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The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG
DEVELOPMENT SERIES explores the critical issues and current topics
in nonclinical drug development. This second volume covers
individual topics and strategies in drug development from compound
characterization to drug registration. Written by a variety of
experts in the field, recent and rapid advances in technologies and
associated changes in regulatory guidance are discussed. Select
topics include: Evolution of Artificial Intelligence (AI)
technologies and the impact on toxicologic pathology. Current
approaches to carcinogenicity testing. Predicting drug-drug
interactions Current understanding of idiosyncratic drug reaction.
Assessing cardiovascular risks beyond QT interval. Use of 3-D cell
cultures in toxicology and ADME. Development of small
molecule-antibody complexes. Differentiating adverse from
non-adverse finding is nonclinical studies. Current Topics in
Nonclinical Drug Development: Volume 2 will aid toxicologists,
toxicologic pathologists, consultants, regulators, Study Directors,
and nonclinical scientists dealing with day-to-day issues
encountered in drug development and assist in formulating
strategies for resolution of these issues. In addition, the book
will be a valuable reference for academicians and graduate students
pursuing research related to nonclinical drug development.
The inaugural volume in the Current Topics in Nonclinical Drug
Development Series explores the critical issues and current topics
in nonclinical drug development. This first volume covers
individual topics and strategies in drug development from compound
characterization to drug registration. Written by a variety of
experts in the field, recent and rapid advances in technologies and
associated changes in regulatory guidance are discussed. Additional
features include: Deals with day-to-day issues in study design,
evaluation of findings, and presentation of data. Explains new
approaches in the development of medical devices. Includes
dedicated chapters on the use of bioinformatics in drug
development. Addresses strategies for photosafety testing of drugs.
Current Topics in Nonclinical Drug Development, Volume I will aid
toxicologists, toxicologic pathologists, consultants, regulators,
Study Directors, and nonclinical scientists dealing with day-to-day
issues in study design, evaluation of findings, and presentation of
data. In addition, the book will be a valuable reference for
academicians and graduate students pursuing research related to
nonclinical drug development.
Following the success of the first edition, this book is designed
to provide practical and timely information for toxicologic
pathologists working in pharmaceutical drug discovery and
development. The majority of the book (Organ Systems) will provide
detailed descriptions of histopathological lesions observed in drug
development. In addition, it will provide information to assist the
pathologist in making determinations of the origin of lesions as
well as its relevance to human risk. Toxicologic Pathology:
Nonclinical Safety Assessment, Second Edition includes 2 new
concept chapters. The first of the new chapters address approaches
for the evaluation of unique therapeutic modalities such as cell
therapies, gene therapies, and gene expression knockdown therapies.
While these still represent new developing therapeutic approaches,
there has been significant experience with the therapeutic
modalities in the last 5 years. The second new chapter addresses
the nonclinical safety assessment of medical devices, a topic of
increasing importance that was not addressed in a unique chapter in
the first edition. The other concept chapters have been updated and
cover important topics including the overview of drug development;
principles of nonclinical safety assessment; an introduction to
toxicologic pathology; techniques used in toxicologic pathology,
clinical pathology, toxicokinetics, and drug development
toxicogenomics; and spontaneous lesions. The 13 organ system
chapters provide the specifics related to pathologic
characteristics, differential diagnosis, and interpretation of
toxic responses in each organ system. These chapters are
specifically important for the bench pathologist but also for the
toxicologist who interacts with pathologists and function as study
toxicologists and project team representatives in the drug
development arena.
There has been a growing interest in toxicologic pathology,
especially as related to its impact on the safety assessment of
pharmaceuticals and chemicals, and in drug development. Thus, there
is a growing need for an Illustrated Dictionary of Toxicology
Pathology and Safety Science (IDTP) that this dictionary aims to
fill. The language of toxicologic pathology may be less familiar to
a broad range of safety scientists, especially those involved in
the safety evaluation of pharmaceuticals and chemicals. The IDTP
format provides the brevity and clarity that the user is not likely
to receive in a textbook, even if adequately indexed. With the
inclusion of descriptions for terms used in toxicology, drug
metabolism/pharmacokinetics, and regulatory science, the scope of
the IDTP is considerably broadened and decidedly unique in its
appeal to all safety scientists. With over 800 photos and
illustrations to provide visual context,* an important aim of the
IDTP is to present pathological changes as reference examples for
terminology, nomenclature, and term descriptions for the entry
entry-level as well as seasoned toxicologic pathologist. It will
also aid students and non-pathology specialists such as study
directors, senior toxicology report reviewers, scientific
management of contract research organizations, regulatory agencies,
and drug development companies to better understand the biological
significance of tissue changes. The IDTP provides a single
reference volume for these users to further their understanding and
appreciation of biologically significant pathology findings. The
IDTP consists of four major areas: 1. A-Z Dictionary of Pathology
encompassing all organ systems, together with relevant
non-pathology terms supported by references in "For Further
Reading" sections. 2. Appendix 1: An Overviews of Drug Development,
Nonclinical Safety & Toxicologic Pathology, and
Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for
Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and
Selected Non-Rodent Laboratory Species containing illustrations
with detailed references and links to source material. 4) Appendix
3: Mini-Atlas of Organ System Anatomy and Histology to help
re-acquaint the non-pathologist safety scientist with many normal
anatomical structures. The editors and contributing scientists
(board-certified veterinary pathologists, board-certified
toxicologists, allied health safety scientists, health regulatory
representatives) have experience from bench-level pathology and
toxicology to managing global preclinical safety units in leading
pharmaceutical companies. They have considerable experience
mentoring pharmaceutical industry project team members, interacting
with industry clinicians and representatives of decision-making
bodies within the industry, as well as with global health
authorities, such as the FDA and EMA. These activities convinced
them of the necessity for and usefulness of the IDTP. As experts in
their field, they have undertaken the hard work of writing and
compiling the information, making the IDTP an exceptional, go-to
reference. *Illustrations Editor: Gregory Argentieri
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