This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

A proof is a successful demonstration that a conclusion necessarily follows by logical reasoning from axioms which are considered evident for the given context and agreed upon by the community. It is this concept that sets mathematics apart from other disciplines and distinguishes it as the prototype of a deductive science. Proofs thus are utterly relevant for research, teaching and communication in mathematics and of particular interest for the philosophy of mathematics. In computer science, moreover, proofs have proved to be a rich source for already certified algorithms. This book provides the reader with a collection of articles covering relevant current research topics circled around the concept 'proof'. It tries to give due consideration to the depth and breadth of the subject by discussing its philosophical and methodological aspects, addressing foundational issues induced by Hilbert's Programme and the benefits of the arising formal notions of proof, without neglecting reasoning in natural language proofs and applications in computer science such as program extraction.

This textbook presents concepts and applications of Management Accounting, one of the main approaches used by management to support future organisational performance. It covers methods and instruments of management and cost accounting, cost management, and management control and is based on the German textbook "Interne Unternehmensrechnung" by Ralf Ewert and Alfred Wagenhofer (Springer). The authors describe the managerial uses of accounting information, both for decision-making and decision-influencing, and provide a broad perspective on the subject combining the academic foundations of the field with recent cutting-edge research results. Moreover, traditions of German accounting theory and practice that are little known outside of the German-speaking countries are reflected in the book. With its unique approach based on information economics, the textbook offers a comprehensive and innovative presentation to a global audience.

This book provides an introduction to investment appraisal and presents a range of methods and models, some of which are not widely known, or at least not well covered by other textbooks. Each approach is thoroughly described, evaluated and illustrated using examples, with its assumptions and limitations analyzed in terms of their implications for investment decision-making practice. Investment decisions are of vital importance to all companies. Getting these decisions right is crucial but, due to a complex and dynamic business environment, this remains a challenging management task. Effective appraisal methods are valuable tools in supporting investment decision-making. As organisations continue to seek a competitive edge, it is increasingly important that management accountants and strategic decision-makers have a sound knowledge of these tools.

Seven review articles and original papers provide a representative overview of the research work done in hydrogen bond research at Austrian universities. The topics covered by the contributions are: state-of-the-art of understanding hydrogen bonding in biopolymers; recent NMR techniques for studying hydrogen bonding in aqueous solutions; intramolecular hydrogen bonding and proton transfer in a class of Mannich bases derived from substituted phenols and naphthols; competition between intramolecular hydrogen bonds in ortho-disubstituted phenols; molecular dynamic simulations on proton transfer in 5,8-dihydroxynaphthoquinone and in the formic acid dimer; accurate calculations of the intermolecular interactions in cyanoacetylen dimers; correlation between OH...O bond distances and OH stretching frequencies as derived from structural and spectroscopic data of minerals.

Over the last few decades the interest of logicians and mathematicians in constructive and computational aspects of their subjects has been steadily growing, and researchers from disparate areas realized that they can benefit enormously from the mutual exchange of techniques concerned with those aspects. A key figure in this exciting development is the logician and mathematician Helmut Schwichtenberg to whom this volume is dedicated on the occasion of his 70th birthday and his turning emeritus. The volume contains 20 articles from leading experts about recent developments in Constructive set theory, Provably recursive functions, Program extraction, Theories of truth, Constructive mathematics, Classical vs. intuitionistic logic, Inductive definitions, and Continuous functionals and domains.

At first glance, Robinson's original form of nonstandard analysis appears nonconstructive in essence, because it makes a rather unrestricted use of classical logic and set theory and, in particular, of the axiom of choice. Recent developments, however, have given rise to the hope that the distance between constructive and nonstandard mathematics is actually much smaller than it appears. So the time was ripe for the first meeting dedicated simultaneously to both ways of doing mathematics and to the current and future reunion of these seeming opposites.

Consisting of peer-reviewed research and survey articles written on the occasion of such an event, this volume offers views of the continuum from various standpoints. Including historical and philosophical issues, the topics of the contributions range from the foundations, the practice, and the applications of constructive and nonstandard mathematics, to the interplay of these areas and the development of a unified theory.

