at revolution, and we follow a father who immigrates to the United States for a better life and loses everything in a tragic accident-aside from his estranged son-with whom he stubbornly refuses to make amends. Further News of Defeat is rich with characters who have known struggle and defeat and who find themselves locked in pivotal moments of Chinese history-such as World War II and the Tiananmen Square massacre-as they face losses of the highest order and still find cause for revival. Further News of Defeat is the winner of the 2019 Autumn House Press Fiction Prize.