Rick gets pulled back to teenage memories and dreams of 1991 after a horrible car accident. Unable to find his Holly in his true reality his memories and dreams become his reality as he meets his best friend Holly all over again. They were instant friends, and after only the first day together, they cannot stop thinking about each other. As both teens help each other through the teenage worries and fears, they start to face a revelation in their friendship...Love. Reliving his amazing summer with Holly he experiences how they develop an extraordinary relationship between one another that transcends all love and friendship.

Forty years ago, thousands of Milwaukee residents marched for equal rights to join and participate in local organizations, receive equal and appropriate educational resources for their children, and live where they wanted. Thus, the purpose of the book, Asante Sana, 'Thank You' Father James E. Groppi is to commemorate and honor the Father James E. Groppi and the Milwaukee NAACP Youth Council/Commandos who unselfishly put their lives on line and made a significant difference in making Milwaukee's history one that changed the livelihood for all living beings. Specifically, in the book: Asante Sana, 'Thank You' Father James E. Groppi, the author, who was one of the original founders of the Milwaukee NAACP Youth Council in 1964, poetically responds to some of the famous quotes of Father Groppi and the Milwaukee NAACP Youth Council members while they experienced life- threatening issues with racial discrimination in Milwaukee during the 1960's. (Asante Sana, "Thank You" Father James E. Groppi by Dr. Shirley R. (Berry) Butler-Derge (2010).

A vivid and revealing portrait of shipboard life as experienced by eighteenth-century migrants from Europe to the New World In October 1735, James Oglethorpe's Georgia Expedition set sail from London, bound for Georgia. Two hundred and twenty-seven passengers boarded two merchant ships accompanied by a British naval vessel and began a transformative voyage across the Atlantic that would last nearly five months. Chronicling their passage in journals, letters, and other accounts, the migrants described the challenges of physical confinement, the experiences of living closely with people from different regions, religions, and classes, and the multi-faceted character of the ocean itself. Using their specific journey as his narrative arc, Stephen Berry's A Path in the Mighty Waters tells the broader and heretofore underexplored story of how people experienced their crossings to the New World in the eighteenth century. During this time, hundreds of thousands of Europeans-mainly Irish and German-crossed the Atlantic as part of their martial, mercantile, political, or religious calling. Histories of these migrations, however, have often erased the ocean itself, giving priority to activities performed on solid ground. Reframing these histories, Berry shows how the ocean was more than a backdrop for human events; it actively shaped historical experiences by furnishing a dissociative break from normal patterns of life and a formative stage in travelers' processes of collective identification. Shipboard life, serving as a profound conversion experience for travelers both spiritually and culturally, resembled the conditions of a frontier or border zone where the chaos of pure possibility encountered an inner need for stability and continuity, producing permutations on existing beliefs. Drawing on an impressive array of archival collections, Berry's vivid and rich account reveals the crucial role the Atlantic played in history and how it has lingered in American memory as a defining experience.

Thermodynamic Optimization of Finite-Time Processes is the first book to provide a comprehensive treatment integrating finite-time thermodynamics and optimal control, and to give an overview of important breakthroughs in the field which have occurred during the last 20 years. A survey of the optimization technique, including the basics of optimal control theory, and the principal thermodynamic concepts and equations are presented in the first four chapters. The remaining chapters are devoted to the solutions of a variety of finite-time thermodynamic problems, and include coverage of their potential applications for the design of real technological processes, such as:

• heat exchange systems
• mass transfer and separation processes
• commodity exchange as a finite-time thermodynamic process
• heat-driven mechanical processes with one or several reservoirs.

Biotechnology Biotechnology is is now now established established as as a a major major area area of of technology, technology, concerned concerned with with the' the' application application of of biological biological organisms, organisms, systems systems or or processes processes to to manufac turing turing or or service service industries'. industries'. Although Although the the exploitation exploitation of of organisms organisms by by man man is is not not new, new, many many of of the the techniques techniques which which are are stimulating stimulating the the rapid rapid advances advances in in biotechnology biotechnology have have developed developed from from recent recent scientific scientific discoveries. discoveries. Throughout Throughout history history man man has, has, knowingly knowingly or or not, not, been been exploiting exploiting yeast yeast in in the the production production of of alcoholic alcoholic beverages beverages and and bread, bread, and and these these processes processes still still represent represent major major biotechnological biotechnological industries. industries. The The brewer's brewer's and and baker's baker's yeast yeast Sac charomyces charomyces cerevisiae cerevisiae is, is, however, however, also also a a favoured favoured organism organism for for the the production production of of many many new new biotechnological biotechnological products. products."

This monograph develops a unified microscopic basis for phases and phase changes of bulk matter and small systems, based on classical physics. It describes the thermodynamics of ensembles of particles and explains phase transition in gaseous and liquid systems. The origins are derived from simple but physically relevant models of how transitions occur between rigid and fluid states, of how phase equilibria arise, and how they differ for small and large systems.

