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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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TRP Channels (Paperback)
Loot Price: R2,404
Discovery Miles 24 040
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TRP Channels (Paperback)
Series: Methods in Signal Transduction Series
Expected to ship within 12 - 19 working days
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The rapid expansion of the TRP field has generated a large amount
of excellent original work across many different research fields.
However, investigators are not necessarily familiar with the pros
and cons of the variety of methods used to study TRP channels.
Because of functional and genetic diversity, as well as the
different physiological roles they play, techniques used for
studying TRP channels range from single molecular analysis to
behavioral animal studies. Methods in multiple areas, such as
molecular biology, fluorescence imaging, electrophysiology, cell
biology, genetics, proteomics, pharmacology, system physiology, and
behavioral assessment, are employed to investigate various aspects
of these channels. Choosing among many possible topics in these
broad areas was a daunting task. A comprehensive review of the
field, TRP Channels spans the information gap by providing broad
coverage of current methods and techniques commonly used in TRP
channel research, and detailed protocols with thorough discussions
of the advantages and disadvantages across methods. Some topics
covered include Mammalian, Drosophila and C. elegans TRP channels
Practical protocols for functional studies of TRP channels,
including TRPC, TRPV, TRPA, TRPM and the intracellularly localized
TRPML channels ThermoTRPs, including the new fast temperature jump
apparatus and the high throughput random mutagenesis method for
screening critical motifs involved in TRP channel regulation
Cell-based high-throughput screening assays for TRP channels and
their applications in drug discoveries TRP channel functions in
native cells, including smooth muscles, neurons, and cancers
Showcasing the current status of the field, TRP Channels covers the
major techniques used in various areas of research. The majority of
the chapters are protocol oriented, with the goal of providing
clear directions for laboratory use. Because of the breadth of the
TRP field, the applications of some methods are described in
multiple chapters by experts working on a variety of channel types
that serve different physiological functions, highlighting
distinctive views on how the methodology can be utilized. Some
chapters include discussion on the usefulness and pitfalls
associated with the use of certain techniques. Together with
chapters that offer comprehensive reviews on the functional
regulation and other roles of TRP channels, students and
investigators new to the field should find this book particularly
informative.
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