This book has developed over the past fifteen years from a modern course on stochastic chemical kinetics for graduate students in physics, chemistry and biology. The first part presents a systematic collection of the mathematical background material needed to understand probability, statistics, and stochastic processes as a prerequisite for the increasingly challenging practical applications in chemistry and the life sciences examined in the second part. Recent advances in the development of new techniques and in the resolution of conventional experiments at nano-scales have been tremendous: today molecular spectroscopy can provide insights into processes down to scales at which current theories at the interface of physics, chemistry and the life sciences cannot be successful without a firm grasp of randomness and its sources. Routinely measured data is now sufficiently accurate to allow the direct recording of fluctuations. As a result, the sampling of data and the modeling of relevant processes are doomed to produce artifacts in interpretation unless the observer has a solid background in the mathematics of limited reproducibility. The material covered is presented in a modular approach, allowing more advanced sections to be skipped if the reader is primarily interested in applications. At the same time, most derivations of analytical solutions for the selected examples are provided in full length to guide more advanced readers in their attempts to derive solutions on their own. The book employs uniform notation throughout, and a glossary has been added to define the most important notions discussed.

This book examines the uniforms and badges of an almost forgotten group of soldiers - Don, Kuban, Terek and Siberian Cossack units that fought with the German Wehrmacht during World War II. With the cooperation of former members of many Cossack units the authors have collected a great deal of material - much of the information I this book appears in print here for the first time. Among the subjects covered are: Cossacks in the Imperial Russian Army; the uniforms and badges of the Cossacks in the Wehrmacht in World War II, including collar insignia, Cossack headgear, sleeve badges (arm shields), Cossack qualification badges, decorations awarded to Cossacks; flags and command symbols of the Cossack units.

This book has developed over the past fifteen years from a modern course on stochastic chemical kinetics for graduate students in physics, chemistry and biology. The first part presents a systematic collection of the mathematical background material needed to understand probability, statistics, and stochastic processes as a prerequisite for the increasingly challenging practical applications in chemistry and the life sciences examined in the second part. Recent advances in the development of new techniques and in the resolution of conventional experiments at nano-scales have been tremendous: today molecular spectroscopy can provide insights into processes down to scales at which current theories at the interface of physics, chemistry and the life sciences cannot be successful without a firm grasp of randomness and its sources. Routinely measured data is now sufficiently accurate to allow the direct recording of fluctuations. As a result, the sampling of data and the modeling of relevant processes are doomed to produce artifacts in interpretation unless the observer has a solid background in the mathematics of limited reproducibility. The material covered is presented in a modular approach, allowing more advanced sections to be skipped if the reader is primarily interested in applications. At the same time, most derivations of analytical solutions for the selected examples are provided in full length to guide more advanced readers in their attempts to derive solutions on their own. The book employs uniform notation throughout, and a glossary has been added to define the most important notions discussed.

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

This book provides an introduction to investment appraisal and presents a range of methods and models, some of which are not widely known, or at least not well covered by other textbooks. Each approach is thoroughly described, evaluated and illustrated using examples, with its assumptions and limitations analyzed in terms of their implications for investment decision-making practice. Investment decisions are of vital importance to all companies. Getting these decisions right is crucial but, due to a complex and dynamic business environment, this remains a challenging management task. Effective appraisal methods are valuable tools in supporting investment decision-making. As organisations continue to seek a competitive edge, it is increasingly important that management accountants and strategic decision-makers have a sound knowledge of these tools.

This book contains all invited contributions of an interdisciplinary workshop of the UNESCO working group on systems analysis of the European and North American region entitled "Stochastic Phenomena and Chaotic Behaviour in Complex Systems." The meeting was held at Hotel Winterthalerhof in Flattnitz, Karnten, Austria from June 6-10, 1983. This workshop brought together some 20 mathematicians, physicists, chemists, biologists, psychologists and economists from different European and American coun tries who share a common interest in the dynamics of complex systems and their ana lysis by mathematical techniques. The workshop in Flattnitz continued a series of meetings of the UNESCO working group on systems analysis which started in 1977 in Bucharest and was continued in Cambridge, U.K., 1981 and in Lyon, 1982. The title of the meeting was chosen in order to focus on one of the current problems of the analysis of dynamical systems. A deeper understanding of the vari ous sources of stochasticity is of primary importance for the interpretation of experimental observations. Chaotic dynamics plays a central role since it intro duces a stochastic element into deterministic systems."

At first glance, Robinson's original form of nonstandard analysis appears nonconstructive in essence, because it makes a rather unrestricted use of classical logic and set theory and, in particular, of the axiom of choice. Recent developments, however, have given rise to the hope that the distance between constructive and nonstandard mathematics is actually much smaller than it appears. So the time was ripe for the first meeting dedicated simultaneously to both ways of doing mathematics and to the current and future reunion of these seeming opposites.