This volume is the first book to take a deep dive into the philosophical, social, moral, political, and religious issues tackled by Seth MacFarlane's marvelous space adventure, The Orville. Far more than just "Spaceballs for Star Trek," the episodic sci-fi adventure combines humor and philosophy to create a narrative that both engages fans and sheds light on the realities of today's world. These essays explore what The Orville has to say on everything from climate change, artificial intelligence, and sexual assault, to gender, feminism, love, and care. Divided into six "acts" (just like every episode of The Orville), with the show as its backdrop, the book asks questions about the dangers of democracy and social media, the show's relationship to Star Trek and the puzzle of time travel. It features a foreword by The Orville writer and co-executive producer Andre Bormanis.

This book offers the first political theory of special purpose jurisdictions, including 35,000 special districts and 13,500 school districts, which constitute the most common form of local government in the United States today. Collectively, special purpose governments have more civilian employees than the federal government and spend more than all city governments combined. The proliferation of special purpose jurisdictions has fundamentally altered the nature of representation and taxation in local government. Citizens today are commonly represented by dozens - in some cases hundreds - of local officials in multiple layers of government. As a result, political participation in local elections is low and special interest groups associated with each function exert disproportionate influence. With multiple special-interest governments tapping the same tax base, the local tax base takes on the character of a common-pool resource, leading to familiar problems of overexploitation. Strong political parties can often mitigate the common-pool problem by informally coordinating the policies of multiple overlapping governments.

This Second Edition examines the mechanisms and means to establish regulatory compliance for pharmaceutical products and company practices. It focuses on major legislative revisions that impact requirements for drug safety reviews, product regulatory approvals, and marketing practices. Written by top industry professionals, practicing attorneys, and FDA regulators, it includes policies and procedures that pharmaceutical companies need to implement regulatory compliance post-approval. New chapters cover: the marketing of unapproved new drugs and FDA efforts to keep them in regulatory compliance pharmacovigilance programs designed to prevent widespread safety issues legal issues surrounding the sourcing of foreign APIs the issues of counterfeit drugs updates on quality standards

Much has happened in the area of bulk pharmaceutical good manufacturing practice (GMP) and validation since the first publication of Validation of Active Pharmaceutical Ingredients. Revised, updated, and expanded, this second edition includes new chapters addressing postapproval changes, technology transfer, international cGMP guidelines/FDA guidance progress, and facility inspection issues. The basic philosophy and principles of GMP and validation have not changed, but new terminology had been introduced, and old terminology had been better defined, improving the understanding of related concepts and principles. The book gives you a working knowledge of the regulatory process that will facilitate your organization's compliance with regulations.

This book deals with the formulation of the thermodynamics of chemical and other systems far from equilibrium. It contains applications to non-equilibrium stationary states and approaches to such states, systems with multiple stationary states, stability and equi-stability conditions, reaction diffusion systems, transport properties, and electrochemical systems. The theoretical treatment is complemented by experimental results to substantiate the formulation.

This Second Edition examines the mechanisms and means to establish regulatory compliance for pharmaceutical products and company practices. It focuses on major legislative revisions that impact requirements for drug safety reviews, product regulatory approvals, and marketing practices. Written by top industry professionals, practicing attorneys, and FDA regulators, it includes policies and procedures that pharmaceutical companies need to implement regulatory compliance post-approval.

New chapters cover:

• the marketing of unapproved new drugs and FDA efforts to keep them in regulatory compliance
• pharmacovigilance programs designed to prevent widespread safety issues
• legal issues surrounding the sourcing of foreign APIs
• the issues of counterfeit drugs
• updates on quality standards

Biotechnology Biotechnology is is now now established established as as a a major major area area of of technology, technology, concerned concerned with with the' the' application application of of biological biological organisms, organisms, systems systems or or processes processes to to manufac turing turing or or service service industries'. industries'. Although Although the the exploitation exploitation of of organisms organisms by by man man is is not not new, new, many many of of the the techniques techniques which which are are stimulating stimulating the the rapid rapid advances advances in in biotechnology biotechnology have have developed developed from from recent recent scientific scientific discoveries. discoveries. Throughout Throughout history history man man has, has, knowingly knowingly or or not, not, been been exploiting exploiting yeast yeast in in the the production production of of alcoholic alcoholic beverages beverages and and bread, bread, and and these these processes processes still still represent represent major major biotechnological biotechnological industries. industries. The The brewer's brewer's and and baker's baker's yeast yeast Sac charomyces charomyces cerevisiae cerevisiae is, is, however, however, also also a a favoured favoured organism organism for for the the production production of of many many new new biotechnological biotechnological products. products."