Consisting of peer-reviewed research and survey articles written on the occasion of such an event, this volume offers views of the continuum from various standpoints. Including historical and philosophical issues, the topics of the contributions range from the foundations, the practice, and the applications of constructive and nonstandard mathematics, to the interplay of these areas and the development of a unified theory. This book will be of interest to mathematicians, logicians, and philosophers, as well as theoretical computer scientists, physicists, and economists who are interested in theories of the continuum and in constructive or nonstandard mathematics. The major part is accessible for the non-expert professional reader, from graduate student to academic level. "

This book presents a range of investment appraisal methods and models to help readers make good investment decisions. Each approach is thoroughly described, evaluated, and illustrated using examples, with its assumptions and limitations analyzed in terms of their implications for investment decision-making practice. Getting investment decisions right is crucial but due to a complex and dynamic business environment this remains a challenging management task.

This edited collection bridges the foundations and practice of constructive mathematics and focusses on the contrast between the theoretical developments, which have been most useful for computer science (eg constructive set and type theories), and more specific efforts on constructive analysis, algebra and topology. Aimed at academic logicians, mathematicians, philosophers and computer scientists Including, with contributions from leading researchers, it is up-to-date, highly topical and broad in scope. This is the latest volume in the Oxford Logic Guides, which also includes: 41. J.M. Dunn and G. Hardegree: Algebraic Methods in Philosophical Logic 42. H. Rott: Change, Choice and Inference: A study of belief revision and nonmonotoic reasoning 43. Johnstone: Sketches of an Elephant: A topos theory compendium, volume 1 44. Johnstone: Sketches of an Elephant: A topos theory compendium, volume 2 45. David J. Pym and Eike Ritter: Reductive Logic and Proof Search: Proof theory, semantics and control 46. D.M. Gabbay and L. Maksimova: Interpolation and Definability: Modal and Intuitionistic Logics 47. John L. Bell: Set Theory: Boolean-valued models and independence proofs, third edition

The volume contains a selection of manuscripts of lectures presented at the International Symposi- um on Operations Research (SOR 96). The Symposium took place at the Technical University of Braunschweig, September 3-6, 1996. SOR 96 was organized under the auspices of the two German societies of Operations Research, Deutsche Gesellschaft fur Operations Research (DGOR) and Gesellschaft fur Mathematik, Okonomie and Operations Research (GMOOR) in cooperation with the Working Group Discrete Optimization of the IFIP (WG7.4). Since 1995, DGOR and GMOORjointly prepare the Symposium as a common annual conference. In particular, the annual general meetings of the DGOR, the GMOOR and the WG7.4 took place during the conference. The Symposi~m had 527 participants from 32 countries around the world, including 92 partici- pants from Eastern Europe. The Symposium obviously attracts an international audience of workers fully covering the broad spectrum of Operations Research and related areas in economics, mathema- tics and computer science. The importance of a highly interdisciplinary field as Operations Research is increasing owing to the growth in applications in related disciplines. Technological advances in computer science and algorithmic mathematics are crucial for attacking the great challenges waiting in the areas of applications of Operations Research effectively. As a participant of SOR 96 one could well observe the current pace of achievements. Many of these results are in these proceedings. The program consisted of two plenary, 17 semiplenary, and 335 contributed lectures in 18 sections.

This book originated from a series of papers which were published in "Die Naturwissenschaften" in 1977178. Its division into three parts is the reflection of a logic structure, which may be abstracted in the form of three theses: A. Hypercycles are a principle of natural selforganization allowing an inte gration and coherent evolution of a set of functionally coupled self-rep licative entities. B. Hypercycles are a novel class of nonlinear reaction networks with unique properties, amenable to a unified mathematical treatment. C. Hypercycles are able to originate in the mutant distribution of a single Darwinian quasi-species through stabilization of its diverging mutant genes. Once nucleated hypercycles evolve to higher complexity by a process analogous to gene duplication and specialization. In order to outline the meaning of the first statement we may refer to another principle of material selforganization, namely to Darwin's principle of natural selection. This principle as we see it today represents the only understood means for creating information, be it the blue print for a complex living organism which evolved from less complex ancestral forms, or be it a meaningful sequence of letters the selection of which can be simulated by evolutionary model games."

This textbook presents concepts and applications of Management Accounting, one of the main approaches used by management to support future organisational performance. It covers methods and instruments of management and cost accounting, cost management, and management control and is based on the German textbook "Interne Unternehmensrechnung" by Ralf Ewert and Alfred Wagenhofer (Springer). The authors describe the managerial uses of accounting information, both for decision-making and decision-influencing, and provide a broad perspective on the subject combining the academic foundations of the field with recent cutting-edge research results. Moreover, traditions of German accounting theory and practice that are little known outside of the German-speaking countries are reflected in the book. With its unique approach based on information economics, the textbook offers a comprehensive and innovative presentation to a global audience.