This book deals with the formulation of the thermodynamics of chemical and other systems far from equilibrium. It contains applications to non-equilibrium stationary states and approaches to such states, systems with multiple stationary states, stability and equi-stability conditions, reaction diffusion systems, transport properties, and electrochemical systems. The theoretical treatment is complemented by experimental results to substantiate the formulation.

This monograph develops a unified microscopic basis for phases and phase changes of bulk matter and small systems, based on classical physics. It describes the thermodynamics of ensembles of particles and explains phase transition in gaseous and liquid systems. The origins are derived from simple but physically relevant models of how transitions occur between rigid and fluid states, of how phase equilibria arise, and how they differ for small and large systems.

ATLAS OF Small Animal Diagnostic Imaging Comprehensive and up-to-date resource on the interpretation of diagnostic images in small animals using survey radiographs and other modalities Atlas of Small Animal Diagnostic Imaging provides a comprehensive, multimodality atlas of small animal diagnostic imaging, with high-quality images depicting radiography, scintigraphy, ultrasonography, computed tomography, and magnetic resonance imaging. Taking a traditional body systems approach, the book offers an image-intensive resource to survey radiographs with some other imaging modalities being used to emphasize interpretation of survey radiographs. The Atlas offers clinically relevant information for small animal practitioners and students. Each body structure is thoroughly covered and well-illustrated, with discussion of the strengths and weaknesses of each modality in various scenarios. Edited by three experienced radiographers, The Atlas of Small Animal Diagnostic Imaging contains information on: Basics of diagnostic imaging, physics of diagnostic imaging, CT and MRI physics, US physics, and nuclear medicine physics Musculoskeletal normal anatomic variants, developmental orthopedic disease, joint disease, fracture and fracture healing, aggressive bone disease, and head and spine imaging Thorax anatomy, variants, and interpretation paradigm, extrathoracic structures, pleural space, pulmonary parenchyma, and mediastinum Abdomen anatomy, variants, and interpretation paradigm, extra-abdominal and body wall, peritoneal and retroperitoneal, liver and biliary, and spleen With its expansive coverage of the subject and hundreds of high-quality images to aid in efficient and seamless reader comprehension, Atlas of Small Animal Diagnostic Imaging is an invaluable and must-have resource for small animal practitioners, veterinary students, veterinary radiologists, and specialists in a number of areas.

This book offers the first political theory of special purpose jurisdictions, including 35,000 special districts and 13,500 school districts, which constitute the most common form of local government in the United States today. Collectively, special purpose governments have more civilian employees than the federal government and spend more than all city governments combined. The proliferation of special purpose jurisdictions has fundamentally altered the nature of representation and taxation in local government. Citizens today are commonly represented by dozens - in some cases hundreds - of local officials in multiple layers of government. As a result, political participation in local elections is low and special interest groups associated with each function exert disproportionate influence. With multiple special-interest governments tapping the same tax base, the local tax base takes on the character of a common-pool resource, leading to familiar problems of overexploitation. Strong political parties can often mitigate the common-pool problem by informally coordinating the policies of multiple overlapping governments.

A clear and comprehensive framework for bridging the widening gap between theorists and empiricists in social science The credibility revolution, with its emphasis on empirical methods for causal inference, has led to concerns among scholars that the canonical questions about politics and society are being neglected because they are no longer deemed answerable. Theory and Credibility stakes out an opposing view-presenting a new vision of how, working together, the credibility revolution and formal theory can advance social scientific inquiry. This authoritative book covers the conceptual foundations and practicalities of both model building and research design, providing a new framework to link theory and empirics. Drawing on diverse examples from political science, it presents a typology of the rich set of interactions that are possible between theory and empirics. This typology opens up new ways for scholars to make progress on substantive questions, and enables researchers from disparate traditions to gain a deeper appreciation for each other's work and why it matters. Theory and Credibility shows theorists how to create models that are genuinely useful to empirical inquiry, and helps empiricists better understand how to structure their research in ways that speak to theoretically meaningful questions.

A clear and comprehensive framework for bridging the widening gap between theorists and empiricists in social science The credibility revolution, with its emphasis on empirical methods for causal inference, has led to concerns among scholars that the canonical questions about politics and society are being neglected because they are no longer deemed answerable. Theory and Credibility stakes out an opposing view-presenting a new vision of how, working together, the credibility revolution and formal theory can advance social scientific inquiry. This authoritative book covers the conceptual foundations and practicalities of both model building and research design, providing a new framework to link theory and empirics. Drawing on diverse examples from political science, it presents a typology of the rich set of interactions that are possible between theory and empirics. This typology opens up new ways for scholars to make progress on substantive questions, and enables researchers from disparate traditions to gain a deeper appreciation for each other's work and why it matters. Theory and Credibility shows theorists how to create models that are genuinely useful to empirical inquiry, and helps empiricists better understand how to structure their research in ways that speak to theoretically meaningful questions.