Seven review articles and original papers provide a representative overview of the research work done in hydrogen bond research at Austrian universities. The topics covered by the contributions are: state-of-the-art of understanding hydrogen bonding in biopolymers; recent NMR techniques for studying hydrogen bonding in aqueous solutions; intramolecular hydrogen bonding and proton transfer in a class of Mannich bases derived from substituted phenols and naphthols; competition between intramolecular hydrogen bonds in ortho-disubstituted phenols; molecular dynamic simulations on proton transfer in 5,8-dihydroxynaphthoquinone and in the formic acid dimer; accurate calculations of the intermolecular interactions in cyanoacetylen dimers; correlation between OH...O bond distances and OH stretching frequencies as derived from structural and spectroscopic data of minerals.

Transfer prices are of dominant importance in company practice and a decentralised organisation, e.g. a profit centre-organisation, is most-widely used. This textbook takes an innovative controversial approach by looking at functions of transfer prices and how different types of transfer prices can fulfil them. Suggestions common in other textbooks will be picked up and it will be shown why they do not contribute to solve the problems companies face. With support of numerous examples and exercises a conceptual understanding of this most relevant management topic will be developed. Transfer prices are an issue in most advanced courses on Management Accounting and/or Management Control and their analysis receives increasing attention. They are covered in one chapter in almost all management accounting textbooks. This often leads to serious oversimplifications and reductions of contents. This books aims at filling this gap and to provide a concise and controversial view on the topic.

Die Kostenrechnung liefert Schlusselinformationen fur Entscheider in Unternehmen. Die Autoren zeigen, wie eine solche Rechnung ausgestaltet werden kann. Sie beleuchten die Grundlagen von Vollkosten-, Teilkosten- und Plankostenrechnung und die strategischen Erweiterungen der Rechnung. Durch Zusammenfassungen, Wiederholungsfragen und UEbungsaufgaben mit Loesungen zu jedem Kapitel ist das Buch auch zum Selbststudium geeignet. Es wendet sich an Leser, die sich einen verstandlichen Einstieg in das Gebiet wunschen.

Springers Handbuch der Betriebswirtschaftslehre vermittelt in insgesamt 19 Beitragen einen UEberblick uber die wichtigsten Gebiete der Betriebswirtschaftslehre. Jeder Beitrag liefert eine verstandliche Einfuhrung in die Teilgebiete der Betriebswirtschaftslehre und eine UEbersicht uber aktuelle Entwicklungen. Die Beitrage stellen umfassendes, prufungsrelevantes Wissen fur Wirtschaftswissenschaftler dar. Ziel des Buches ist es, dem Leser betriebswirtschaftliche Fragen, Methoden und Erkenntnisse zu erlautern; es wendet sich in erster Linie an alle, die im Rahmen ihres Studiums betriebswirtschaftliche Zusammenhange erkennen und verstehen wollen sowie an alle, die sich fur ihre praktische Tatigkeit einen UEberblick uber den Stand der Betriebswirtschaftslehre verschaffen wollen. Der (vorliegende) zweite Band erlautert die Kapital- sowie die Informationswirtschaft und schliesst mit Fragen des Innovations- und Umweltmanagements ab.

Das Kompendium bietet Ihnen praxisbezogene Fort- und Weiterbildung in den aktuellen Themen Ihres Fachgebietes. Es fasst ausgewahlte Weiterbildungs-Artikel aus der FacharztZeitschrift "Der Internist" zum Teilgebiet Gastroenterologie in einem kompakten UEberblick fur Sie zusammen. Die "Blauen Seiten" der Weiterbildungsrubrik im "Internist" sind seit langem ein Markenzeichen fur qualifizierte Fort- und Weiterbildung in allen Gebieten der inneren Medizin. Renommierte Autoren, Spezialisten in ihrem Fachgebiet, setzen neueste wissenschaftliche Erkenntnisse in didaktisch ausgefeilte, praxisgerechte Beitrage um. Jetzt sofort griffbereit fur Sie: o wichtige Themen der Gastroenterologie, orientiert an der Weiterbildungsordnung Ihres Fachgebietes, o didaktisch klar und ubersichtlich zum schnellen Nachschlagen und konzentrierten Lernen, o von den Autoren zusatzlich gepruft, uberarbeitet und aktualisiert. Gesichertes Wissen - Ihr Gewinn: Auf Ihrem Weg zum Facharzt und bei Ihren taglichen Fragen in Klinik und Praxis.